Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Chromosome X microduplications implicated in infancy-onset gigantism

Researchers report that heritable microduplications on chromosome Xq26.3 may underlie a “striking” form of gigantism with onset in late infancy, and reveal a candidate culprit gene.

22 Dec 2014

Two hormones better than one for hypoglycaemia prevention with artificial pancreas

Artificial pancreas systems significantly improve glycaemic control in adolescents and adults with Type 1 diabetes, shows a head-to-head trial of single- and dual-hormone systems versus a conventional insulin pump.

22 Dec 2014

Novo Nordisk gets positive CHMP opinion for expanded use of Tresiba in children with diabetes

Novo Nordisk today announced that the Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion for expanded use of Tresiba® (insulin degludec) in children and adolescents aged one to 17 years with diabetes.

From Novo Nordisk 22 Dec 2014

Lilly, Adocia team up to develop BioChaperone Lispro insulin for treatment of diabetes

Eli Lilly and Company and Adocia today announced a worldwide licensing collaboration focused on developing an ultra-rapid insulin, known as BioChaperone Lispro, for treatment in people with type 1 and type 2 diabetes.

19 Dec 2014

Findings show effective treatment for type 1 diabetes patients with severe hypoglycemia

Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.

18 Dec 2014

Eating bilberries reduces adverse effects of high-fat diets

Eating bilberries diminishes the adverse effects of a high-fat diet, according to a recent study at the University of Eastern Finland. For the first time, bilberries were shown to have beneficial effects on both blood pressure and nutrition-derived inflammatory responses.

18 Dec 2014

Researchers examine why Mexican-Americans at increased risk for Type 2 diabetes

While people of Mexican ancestry are nearly twice as likely to develop Type 2 diabetes as people of European heritage, the majority of research in this area has focused on those of European origin.

18 Dec 2014

Study: Low glycemic diet does not improve insulin sensitivity or cardiovascular risk factors

Nutrition experts are continually debating the nutritional value of carbohydrate-containing foods and whether some are healthier than others. High carbohydrate foods are classified by how much they increase blood sugar; known as glycemic index. In new findings led by researchers at Brigham and Women's Hospital in Boston and Johns Hopkins University in Baltimore, researchers looked at glycemic index' effect on cardiovascular disease (CVD) and diabetes and found that low glycemic diets did not improve insulin sensitivity or cardiovascular risk factors.

16 Dec 2014

Ortho-Clinical Diagnostics announces availability of NEPHROCHECK Test System for AKI patients

Ortho-Clinical Diagnostics, Inc. today announced the nationwide availability to hospitals of the NEPHROCHECK Test System designed to help healthcare providers identify patients at risk of developing moderate or severe acute kidney injury (AKI) within 12 hours of patient assessment.

From Ortho-Clinical Diagnostics, Inc. 16 Dec 2014

Joslin study could lead to improved anti-aging drugs

In a study published today by Nature, researchers at Joslin Diabetes Center used a microscopic worm (C. elegans) to identify a new path that could lead to drugs to slow aging and the chronic diseases that often accompany it--and might even lead to better cosmetics.

16 Dec 2014

Study provides evidence for presence of enterovirus in pancreatic islets of type 1 diabetic patients

Norwegian scientists with European partners have found evidence for the presence of Enterovirus in pancreatic islets of type 1 diabetic patients. This provides evidence consistent with the theory that a low grade Enteroviral infection in the pancreatic islets contribute to disease progression in humans.

16 Dec 2014

Novartis announces FDA approval of Signifor LAR for treatment of patients with acromegaly

Novartis announced today that the US Food and Drug Administration has approved Signifor long-acting release (LAR) (pasireotide) for injectable suspension, for intramuscular use, for the treatment of patients with acromegaly who have had an inadequate response to surgery and/or for whom surgery is not an option.

