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Study reveals critical molecular events in the origin of fat cells

A new study reveals critical molecular events in the origin of fat cells. The findings are central to understanding chronic diseases, such as obesity and diabetes, as fat cells produce hormones critical for metabolic control, the researchers said.

21 Sep 2005

First true animal model for psoriasis

Scientists at the Research Institute of Molecular Pathology in Vienna have developed the first true animal model for psoriasis and have been able to address the initial steps and possible causes of the disease.

20 Sep 2005

Adult sickle cell drug hydroxyurea proves effective in young children

A drug used for the treatment of sickle cell anemia in adults has now been shown to cause significant improvements in very young children with the disorder.

20 Sep 2005

New evidence for a genetic pathway that is involved in the recurrence of breast cancer

A study published in the September issue of Cancer Cell provides new evidence for a genetic pathway that is involved in the recurrence of breast cancer and identifies a potential target for development of new anticancer therapeutics.

20 Sep 2005

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Researchers have identified a gene mutation that may increase the risk of prostate cancer up to three times in African-American men with a family history of the disease.

20 Sep 2005

Change in gene may be underlying molecular defect in some colorectal cancers

Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer, according to a new study in the September 21 issue of the Journal of the National Cancer Institute.

20 Sep 2005

O-GlcNAc sugar is a critical regulator of cells' natural life cycle

The discovery reveals that, when disturbed, this process could contribute to cancer or other diseases by failing to properly control the steps and timing of cell division, the researchers say. The findings are described in the Sept. 23 issue of the Journal of Biological Chemistry, available online now.

20 Sep 2005

Low-dose aspirin might prevent the cardiovascular damage known to arise from use of the painkiller rofecoxib (Vioxx)

Their findings that a chemical imbalance might underlie such damage could also lead to the development of anti-inflammatory drugs without the adverse side effects, the researchers said.

20 Sep 2005

85 percent of embryos transferred during in vitro fertilization fail to become live births

Published in the August issue of Fertility and Sterility, the study reviewed seven years of U.S. statistics from all the fertility clinics that report data on reproductive techniques.

20 Sep 2005

Link between CAPON gene and schizophrenia

We have known for a long time that there is a genetic component to schizophrenia, but nailing down the gene(s) has not been easy.

20 Sep 2005

PUMA protein offers critical insights for developing new anti-cancer drugs

The discovery of how the activities of the protein p53 initiate signals that trigger cell suicide offers critical insights for developing new anti-cancer drugs, according to investigators from St. Jude Children's Research Hospital.

20 Sep 2005

Liverpool scientists have found a way of identifying families at high risk of pancreatic cancer

The team has developed a novel means of testing for pancreatic cancer that will enable doctors to treat the killer disease at its earliest stages. They are also now able to show how the risk of cancer for these patients changes with age.

20 Sep 2005

Approximately 25 percent of how a person ages is inherited from parents

According to professor Thomas Kirkwood of the University of Newcastle, there is no single gene for ageing. Throughout time, Humans have used energy to get food, produce offspring and survive danger - not to repair and maintain cells. So the maintenance system in the body slowly breaks down.

19 Sep 2005

Prions rapidly 'remodel' good protein into bad

Two Brown Medical School biologists have figured out the fate of healthy protein when it comes in contact with the infectious prion form in yeast: The protein converts to the prion form, rendering it infectious. In an instant, good protein goes bad.

19 Sep 2005

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Mayo Clinic researchers in collaboration with scientists at Perlegen Sciences, Inc. and funded by the Michael J. Fox Foundation for Parkinson's Research have produced the first large-scale whole genome map of genetic variability associated with Parkinson's disease.

19 Sep 2005

Molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage

Scientists from Maryland and New Jersey have identified a molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage.

19 Sep 2005

First-of-its-kind test on a microchip array will help diagnose retinitis pigmentosa

Rapid genetic testing for eye disease is becoming a reality, thanks to a technology developed at the University of Michigan Kellogg Eye Center.

19 Sep 2005

Study suggests chronic infections may create autoimmune response

New research finds the human immune system has foregone evolutionary changes that would allow it to produce better antibodies in less time because the improved antibodies would be far more likely to attack the body's own tissues.

19 Sep 2005

Less-virulent strain of avian influenza virus can spread from poultry to humans

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online.

19 Sep 2005

Manic depression linked to two chromosomal regions in the human genome

An international team of 53 researchers has offered the most convincing evidence so far linking bipolar disorder, also known as manic depression, to two chromosomal regions in the human genome. The finding gives scientists refined targets for further gene studies.

19 Sep 2005

Genetic News and Research

Study reveals critical molecular events in the origin of fat cells

First true animal model for psoriasis

Adult sickle cell drug hydroxyurea proves effective in young children

New evidence for a genetic pathway that is involved in the recurrence of breast cancer

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Change in gene may be underlying molecular defect in some colorectal cancers

O-GlcNAc sugar is a critical regulator of cells' natural life cycle

Low-dose aspirin might prevent the cardiovascular damage known to arise from use of the painkiller rofecoxib (Vioxx)

85 percent of embryos transferred during in vitro fertilization fail to become live births

Link between CAPON gene and schizophrenia

PUMA protein offers critical insights for developing new anti-cancer drugs

Liverpool scientists have found a way of identifying families at high risk of pancreatic cancer

Approximately 25 percent of how a person ages is inherited from parents

Prions rapidly 'remodel' good protein into bad

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage

First-of-its-kind test on a microchip array will help diagnose retinitis pigmentosa

Study suggests chronic infections may create autoimmune response

Less-virulent strain of avian influenza virus can spread from poultry to humans

Manic depression linked to two chromosomal regions in the human genome

eBook: Using iPSCs models for human disease research and drug discovery eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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