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CardioGen automated interpretation system for diagnosis of monogenic cardiovascular diseases

Monogenic cardiovascular disease is a genetic disease in which cardiovascular damage is the only or main phenotype. The total current number of patients worldwide exceeds 10 million.

8 Feb 2023

A novel nomenclature system for pathogens like SARS-CoV-2

Researchers develop an automated method to define pathogen lineages in phylogenetic trees.

8 Feb 2023

The role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute COVID-19

A new clinical outlook in Nature Reviews Cardiology aimed to analyze the post-acute sequelae of COVID-19 that can pose a threat to patients, their doctors, and the healthcare system.

6 Feb 2023

Researchers discover how a protein deficiency can prepare the brain to minimize damage after stress

Astrocytes, small star-shaped cells, play an important role in signal transmission in the brain. Since the protein Ezrin is found abundantly in astrocyte tendrils, it is presumed to play a role in brain function.

3 Feb 2023

Breakthrough technology identifies rare brain tumor cell "spies" disguised as normal cells

Researchers at the Hong Kong University of Science and Technology developed a novel technology which allows genomic DNA and RNA sequencing to be carried out simultaneously in single cells of both frozen and fresh tissues, and identified rare brain tumor cell "spies" disguised as normal cells with this method.

3 Feb 2023

Breakthrough Omicron BA.1/BA.2 infections in the triple-vaccinated linked to broad-based immunity

A new study looked at the whole spectrum of immunological reactions raised by spike and non-spike antigens following Omicron BA.1/BA.2 infections in such individuals, both with and without prior SARS-CoV-2 infection.

1 Feb 2023

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Scientists review existing literature to evaluate the advancements in genomic and exome sequencing for the accurate detection of undiagnosed syndromes.

1 Feb 2023

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times in patients with triple-negative breast cancer (TNBC) that has a "BRCA-like" phenotype.

31 Jan 2023

Migraine diagnosed prior to pregnancy linked to adverse outcomes during pregnancy

Women are disproportionately affected by migraine, especially during their reproductive years. However, the relationship between migraine and adverse pregnancy outcomes has not been well understood.

31 Jan 2023

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

A new study reported a novel form of post-acute coronavirus disease 2019 (COVID-19) syndrome in children.

31 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process.

24 Jan 2023

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

In a recent study published in The Lancet Microbe journal, researchers described the effectiveness of a modular capsid virus-like coronavirus disease 2019 (COVID-19) vaccination.

22 Jan 2023

Senolytics could be a beneficial therapeutic for COVID neuropathology

Researchers assess the effectiveness of multiple senolytic interventions in removing senescent cells in aged human brain organoids.

22 Jan 2023

Study sheds light on the mechanisms behind virulence of MRSA blood stream infections

Researchers at Mount Sinai, in collaboration with researchers at New York University, have published a study in Cell Host and Microbe that sheds light on the mechanisms behind the severity, or virulence, of methicillin-resistant Staphylococcus aureus (MRSA) blood stream infections.

20 Jan 2023

Schizophrenia may be linked with vascular alterations in the brain, study suggests

A study conducted in Brazil and reported in an article published in Molecular Psychiatry suggests that schizophrenia may be associated with alterations in the vascularization of certain brain regions.

19 Jan 2023

Researchers use single-cell RNA-sequencing to study the aging peripheral blood in mice

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, "Single-cell transcriptomics of peripheral blood in the aging mouse."

18 Jan 2023

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Mice exposed to World Trade Center dust exhibit a significant impairment in spatial recognition and short- and long-term memory, as well as changes in genes related to immune-inflammatory responses and blood-brain barrier disruption, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and published January 17 in the Journal of Alzheimer's Disease.

17 Jan 2023

Association between coronary artery calcium dispersion and mortality

Scientists determine whether the estimation of coronary artery calcium dispersion could determine all-cause and causes of specific mortality.

17 Jan 2023

Phenotype News and Research

CardioGen automated interpretation system for diagnosis of monogenic cardiovascular diseases

A novel nomenclature system for pathogens like SARS-CoV-2

The role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute COVID-19

Researchers discover how a protein deficiency can prepare the brain to minimize damage after stress

Breakthrough technology identifies rare brain tumor cell "spies" disguised as normal cells

Breakthrough Omicron BA.1/BA.2 infections in the triple-vaccinated linked to broad-based immunity

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Migraine diagnosed prior to pregnancy linked to adverse outcomes during pregnancy

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Study reveals sex differences in response to drugs targeting tauopathies

Researchers review the association between endogenous retrovirus reactivation and aging

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

Senolytics could be a beneficial therapeutic for COVID neuropathology

Study sheds light on the mechanisms behind virulence of MRSA blood stream infections

Schizophrenia may be linked with vascular alterations in the brain, study suggests

Researchers use single-cell RNA-sequencing to study the aging peripheral blood in mice

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Association between coronary artery calcium dispersion and mortality

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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