Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

COVID-19 patients discharged from hospital have increased rates of multiorgan dysfunction

People discharged from hospital after covid-19 appear to have increased rates of organ damage (“multiorgan dysfunction”) compared with similar individuals in the general population, finds a study published by The BMJ today.

1 Apr 2021

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

Drinking flavanol-rich cocoa could protect from mental stress-induced cardiovascular events

Increased consumption of flavanols - a group of molecules occurring naturally in fruit and vegetables - could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research.

31 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein

Researchers from Israel describe a novel SARS-CoV-2 strain with a non-synonymous mutation in its spike glycoprotein, designated as P681H; nevertheless, its emergence has not been associated with increased infections rate, facilitated spread or vaccine evasion.

30 Mar 2021

Study: Patients with chronic kidney disease have high risk of acute kidney injury

Acute kidney injury (AKI) occurred in nearly 20 percent of patients who underwent surgery with implantation of antibiotic-loaded "spacers" and intravenous (IV) antibiotics for the treatment of deep infections after total knee arthroplasty, reports a study in The Journal of Bone & Joint Surgery.

30 Mar 2021

Low-cost hypertension management intervention can be cost-effectively scaled up in rural South Asia

A low-cost intervention to improve hypertension--or high blood pressure (BP)--prevention and management can be cost-effectively scaled up for rural communities in low- and middle-income countries, according to findings from a multi-country trial published in The Lancet Global Health.

29 Mar 2021

Study shows safety, efficacy of percutaneous thermal ablation for treating metastatic gynecologic cancers

A new study by researchers at the UCLA Jonsson Comprehensive Cancer Center found using percutaneous image guided needle based thermal ablation -- the precise application of extreme heat or cold to a tumor using sophisticated ultrasound, CT or MRI in a single outpatient session -- is a safe and effective adjunctive therapy for the local control of metastatic gynecologic cancers throughout lungs, liver, soft tissues in the abdomen and pelvis and bones in patients with advanced localized cancers unresponsive to systemic therapy.

29 Mar 2021

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

A team of researchers led by UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital (GOSH) has found that metformin - a drug commonly used to treat Type 2 diabetes - can successfully reduce symptoms associated with tuberous sclerosis complex (TSC), including reduction in the frequency of seizures and the size of brain tumors.

29 Mar 2021

Combined clinical and genomic data better predicts COVID-19 severity

The current COVID-19 outbreak is one of the worst pandemics in history and has claimed millions of lives across the globe, overwhelmed healthcare systems, and created unprecedented socio-economic ramifications.

28 Mar 2021

Selecting SARS-CoV-2 inhibitors in human airway epithelial cells

In a recent article currently available on the bioRxiv* preprint server, researchers from Belgium and the U.S. demonstrated a robust replication model for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolates in primary human epithelial cells at the air-liquid interface and appraised the antiviral effect of selected viral replication inhibitors.

28 Mar 2021

Demographic and clinical comparison of the first and second COVID-19 waves in London, UK

In a paper recently uploaded to the preprint server medRxiv*, clinical and demographic data from across the UK is compared to viral genome sequence data, identifying trends amongst the population affected, and across SARS-CoV-2 strains.

26 Mar 2021

The pressure is on to diagnose and treat chronic kidney disease

In this interview, Helen Yeh, the Vice President, Biopharmaceuticals Medical, Cardiovascular, Renal and Metablosim at AstraZeneca , talks News-Medical to about chronic kidney diseas (CKD).

From AstraZeneca 26 Mar 2021

New study may shed light on inflammatory bowel disease

Researchers have found an unexpected synergy between a T-cell stimulatory protein -- the ICOS ligand -- and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

26 Mar 2021

Researchers reveal a mechanistic link in kidney cancer between fat metabolism and obesity

Altered cellular energetics, a hallmark of cancers, has been associated with obesity. However, links between systemic energy regulation and aberrant cancer cell metabolism have been lacking.

25 Mar 2021

Study examines the health effects of diet and resistance training in middle-aged adults

A 10-week muscle-building and dietary program involving 50 middle-aged adults found no evidence that eating a high-protein diet increased strength or muscle mass more than consuming a moderate amount of protein while training.

25 Mar 2021

ColoradoSPH wins NIH grant to study how air pollutants impact kidney health of sugarcane workers

Three groups from the Colorado School of Public Health have been awarded a $3 million 5-year grant from the National Institutes of Health to study the effects of air pollution and climate on the kidney health of sugarcane workers in Guatemala.

25 Mar 2021

Fluoxetine (Prozac) performs strongly in vitro against SARS-CoV-2 (including mutants)

Researchers from Finland, to expand on these studies, tested some of these drugs against the new SARS-CoV-2 variants. The study is published on the preprint server bioRxiv.

24 Mar 2021

Increased replicative fitness of SARS-CoV-2 UK strain in human bronchial cells

A recent study from France showed that the UK variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – also known as B.1.1.7 variant – can replicate much more efficiently in a reconstituted human bronchial epithelium, which may explain why it spreads so rapidly in the human population. The study is currently freely available on the bioRxiv preprint server.

24 Mar 2021

Dandelion extract inhibits SARS-CoV-2 in vitro

An exciting new study describes a specific inhibitor of the SARS-CoV-2 found in an extract of the common dandelion that could provide a new and fruitful avenue of drug research.

23 Mar 2021

Nephrology News and Research

Further Reading

COVID-19 patients discharged from hospital have increased rates of multiorgan dysfunction

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

Drinking flavanol-rich cocoa could protect from mental stress-induced cardiovascular events

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein

Study: Patients with chronic kidney disease have high risk of acute kidney injury

Low-cost hypertension management intervention can be cost-effectively scaled up in rural South Asia

Study shows safety, efficacy of percutaneous thermal ablation for treating metastatic gynecologic cancers

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

Combined clinical and genomic data better predicts COVID-19 severity

Selecting SARS-CoV-2 inhibitors in human airway epithelial cells

Demographic and clinical comparison of the first and second COVID-19 waves in London, UK

The pressure is on to diagnose and treat chronic kidney disease

New study may shed light on inflammatory bowel disease

Researchers reveal a mechanistic link in kidney cancer between fat metabolism and obesity

Study examines the health effects of diet and resistance training in middle-aged adults

ColoradoSPH wins NIH grant to study how air pollutants impact kidney health of sugarcane workers

Fluoxetine (Prozac) performs strongly in vitro against SARS-CoV-2 (including mutants)

Increased replicative fitness of SARS-CoV-2 UK strain in human bronchial cells

Dandelion extract inhibits SARS-CoV-2 in vitro

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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