Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Study: Children with type 1 diabetes five times more likely to be admitted to hospital

Children living with type 1 diabetes are nearly five times more likely to be admitted to hospital than non-diabetic children, a new study (attached) has found.

15 Apr 2015

Children with type 1 diabetes five times more likely to be admitted to hospital

The number of children being diagnosed with type 1 diabetes is increasing 3-4% every year and more so in school-aged children. Treating the condition is complex and poor management can often lead to medical emergencies that result in hospitalisation, placing ever greater demands on health services

14 Apr 2015

Aeterna Zentaris plans to conduct Macrilen Phase 3 clinical study for AGHD

Aeterna Zentaris Inc. today announced plans to conduct a new, confirmatory Phase 3 clinical study to demonstrate the efficacy of Macrilen (macimorelin), a novel orally-active ghrelin agonist for use in evaluating adult growth hormone deficiency ("AGHD"), as well as a dedicated thorough QT study to evaluate the effect of Macrilen on myocardial repolarization.

13 Apr 2015

Better insulin injection technique can improve blood glucose control in diabetes patients, says study

A recent study by Grassi et al. has concluded that blood glucose control in diabetes patients who inject insulin can be improved through better injection technique, which includes switching patients to 4 mm pen needles.

10 Apr 2015

AstraZeneca selects Regulus' RG-125 as clinical candidate for treatment of NASH

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today the selection of RG-125 (AZD4076), a GalNAc-conjugated anti-miR targeting microRNA-103/107 (“miR-103/107”) for the treatment of Non Alcoholic Steatohepatitis (“NASH) in patients with type 2 diabetes/pre-diabetes, as a clinical candidate by AstraZeneca under the companies’ strategic alliance to discover, develop and commercialize microRNA therapeutics.

9 Apr 2015

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

A cellular defect that can impair the body's ability to handle high glucose levels and could point the way to a potential new treatment for diabetes has been identified by Columbia University Medical Center researchers.

8 Apr 2015

Study identifies gut immune system as new, effective target for diabetes

A commonly-used drug to treat inflammatory bowel disease, such as Crohn's disease, has been shown to lower blood sugar levels in obese mice, potentially identifying the gut immune system as a new and effective target in treating diabetes in humans.

8 Apr 2015

DreaMed Diabetes and Medtronic enter strategic collaboration

DreaMed Diabetes, developer of diabetes treatment and management solutions, announced today that it had signed an exclusive worldwide development and license agreement with Medtronic, the world's premier medical technology and services company, for the development and marketing of products incorporating DreaMed’s MD-Logic Artificial Pancreas algorithm in Medtronic’s insulin pumps.

From Medtronic 7 Apr 2015

Researchers discover genetic factors key to POMC cells

The little voice inside your head that tells you to eat, or stop eating, isn't a little voice - it's actually a cluster of about 10,000 specialized brain cells. And now, an international team of scientists has found tiny triggers inside those cells that give rise to this "voice", and keep it speaking throughout life.

6 Apr 2015

Combined therapy boosts growth in short children with low IGF-1

Children with short stature benefit from receiving combined treatment with growth hormone and insulin-like growth factor-1, if they have low endogenous levels of the latter, a study shows.

1 Apr 2015

Prolonged insulin therapy often unnecessary in children with Type 2 diabetes

Many children who require insulin treatment on diagnosis with Type 2 diabetes can be weaned off the medication, show findings from the run-in phase of the Treatment Options for Type 2 Diabetes in Adolescents and Youth study.

1 Apr 2015

FGF21 protein can boost regenerative effects of human PPARα

Researchers at UC Davis have illuminated an important distinction between mice and humans: how human livers heal. The difference centers on a protein called PPARα, which activates liver regeneration. Normally, mouse PPARα is far more active and efficient than the human form, allowing mice to quickly regenerate damaged livers.

1 Apr 2015

Study: Adding peanuts to a high fat meal improves vascular function

A study of peanut consumption showed that including them as a part of a high fat meal improved the post-meal triglyceride response and preserved endothelial function.

31 Mar 2015

Reoccurring oxygen deprivation during pregnancy affects offspring's liver function

Sleep apnea, a disorder in which breathing repeatedly stops during sleep, is a potentially serious condition because it deprives the body of oxygen. It becomes an even more serious condition in pregnant women—who can be more prone to it—because the oxygen deprivation may affect the baby.

30 Mar 2015

AACR to honor Lewis C. Cantley with Princess Takamatsu Memorial Lectureship

The American Association for Cancer Research will honor Lewis C. Cantley, PhD, with the ninth annual Princess Takamatsu Memorial Lectureship at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

29 Mar 2015

Anti-diabetic medication activates brain sensors, promotes weight gain

Medication used to treat patients with type II diabetes activates sensors on brain cells that increase hunger, causing people taking this drug to gain more body fat, according to researchers at Georgia State University, Oregon Health and Science University, Georgia Regents University and Charlie Norwood Veterans Administration Medical Center.

27 Mar 2015

Research reveals why people with type 1 diabetes are unable to control blood glucose levels

TEACHING people with type 1 diabetes how to embed lifelong habits such as carbohydrate counting into everyday life rather than as part of week-long education programmes could significantly reduce their risk of complications from the disease, according to new research.

27 Mar 2015

GFT505 demonstrates dose-dependent efficacy on primary endpoint in phase 2 NASH trial

GENFIT, today announces topline results of the phase 2 GOLDEN-505 trial in NASH. Due to the unexpected rate of resolution of NASH in patients randomized to placebo who had early NASH (NAS of 3, placebo response rate>57%), along with the high number of sites for a limited sample size, the study as initially designed did not enable the trial to meet directly the primary endpoint.

27 Mar 2015

AstraZeneca, HSCI collaborate to find new treatments for diabetes

AstraZeneca today announced that it has entered into a five-year research collaboration with the Harvard Stem Cell Institute to adapt a technique that creates human beta cells from stem cells for use in screens of AstraZeneca’s compound library in the search for new treatments for diabetes.

26 Mar 2015

Study finds clustered cardiometabolic risk factors in children

Lifestyle-related cardiometabolic risk factors cluster already in children in the same way as in adults, according to research from the University of Eastern Finland. A cardiometabolic risk score was used to evaluate cardiometabolic risk in different age groups.

25 Mar 2015

Insulin News and Research

Further Reading

Study: Children with type 1 diabetes five times more likely to be admitted to hospital

Children with type 1 diabetes five times more likely to be admitted to hospital

Aeterna Zentaris plans to conduct Macrilen Phase 3 clinical study for AGHD

Better insulin injection technique can improve blood glucose control in diabetes patients, says study

AstraZeneca selects Regulus' RG-125 as clinical candidate for treatment of NASH

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

Study identifies gut immune system as new, effective target for diabetes

DreaMed Diabetes and Medtronic enter strategic collaboration

Researchers discover genetic factors key to POMC cells

Combined therapy boosts growth in short children with low IGF-1

Prolonged insulin therapy often unnecessary in children with Type 2 diabetes

FGF21 protein can boost regenerative effects of human PPARα

Study: Adding peanuts to a high fat meal improves vascular function

Reoccurring oxygen deprivation during pregnancy affects offspring's liver function

AACR to honor Lewis C. Cantley with Princess Takamatsu Memorial Lectureship

Anti-diabetic medication activates brain sensors, promotes weight gain

Research reveals why people with type 1 diabetes are unable to control blood glucose levels

GFT505 demonstrates dose-dependent efficacy on primary endpoint in phase 2 NASH trial

AstraZeneca, HSCI collaborate to find new treatments for diabetes

Study finds clustered cardiometabolic risk factors in children

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