Genetic News and Research

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Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.

19 Jul 2005

Rapid new technique for detecting group A streptococcus

Cornell University scientists have developed a rapid, less costly and sensitive new technique for detecting group A streptococcus, the bacteria that cause scarlet fever. Details will be announced today at the Institute of Food Technologists Annual Meeting and Food Expo in New Orleans.

18 Jul 2005

Variations in the gene for protein kinase C beta 1 (PRKCB1) strongly associated with autism

This exciting finding suggests some answers to a number of previous, but unexplained, observations about autism and provides the potential for a mechanistic explanation for some of the characteristics of the condition. The results of the study are published today in the journal Molecular Psychiatry.

18 Jul 2005

Scientists have identified a gene associated with both childhood and adult obesity

According to research published today in Nature Genetics, the team from Imperial College London, Hammersmith Hospital, London, and the CNRS Lille, France, have identified a gene (ENPP1), with strong links to childhood obesity in 3,147 in a sample of 4,886 French Caucasian individuals.

18 Jul 2005

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

In direct contrast to previous reports, researchers now say that drinking gallons of orange juice and popping vitamin pills may not be a guarantee that you will live longer.

18 Jul 2005

Chemical sealant - poloxamer 188 can repair damage to cardiac muscle cell membrane

A common chemical used in the manufacturing and pharmaceutical industries can repair damage to cardiac muscle cell membranes and prevent heart failure in mice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientists at the University of Michigan Medical School.

18 Jul 2005

Genome studies may help target new drugs to fight them

One parasite causes a deadly sleeping sickness in Africa. The second damages the internal organs of millions of Latin Americans. The third causes terrible lesions on the face or limbs of victims from Brazil to India.

18 Jul 2005

Study shows mutation in NOTCH1 gene causes aortic valve disease

By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a common heart birth defect as well as a major contributor to adult heart disease.

18 Jul 2005

New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

RNA dynamics may help in drug design

Biophysicists have developed a method for studying, in real time, a nanoscale "docking and undocking" interaction between small pieces of ribonucleic acid (RNA), a technique that may be broadly useful in studying structural changes in RNA that affect its function.

17 Jul 2005

Extraordinary number of genes are required for prenatal mammalian development

A team of scientists led by Cornell University's Dr. John Schimenti reports today that an extraordinary number of genes are required for prenatal mammalian development. The researchers estimate that up to 19% of all genes are vital for embryogenesis in mice.

17 Jul 2005

Individuals with inactive heterozygous ALDH2, a tendency to alcohol flushing have a greater susceptibility to hangovers

Alcohol consumption is an integral part of the Japanese business culture. Hangovers, however, can have substantial economic drawbacks.

17 Jul 2005

Data directly support a pathogenetic model of acute leukemia

Acute myeloid leukemia (AML) is frequently caused by genetic alterations that affect transcription factors, such as AML1-ETO and mutations affecting genes involved in signal transduction pathways, such as FLT3.

15 Jul 2005

Having asthma, hay fever or another allergic condition may reduce the risk of developing Glioblastoma multiforme

Glioblastoma multiforme (GBM) affects three out of 100,000 people, a rate that quadruples to 13 out 100,000 among people who are 65 and older. The average five-year survival rate from the time of diagnosis for GBM is only 3.3 percent, and is lower for people 65 and older.

15 Jul 2005

Shared-environmental influences on gender-role behaviour may be more important in early childhood than in adolescence and adulthood

Whether little boys prefer to play with trucks or dolls depends more on the family environment than genetics, while genetics seems to play a larger role in little girls' preferences for dolls over trucks, according to a study published in the July/August 2005 issue of the journal Child Development.

14 Jul 2005

Canadian researchers look at origins of social aggression

Anyone who has watched a clique of third-grade girls overtly ignore another little girl understands the hurt this type of aggression - called social aggression - can inflict upon others.

14 Jul 2005

New search method could aid in the discovery of biomarkers for breast cancer

Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.

13 Jul 2005

White blood cell called a neutrophil appears to be crucial to abdominal aortic aneurysm formation

Each year, 200,000 Americans find out that the largest blood vessel in their body, the aorta, may burst open at any time. About 20,000 die suddenly from such a rupture. And another 36,000 have surgery to repair or replace the swelling section of aorta before time runs out.

13 Jul 2005

New method may accelerate the way cancer-causing genes are found

Researchers at the University of Minnesota Cancer Center and the National Cancer Institute (NCI) have discovered a new method that could accelerate the way cancer-causing genes are found and could lead to a more accurate identification of the genes, according to two studies in the July 14, 2005, issue of Nature.

13 Jul 2005

Researchers identify six genes associated with lymphocytic bronchitis - could mean new test, treatments

Researchers at the San Francisco VA Medical Center (SFVAMC) and the University of California, San Francisco (UCSF) have identified six genes associated with lymphocytic bronchitis, which is thought to lead to obliterative bronchitis (OB), the most common cause of long-term failure of transplanted lungs.

13 Jul 2005

Genetic News and Research

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Rapid new technique for detecting group A streptococcus

Variations in the gene for protein kinase C beta 1 (PRKCB1) strongly associated with autism

Scientists have identified a gene associated with both childhood and adult obesity

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

Chemical sealant - poloxamer 188 can repair damage to cardiac muscle cell membrane

Genome studies may help target new drugs to fight them

Study shows mutation in NOTCH1 gene causes aortic valve disease

New molecular insights may one day lead to opportunities to stave off old age

RNA dynamics may help in drug design

Extraordinary number of genes are required for prenatal mammalian development

Individuals with inactive heterozygous ALDH2, a tendency to alcohol flushing have a greater susceptibility to hangovers

Data directly support a pathogenetic model of acute leukemia

Having asthma, hay fever or another allergic condition may reduce the risk of developing Glioblastoma multiforme

Shared-environmental influences on gender-role behaviour may be more important in early childhood than in adolescence and adulthood

Canadian researchers look at origins of social aggression

New search method could aid in the discovery of biomarkers for breast cancer

White blood cell called a neutrophil appears to be crucial to abdominal aortic aneurysm formation

New method may accelerate the way cancer-causing genes are found

Researchers identify six genes associated with lymphocytic bronchitis - could mean new test, treatments

eBook: Using iPSCs models for human disease research and drug discovery eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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