Genetic News and Research

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Gene silencing and microRNA discovery

One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs.

7 Nov 2005

Tryptophan metabolites play an important role in the immune system

Tryptophan is the source of Thanksgiving legend and grist for a "Seinfeld" episode, but it's not the chemical that you'd expect to find in Lawrence Steinman's lab.

7 Nov 2005

Largest study to date on risk factors associated with primary biliary cirrhosis

A case-control study of more than 2000 people has identified a number of factors that may induce primary biliary cirrhosis (PBC) in genetically susceptible individuals. These include a history of urinary tract infections, hormone replacement therapy, tobacco use, and nail polish use.

3 Nov 2005

Diabetic black men have lower amounts of atherosclerosis than diabetic white men

In a surprising outcome, investigators at Wake Forest University Baptist Medical Center found that diabetic black men have dramatically lower amounts of atherosclerosis, or hardening of the arteries, than diabetic white men.

3 Nov 2005

New findings on bacterial vaginosis

Despite being one of the most common infections among women, scientists and doctors know little about the causes of bacterial vaginosis (BV), a usually benign disease that is also linked to serious health problems including pelvic inflammatory disease

3 Nov 2005

Study examines cancer risks after cancer diagnosis in family

After a person is diagnosed with cancer, increased surveillance among their family members may result in the earlier detection of asymptomatic familial cancers.

3 Nov 2005

Desperate patients cause stem cell web site to crash

The web site of South Korea's new stem cell bank has crashed even before it began taking applications to take part in research.

2 Nov 2005

Protein called CHIP helps untangle protein misfolding in brain disease

Keeping the body and mind healthy depends on keeping cells healthy and functioning. This means that cells need a very robust quality-control system to repair or remove damaged or misshapen proteins. Protein handling is especially important in neurons because damage or death of brain cells causes neurological disease.

1 Nov 2005

Potential new targets for antibiotics

A new study of genetic changes in bacteria may ultimately help drug makers stay a step ahead of disease-causing bacteria that can become resistant to antibiotics.

1 Nov 2005

Breastfeeding does not raise the risk of mother-to-child transmission of hepatitis C virus

One study found that infant girls are twice as likely to be infected as infant boys. Both studies provide new information with which to counsel pregnant women infected with HCV. Taken together, the two new studies expand upon preliminary data from smaller studies of mother-to-child transmission of HCV.

1 Nov 2005

Researchers determine how Tsg101 gene controls cellular growth

Researchers at Emory University School of Medicine and their colleagues have discovered a genetic mechanism that controls cellular growth in the fruit fly Drosophila melanogaster, and believe it likely that a similar system may be at work in normal and cancerous human cells.

1 Nov 2005

Women more at risk for colorectal cancer

A new study of gender and risk factors for colorectal cancer reveals that while both tobacco and alcohol increase risk for colorectal cancer, women who smoke are at higher risk.

1 Nov 2005

Paclitaxel may help treat scleroderma

Using a novel model for scleroderma, researchers from Duke University Medical Center have discovered two important insights into this devastating disorder - the anti-cancer drug paclitaxel (Taxol) may prevent the skin thickening and small blood vessel destruction that characterizes the disease.

1 Nov 2005

INTERACT trial to look at effects of early intensive blood pressure lowering on death and disability in stroke patients

A large clinical trial called INTERACT, launched in China this month, will determine the effects of early intensive blood pressure lowering on death and disability in stroke patients.

1 Nov 2005

At least two "diabetes genes" predict the risk of Type 2 diabete

Scandinavian researchers have confirmed that at least two "diabetes genes" predict the risk of Type 2 diabetes (T2D) when combined with lifestyle factors, in the largest study of its kind to date.

1 Nov 2005

Gene fusion appears to cause prostate cancer

Scientists at the University of Michigan Medical School, in collaboration with researchers at Harvard's Brigham and Women's Hospital, have discovered a recurring pattern of scrambled chromosomes and abnormal gene activity that occurs only in prostate cancer.

30 Oct 2005

DCDC2 gene linked to dyslexia

Pediatric researchers at Yale School of Medicine have identified a gene on human chromosome 6 called DCDC2, which is linked to dyslexia, a reading disability affecting millions of children and adults.

30 Oct 2005

Novel mouse model of medulloblastoma

A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.

30 Oct 2005

Analytical method to trace the lineage trees of cells

Some fundamental outstanding questions in science - "Where do stem cells originate?" "How does cancer develop?" "When do cell types split off from each other in the embryo?" - might be answered if scientists had a way to map the history of the body's cells going back to the fertilized egg.

30 Oct 2005

Gene involved in B-cell development might play a role in multiple sclerosis

The results of a large study published today in the open access journal BMC Neurology reveal that multiple sclerosis (MS) patients are more likely to carry two specific genetic variations in the Early B-cell factor gene (EBF-1), than healthy individuals.

30 Oct 2005