Brain Metastases News and Research

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Research paves way for clinical trials of existing drugs for brain metastasis

The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialled to find out if they could treat the disease.

29 Nov 2023

Study uncovers cell signaling pathway that regulates melanoma brain metastasis

Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body.

29 Nov 2023

World's first living brain metastasis biobank paves way for personalized cancer treatment

At 18 Spanish hospitals, when a patient with brain metastasis undergoes surgery, they can donate a tiny part of their brain to the first repository of brain metastasis living samples in the world, based at CNIO (Spanish National Cancer Research Centre).

31 Oct 2023

New treatment options offer hope for patients with non-small cell lung cancer

More people with non-small cell lung cancer (NSCLC) are likely to benefit from new drugs that target molecular alterations in tumour cells, with less need for chemotherapy, following results of multiple landmark clinical trials reported for the first time in late-breaking presentations at the ESMO Congress 2023 (1-7).

17 Oct 2023

Study details the key role played by neutrophils in ensuring survival of brain cancers

A Ludwig Cancer Research study has for the first time exhaustively analyzed immune cells known as neutrophils that reside in brain tumors, including gliomas, which develop in the brain itself, and cancers that spread there from the lung, breast and skin.

27 Sep 2023

New research could help improve the effectiveness of immunotherapy for people with brain tumors

A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds new light on why tumors that have spread to the brain from other parts of the body respond to immunotherapy while glioblastoma, an aggressive cancer that originates in the brain, does not.

1 Sep 2023

New precision medicine trial shows promise for treating rare brain tumors

Papillary craniopharyngiomas (PCPs) are a rare type of brain tumor that cause substantial morbidity for patients.

13 Jul 2023

Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

24 Jun 2023

Adagrasib shows promise for the treatment of patients with KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center found the KRAS G12C inhibitor adagrasib showed promising activity suppressing cancer growth not only within the lungs but also in brain metastases for patients with KRAS G12C-mutated non-small cell lung cancer.

16 Jun 2023

Preoperative stereotactic radiosurgery improves outcomes for patients with metastatic brain tumor

Cancer that spreads to the brain from another part of the body such as lung or breast is called a metastatic brain tumor.

8 Jun 2023

Researchers discover mechanisms behind aggressive cancer metastases

Breast cancer spreading to other organs usually heralds a poorer prognosis. Researchers at the University and University Hospital of Basel have discovered a process that helps breast cancer cells implant themselves in certain places in the body.

6 Jun 2023

Study of immunotherapy for brain cancer metastases shows promising results

In a phase 2 clinical trial of the immune checkpoint inhibitor pembrolizumab, investigators found that 42 percent of patients with metastatic brain cancer benefited from the therapy, with seven patients in the trial surviving longer than two years.

2 Jun 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

ASTRO/ESTRO's clinical guideline offers recommendations on the use of local therapy for oligometastatic NSCLC

A new clinical guideline from the American Society for Radiation Oncology and European Society for Radiotherapy & Oncology provides guidance on the use of definitive local therapy-; including radiation and surgery-; to treat patients with oligometastatic non-small cell lung cancer (NSCLC).

25 Apr 2023

New way to carry drugs across the blood-brain barrier using nanoparticles

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

New cooling strategy could prevent the growth of glioblastoma

Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident.

12 Jan 2023

Study uncovers molecular features responsible for the development, progression of metastatic breast cancer

A multi-institutional national study has identified unique molecular features responsible for the development and progression of metastatic breast cancer.

9 Jan 2023

T-DXd leads to longer overall survival in HER2-positive metastatic breast cancer patients than T-DM1

Second-line treatment with trastuzumab deruxtecan (T-DXd) led to significantly longer overall survival compared with trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer, according to updated results from the DESTINY-Breast03 phase III clinical trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Blood tests may be able to guide treatment discussions for patients with metastatic cancer

As cancers grow and potentially spread to new parts of the body, they often shed cells and DNA into the blood stream. DNA can be analyzed for both the amount of DNA present and whether any potential mutations exist that may aid providers in deciding on treatments.

29 Nov 2022

Study develops a strategy to noninvasively track tumor-associated macrophages

A Ludwig Cancer Research study has developed a strategy to noninvasively track immune cells known as macrophages within brain and breast tumors in living mice.

19 Oct 2022