16 Dec 2014

Children who skip meals more likely to have excess body fat, increased cardiometabolic risk

Children who skip main meals are more likely to have excess body fat and an increased cardiometabolic risk already at the age of 6 to 8 years, according to a Finnish study. A higher consumption of sugary drinks, red meat and low-fat margarine and a lower consumption of vegetable oil are also related to a higher cardiometabolic risk.

15 Dec 2014

New study finds that immune cells in the brain may contribute to obesity

Immune cells perform a previously unsuspected role in the brain that may contribute to obesity, according to a new study by UC San Francisco researchers.

14 Dec 2014

Figitumumab development discontinued for non-adenocarcinoma NSCLC

Adding the novel insulin-like growth factor 1 receptor inhibitor figitumumab to the epidermal growth factor receptor–tyrosine kinase inhibitor erlotinib does not improve survival in patients with non-adenocarcinoma non-small-cell lung carcinoma, research shows.

12 Dec 2014

UR researchers on track to solve mystery of weight gain

University of Rochester researchers believe they're on track to solve the mystery of weight gain - and it has nothing to do with indulging in holiday eggnog.

12 Dec 2014

Study finds link between hypoglycaemia and increased risk of cardiovascular events

A study involving scientists from the University of Leicester has established a link between hypoglycaemia and increased risk of cardiovascular events and mortality in patients with diabetes.

12 Dec 2014

UB study creates new awareness for diabetics who are at risk for dehydration

Some drugs used to treat diabetes mimic the behavior of a hormone that a University at Buffalo psychologist has learned controls fluid intake in subjects. The finding creates new awareness for diabetics who, by the nature of their disease, are already at risk for dehydration.

12 Dec 2014

New interoperability standards for diabetes devices

JDRF and the Centre for Global eHealth Innovation at the University Health Network in Toronto announced publication of interoperability standards for diabetes devices. The work is the result of JDRF Canadian Clinical Trial Network funding to Dr. Joseph Cafazzo at UHN to pilot the development of standard communication protocols that define how diabetes devices, such as insulin pumps, blood glucose meters, and continuous glucose monitors, communicate with one another and with other devices.

12 Dec 2014

FDA clears ArmaGen's AGT-182 IND application for treatment of Hunter syndrome

ArmaGen, Inc., a privately held biotechnology company focused on developing novel therapies to treat severe neurological disorders, announced today that the Investigational New Drug (IND) application for the company's lead product candidate, AGT-182 for the treatment of Hunter syndrome, has been accepted by the U.S. Food and Drug Administration and is now active.

11 Dec 2014

Insulin News and Research

Further Reading

Chromosome X microduplications implicated in infancy-onset gigantism

Two hormones better than one for hypoglycaemia prevention with artificial pancreas

Novo Nordisk gets positive CHMP opinion for expanded use of Tresiba in children with diabetes

Lilly, Adocia team up to develop BioChaperone Lispro insulin for treatment of diabetes

Findings show effective treatment for type 1 diabetes patients with severe hypoglycemia

Eating bilberries reduces adverse effects of high-fat diets

Researchers examine why Mexican-Americans at increased risk for Type 2 diabetes

Study: Low glycemic diet does not improve insulin sensitivity or cardiovascular risk factors

Ortho-Clinical Diagnostics announces availability of NEPHROCHECK Test System for AKI patients

Joslin study could lead to improved anti-aging drugs

Study provides evidence for presence of enterovirus in pancreatic islets of type 1 diabetic patients

Novartis announces FDA approval of Signifor LAR for treatment of patients with acromegaly

Children who skip meals more likely to have excess body fat, increased cardiometabolic risk

New study finds that immune cells in the brain may contribute to obesity

Figitumumab development discontinued for non-adenocarcinoma NSCLC

UR researchers on track to solve mystery of weight gain

Study finds link between hypoglycaemia and increased risk of cardiovascular events

UB study creates new awareness for diabetics who are at risk for dehydration

New interoperability standards for diabetes devices

FDA clears ArmaGen's AGT-182 IND application for treatment of Hunter syndrome

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