Antibodies News and Research

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Scientists search for cause of mysterious covid-related inflammation in children

Like most other kids with covid, Dante and Michael DeMaino seemed to have no serious symptoms.

20 Oct 2021

Safety and oral immunogenicity of a VSV-derived mucosal vaccine against SARS-CoV-2

A team of researchers exploited the known tropism of vesicular stomatitis virus to develop an oral vaccine that expresses the immunogenic SARS-CoV-2 spike glycoprotein in the oral mucosa.

20 Oct 2021

Long-term predictions of immunity after two doses of mRNA vaccine

Researchers from York University has investigated the long-term protection of two mRNA vaccines.

20 Oct 2021

BNT162b2 mRNA COVID-19 vaccine-induced antibodies wane over six month period

Researchers have been investigating the response of antibodies created against SARS-CoV-2 by the Pfizer-BioNTech six months after vaccination.

20 Oct 2021

Microscopy-based high content platform for SARS-CoV-2 serological screening

A new study published on the medRxiv* preprint server used automated high content immunofluorescence microscopy (AHCIM) to assess the viability of such an approach to detect humoral immune responses against SARS-CoV-2 proteins.

20 Oct 2021

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

A new preprint suggests a fruitful approach to develop such drugs based on biochemical and molecular modeling studies of the drug remdesivir.

19 Oct 2021

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Researchers performed a large-scale, double-blind, placebo-controlled phase two trial to assess the efficacy, safety, and immune response elicited from vaccination with MVC-COV1901.

19 Oct 2021

Structural mechanism of anti-SARS-CoV-2 neutralizing antibodies that target separate spike epitopes

Researchers from the Washington University School Of Medicine have identified how a subset of variants of concern can escape neutralization by two neutralizing antibodies.

19 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

Waning COVID vaccine efficacy especially against reinfection

A new study in American veterans posted to the medRxiv* preprint server suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are less effective in preventing infection after six months. The decline was most significant with the Johnson & Johnson vaccine, with vaccine effectiveness plummeting from 88% to 3%.

19 Oct 2021

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Now, a new medRxiv* preprint study finds mothers vaccinated either one of the messenger RNA (mRNA) vaccines transferred neutralizing antibodies and cytokines, including interferon-gamma (IFNγ), to a breastfeeding child. Additionally, the humoral response in breastmilk was effective in neutralizing four variants of concern.

18 Oct 2021

Many people's T-cells recognize the same components of SARS-CoV-2

A new study published on the bioRxiv* preprint aimed to identify highly immunoprevalent CD8 T-cell epitopes specific to SARS-CoV-2 that are confirmed to be endogenously processed and presented on frequently expressed HLA alleles.

18 Oct 2021

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

A new study discusses risk factors for the failure of seroconversion following full vaccination with the COVID-19 Pfizer vaccine.

18 Oct 2021

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Researchers from Singapore conducted a study to assess the spike protein-specific humoral and cellular immunity in Ad26.COV2.S vaccinated individuals either primed with Ad26.COV2.S only, or boosted with a homologous or heterologous second dose.

18 Oct 2021

Statin treatment and COVID-19 mortality

The authors highlight the importance of their study in clarifying and expanding the current understanding of the relationship between COVID-19 and statins.

18 Oct 2021

New research focuses on better understanding of lupus in Black women

Nine out of 10 patients with systemic lupus erythematosus -; the autoimmune disease also known as SLE -; are females.

18 Oct 2021

Coronavirus vaccines and prior infections can provide broad immunity against similar viruses

Northwestern Medicine scientists have shown for the first time that coronavirus vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics.

18 Oct 2021

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

To address the gaps in the knowledge, a team of researchers from the University of California and the Gladstone Institute of Virology conducted 39-parameter phenotyping by cytometry by time of flight (CyTOF) on 33 longitudinal specimens from 11 mRNA-vaccinated individuals, of which six had previously been infected and recovered from COVID-19.

18 Oct 2021

Research reveals how daily circadian rhythms help to change heart function

A new study has shown how circadian rhythms in heart cells help to change heart function over the course of the day and may explain why shift workers are more vulnerable to heart problems.

18 Oct 2021

Delta and Delta Plus infect lung cells with higher efficiency than the original virus, research shows

The emergence of new SARS-CoV-2 variants that can spread rapidly and undermine vaccine-induced immunity threatens the end of the COVID-19 pandemic. The delta variant (B.1.617.2) emerged in India and subsequently spread globally within a short time period. Also in Germany, almost all recent infections are due to this variant.

18 Oct 2021

Antibodies News and Research

Scientists search for cause of mysterious covid-related inflammation in children

Safety and oral immunogenicity of a VSV-derived mucosal vaccine against SARS-CoV-2

Long-term predictions of immunity after two doses of mRNA vaccine

BNT162b2 mRNA COVID-19 vaccine-induced antibodies wane over six month period

Microscopy-based high content platform for SARS-CoV-2 serological screening

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Structural mechanism of anti-SARS-CoV-2 neutralizing antibodies that target separate spike epitopes

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

Waning COVID vaccine efficacy especially against reinfection

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Many people's T-cells recognize the same components of SARS-CoV-2

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Statin treatment and COVID-19 mortality

New research focuses on better understanding of lupus in Black women

Coronavirus vaccines and prior infections can provide broad immunity against similar viruses

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

Research reveals how daily circadian rhythms help to change heart function

Delta and Delta Plus infect lung cells with higher efficiency than the original virus, research shows

A new way of characterising biomolecules eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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