Bile News and Research

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GW researcher receives grant to examine link between liver fluke infection and bile duct cancer

Liver fluke infection is a major public health problem affecting more than 10 million people in Southeast Asia, particularly in Thailand and Laos. Infection has been strongly linked to cholangiocarcinoma, or bile duct cancer, an uncommon but aggressive form of cancer.

5 Sep 2018

Bile acids reduce desire for cocaine, finds study

Bile acids -- gut compounds that aid in the digestion of dietary fats -- reduce the desire for cocaine, according to a new study by researchers at Vanderbilt University Medical Center and the University of Alabama at Birmingham.

31 Aug 2018

Newly discovered target may prevent progression of liver injury to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.

27 Aug 2018

Surgeons test new device that keeps the liver warm and circulates blood during transport

Since the first liver transplant in 1963, donated livers have been immersed in an icy cold fluid in a cold storage system for transport, similar in principle to ice chests used for picnics and trips to the beach.

25 Aug 2018

Cardio exercise and strength training have diverse effects on hormones

Every day a lot of people cycle to and from work or visit the gym to lift heavy weights. Regardless of the form of training they choose, almost everyone does it to improve their health. But we actually know surprisingly little about exactly how different forms of training affect our health.

24 Aug 2018

CHLA researchers highlight need to include overweight subjects in metabolic research

Children's Hospital Los Angeles investigators have demonstrated the need to include a growing constituency of obese and overweight children and adults in clinical research, with their study of a key marker for metabolism and body temperature control.

23 Aug 2018

Proof-of-concept technology using nanoparticles could offer new approach for oral medications

Since the development of insulin to manage diabetes, pharmacists have longed to create an insulin pill. Past attempts have failed because insulin does not survive the harsh conditions of the gastro-intestinal system and cannot easily cross the GI wall.

9 Aug 2018

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Nanoparticles show great promise as diagnostic tools and drug delivery agents. The tiny particles, which scientists can modify with drugs, dyes or targeting molecules, can travel in the circulation and squeeze through small spaces into cells and tissues.

9 Aug 2018

Bile acids from the gut may offer new treatment for cocaine abuse

Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by India Reddy, Nicholas Smith, and Robb Flynn of Vanderbilt University, Aurelio Galli of the University of Alabama at Birmingham, and colleagues.

27 Jul 2018

New research reveals how gut bacteria and lipid metabolism may affect AD, other brain diseases

BIOCRATES Life Sciences AG, a global leader in targeted metabolomics, reported today the Alzheimer’s Disease Metabolomics Consortium’s new breakthrough in Alzheimer’s research, which connects the Gut-Liver-Brain axis in the development and progression of Alzheimer’s disease (AD). During the Alzheimer’s Association International Conference, Chicago, USA, researchers reported new data on how gut bacteria and lipid metabolism may influence AD.

26 Jul 2018

Depleting microbiome with antibiotics can have metabolic effects in mice

A new study from the Salk Institute has found that mice that have their microbiomes depleted with antibiotics have decreased levels of glucose in their blood and better insulin sensitivity.

24 Jul 2018

Single genetic change in gut bacteria can lead to obesity

A new study has shown that a single genetic change in a bacterium of the gut microbiome can lead to metabolic diseases such as obesity.

18 Jul 2018

Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice

Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice, according to a study in the journal eLife.

18 Jul 2018

Antidepressant drug appears to effectively stop progression of PBC

Gail Wright considered herself healthy. She had no idea she had a chronic liver disease. "I was at a routine check-up and my doctor said my liver enzymes were elevated. I was sent to a specialist but I wasn't too worried. I didn't have any symptoms."

27 Jun 2018

Clinical trial targets metastatic colorectal cancer with new combination therapy

Rutgers Cancer Institute of New Jersey is offering a clinical trial targeting an advanced form of colorectal cancer with a combination vaccine/immunotherapy drug treatment.

19 Jun 2018

New studies on fat cell filling, history of biochemistry, and ketogenic diet

There's more than one type of fat cell. Besides the white fat that stores triglycerides in lipid droplets in preparation for lean times later, mammals also have heat-generating brown fat, which acts more like a radiator than a storage closet.

14 Jun 2018

Research shows that treating cholestasis in father lowers risk of high blood pressure in son

New research led by Professor Catherine Williamson, School of Life Course Sciences, shows that using drugs to treat male mice with cholestasis reduced the likelihood of male offspring developing high blood pressure.

11 Jun 2018

Lizards with bright green blood baffle scientists

A species of lizards has been found to have bright green blood. Researchers in their study published this Tuesday said that this finding could provide understanding in illnesses such as malaria and jaundice. The study was published in Science Advances.

17 May 2018

TGen scientists develop new quality-control assay to detect cancer from patient's blood sample

Imagine how much patients could benefit if you could discover the presence of cancer, and even how that cancer develops over time, with a simple blood test.

10 May 2018

Walnut consumption impacts gut microbiota and offers many health benefits

Diets rich in nuts, such as walnuts, have been shown to play a role in heart health and in reducing colorectal cancer.

4 May 2018