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Transplantation of pulmonary progenitor cells derived from hESCs promising for acute lung injury

Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells (hESCs). Findings by investigators at The University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy.

4 Feb 2010

Study: Generic nifedipine product not bioequivalent to Adalat XL

An extended release generic nifedipine product (Mylan-Nifedipine extended release 60 mg formerly Gen-Nifedipine extended release 60mg, Genpharm ULC) is not bioequivalent to the Canadian originator product, Adalat(R) XL(R), according to the results of a study recently published in the International Journal of Clinical Pharmacology and Therapeutics.

4 Feb 2010

Geisinger Health System and TGen sign research agreement

Geisinger Health System and the Translational Genomics Research Institute today announced the signing of a strategic research agreement that provides a focused look at the gaps in clinical medicine where biomedical research can make a difference.

4 Feb 2010

TGen, Geisinger Health System sign strategic research agreement

The Translational Genomics Research Institute (TGen) and Geisinger Health System today announced the signing of a strategic research agreement that provides for a focused look at the gaps in clinical medicine where biomedical research can make a difference.

4 Feb 2010

HealthSport's bi-layer edible film strip technology related patent application receives Mexican approval

HealthSport, Inc., the preeminent formulator and developer of edible, multi-layer film strips that deliver drug and dietary supplement actives through buccal and sublingual absorption as well as oral ingestion, announced today that the Mexican Institute of Industrial Property has approved HealthSport's patent application relating to its bi-layer edible film strip technology.

4 Feb 2010

Inverness Medical Innovations to acquire Kroll's Substance Abuse Testing division

Inverness Medical Innovations, Inc., a global leader in enabling individuals to take charge of their health at home through the merger of rapid diagnostics and health management, announced today that it has entered into a binding agreement with Kroll Inc., a subsidiary of Marsh and McLennan Companies, Inc. to purchase its Substance Abuse Testing division (Kroll Laboratory Specialists, Inc.), its business unit providing forensic quality substance abuse testing products and services across the United States.

4 Feb 2010

IBM announces definitive agreement to acquire Initiate Systems

IBM today announced it has signed a definitive agreement to acquire Initiate Systems, a market leader in data integrity software for information sharing among healthcare and government organizations. Initiate's software helps healthcare clients work more intelligently and efficiently with timely access to patient and clinical data. It also enables governments to share information across multiple agencies to better serve citizens.

3 Feb 2010

Keryx Biopharmaceuticals reaches agreement with FDA on SPA for Phase 3 trial of KRX-0401

Keryx Biopharmaceuticals, Inc. announced today that it has reached agreement with the U.S. Food and Drug Administration (FDA) regarding a Special Protocol Assessment (SPA) on the design of a Phase 3 trial for its PI3K/Akt pathway inhibitor, KRX-0401 (perifosine), in patients with refractory metastatic colorectal cancer.

3 Feb 2010

BRAF drugs may accelerate tumour growth in cancer patients with faulty RAS gene

A team of UK scientists has made the unexpected discovery that drugs which target a well known fault in a protein called BRAF could actually fuel the progression of cancer in some cases. The findings of this study, which was jointly funded by Cancer Research UK, The Institute of Cancer Research (ICR) and the Wellcome Trust are published in Cell.

3 Feb 2010

Penn Medicine experts available to offer medical insight and commentary during 2010 Winter Olympics

Experts from the University of Pennsylvania School of Medicine are available to offer expert medical insight and commentary during the 2010 Winter Olympics in Vancouver on issues ranging from the effects of performance enhancing drugs to concerns about the spread of novel H1N1, head trauma and more.

3 Feb 2010

Gene variants protect sexually-abused victims from alcohol dependence, says study

Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children - and therefore at high risk for alcohol problems - carry gene variants that protect them from heavy drinking and its effects, according to researchers at Washington University School of Medicine in St. Louis.

3 Feb 2010

Maximizing quality in clinical trials is emphasized at community workshop

A community workshop sponsored by SNM's Clinical Trials Network (CTN) officially kicked off on Feb. 1, in Albuquerque, N.M., and presented participants with a series of educational sessions on the use of molecular imaging in clinical trials for investigational therapeutic drugs.

3 Feb 2010

SNM Clinical Trials Network Workshop: Experts to discuss usage of molecular imaging

On Feb. 2, the final day of the second annual SNM Clinical Trials Network Workshop, experts working in various facets of the molecular imaging community met in Albuquerque, N.M., to discuss the nuts and bolts of using imaging in clinical trials and the challenges and opportunities ahead in the regulatory landscape.

3 Feb 2010

MPR drug information now available for iPhone and iPod touch

MPR – the most widely used drug reference by clinicians – is now available as a free App for the iPhone and iPod touch. The MPR drug database is also available for free for BlackBerry, Palm, and Microsoft Mobile devices, as well as desktop and laptop computers running Microsoft XP and Microsoft Vista (www.empr.com/download).

3 Feb 2010

Hundred millions for biotech-licence

Apeiron Biologics AG (Apeiron) today announced the signing of an agreement granting GlaxoSmithKline (GSK) exclusive rights to APN01 (recombinant human Angiotensin Converting Enzyme 2, rhACE2), an enzyme biotherapeutic currently in Phase 1 development for the treatment of the Acute Respiratory Distress Syndrome (ARDS).

3 Feb 2010

Hypertension drug market to decrease through 2013 due to generic erosion and few emerging therapies

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, in addition to extensive generic erosion, the hypertension drug market will be constrained through 2018 by a pipeline containing very few emerging therapies with novel mechanisms of action. Gilead's darusentan was positioned to be the next emerging therapy with a novel mechanism of action to reach the hypertension market. However, following darusentan's failure to meet its primary endpoint in the recent DORADO-AC Phase III clinical trial, further development of the agent has been terminated.

3 Feb 2010

MV vaccine prevents TB in people with HIV infection

Results from clinical trials conducted in Tanzania show that a new vaccine against tuberculosis, Mycobacterium vaccae (MV), is effective in preventing tuberculosis in people with HIV infection. Findings from the trials, which were conducted by investigators from Dartmouth Medical School in the United States, will be published in the next issue of AIDS, the leading journal in the field of HIV and AIDS research. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.

3 Feb 2010

Tips to prevent heartburn

With the Big Game approaching, many football fans across the country are preparing for viewing parties, and the non-stop eating that comes with them. But favorite football foods like pizza, wings and nachos can trigger heartburn, which can end the evening long before the last touchdown.

3 Feb 2010

Scientists are getting closer to prove how cholesterol causes heart disease

By considering molecular-level events on a broader scale, researchers now have a clearer, if more complicated, picture of how one class of immune cells goes wrong when loaded with cholesterol. The findings reported in the February 3rd issue of Cell Metabolism, a Cell Press publication, show that, when it comes to the development of atherosclerosis and heart disease, it's not about any one bad actor-it's about a network gone awry.

3 Feb 2010

Ohio changes Medicaid drug program, N.C. weighs cuts in Medicaid personal care services

The Cleveland Plain Dealer reports that Ohio's seven Medicaid managed care plans this month will make changes in the prescription drug plans that cover about 1.5 million people, although many of those beneficiaries will not face increased costs.

3 Feb 2010

Drugs News and Research

Transplantation of pulmonary progenitor cells derived from hESCs promising for acute lung injury

Study: Generic nifedipine product not bioequivalent to Adalat XL

Geisinger Health System and TGen sign research agreement

TGen, Geisinger Health System sign strategic research agreement

HealthSport's bi-layer edible film strip technology related patent application receives Mexican approval

Inverness Medical Innovations to acquire Kroll's Substance Abuse Testing division

IBM announces definitive agreement to acquire Initiate Systems

Keryx Biopharmaceuticals reaches agreement with FDA on SPA for Phase 3 trial of KRX-0401

BRAF drugs may accelerate tumour growth in cancer patients with faulty RAS gene

Penn Medicine experts available to offer medical insight and commentary during 2010 Winter Olympics

Gene variants protect sexually-abused victims from alcohol dependence, says study

Maximizing quality in clinical trials is emphasized at community workshop

SNM Clinical Trials Network Workshop: Experts to discuss usage of molecular imaging

MPR drug information now available for iPhone and iPod touch

Hundred millions for biotech-licence

Hypertension drug market to decrease through 2013 due to generic erosion and few emerging therapies

MV vaccine prevents TB in people with HIV infection

Tips to prevent heartburn

Scientists are getting closer to prove how cholesterol causes heart disease

Ohio changes Medicaid drug program, N.C. weighs cuts in Medicaid personal care services

Drug Discovery - Second Edition eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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