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New issue from Annals of Internal Medicine

Prescriptions of some opioids, such as oxycodone, have increased significantly over the past decade. As long-term opioid therapy for chronic noncancer pain becomes more common, the deaths associated with opioids increase.

19 Jan 2010

New functions in an enzyme can develop through point mutation

A new study by a research team at Uppsala University shows how new functions can develop in an enzyme. This can explain, for example, how resistance to toxins can occur so simply. The findings are now being published in the Journal of Biological Chemistry.

19 Jan 2010

SAMHSA report indicates one quarter of adolescent girls were involved in serious fights in the past year

A report by the Substance Abuse and Mental Health Services Administration (SAMHSA) indicates that, in the past year, one quarter (26.7 percent) of adolescent girls participated in a serious fight at school or work, group-against-group fight, or an attack on others with the intent to inflict serious harm.

19 Jan 2010

Genetic map of Artemisia will accelerate breeding to address increased demand for malaria treatments

Plant scientists at the University of York have published the first genetic map of the medicinal herb Artemisia annua. The map is being used to accelerate plant breeding of Artemisia and rapidly develop the species into a high-yielding crop. This development is urgently needed to help meet escalating demand for effective malaria treatments.

19 Jan 2010

The Methodist Hospital initiates program on nanotechnology in orthopedics and spine surgery

A new research program at The Methodist Hospital in Houston is the nation's first dedicated solely to advancing nanotechnology in orthopedics and spine surgery.

19 Jan 2010

EMBL-EBI hosts drug discovery database

ChEMBLdb, a vast online database of information on the properties and activities of drugs and drug-like small molecules and their targets, launches today with information on over half a million compounds. The data lie at the heart of translating information from the human genome into successful new drugs in the clinic.

19 Jan 2010

Scientists launch NEWMEDS project to develop drugs for schizophrenia and depression

An international consortium of scientists, led by H. Lundbeck A/S and King's College London, has launched one of the largest ever research academic-industry collaboration projects to find new methods for the development of drugs for schizophrenia and depression.

19 Jan 2010

Lighter sedation during spinal anesthesia reduces postoperative delirium in elderly patients

A recent study, published in the January issue of Mayo Clinic Proceedings, demonstrates that in elderly patients undergoing hip fracture repair under spinal anesthesia with propofol sedation, the prevalence of delirium can be decreased by 50 percent with light sedation, compared to deep sedation.

19 Jan 2010

New type of fat-producing cells may speed up treatments for muscular dystrophy and fibrosis

A team of University of British Columbia researchers has identified fat-producing cells that possess "dual-personalities" and may further the development of treatments for muscle diseases such as muscular dystrophy and fibrosis.

19 Jan 2010

Study examines how opioid overdose differs by prescribed dose for chronic pain conditions

More and more Americans with chronic pain not caused by cancer are taking medically prescribed opioids like Oxycontin (oxycodone) and Vicodin (hydrocodone). The January 19 Annals of Internal Medicine features the first study to explore the risk of overdose in patients prescribed opioids for chronic noncancer pain in general health care.

19 Jan 2010

"Nanoburrs" for treating cardiovascular diseases

Researchers at MIT and Harvard Medical School have built targeted nanoparticles that can cling to artery walls and slowly release medicine, an advance that potentially provides an alternative to drug-releasing stents in some patients with cardiovascular disease.

19 Jan 2010

U-M's tailored treatment more effective against heart attacks

A new study by the University of Michigan Medical School and VA Ann Arbor Health System challenges the medical thinking that the lower the cholesterol, the better.

19 Jan 2010

Tragic consequences of AIDS denialism in South Africa

Despite irrefutable proof that HIV treatments have proven benefits, AIDS denialists continue to deny their value. In a paper just published online in Springer's journal AIDS and Behavior, Professor Myron Essex and Dr. Pride Chigwedere, from the Harvard School of Public Health AIDS Initiative in the US, provide additional proof that withholding HIV treatments with proven benefits led to the death of 330,000 people in South Africa as the result of AIDS denialist policies. They also show that the harm has not been reversed and highlight that when denialism enters public health practice, as in South Africa, the consequences are disastrous.

19 Jan 2010

Blocking release of VEGFs may inhibit tumor growth

Researchers at the University of Helsinki, Finland, and the Paul Scherrer Institute (PSI) in Villigen, Switzerland, have determined the crystal structure of the ligand binding domain of a vascular endothelial growth factor (VEGF) receptor in complex with one of its ligands (VEGF-C).

19 Jan 2010

Calsed earns proprietary clinical gold standard status from Decision Resources

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Celgene/Nippon Kayaku's Calsed earns Decision Resources' proprietary clinical gold standard status in 2013 for the treatment of extensive-disease small-cell lung cancer, following its approval for the indication in 2012.

19 Jan 2010

Psoriasis therapy costs outpace inflation

Findings from a cost model suggest that expenses for systemic psoriasis therapy appear to be increasing at a faster rate than inflation, and newer biologically derived treatments are more expensive than traditional systemic therapies, according to a report in the January issue of Archives of Dermatology, one of the JAMA/Archives journals.

19 Jan 2010

AstraZeneca and Dako Denmark A/S enter into collaboration agreement

AstraZeneca and Dako Denmark A/S announced today that they have entered into a collaboration agreement to develop companion diagnostic tests for multiple AstraZeneca oncology projects, including biologics and small molecules, in various stages of discovery and development.

18 Jan 2010

NIDA researchers receive prestigious PECASE awards

Two researchers from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have been awarded the White House Office of National Science and Technology Council's Presidential Award for Early Career Scientists and Engineers (PECASE). NIDA grantees Dr. Bruce J. Hinds, III and Dr. Gonzalo E. Torres will receive their awards today during a ceremony at the Commerce Building in Washington, DC.

18 Jan 2010

ERT Knowledge Series of educational papers discusses patient safety in clinical trials

ERT, a leading provider of centralized services to the biopharmaceutical, medical device and related industries, today announced its new ERT Knowledge Series of educational papers, written by ERT experts. Each paper discusses issues relevant to patient safety in clinical trials today and further establishes ERT as an experienced and reliable partner in products and services for the clinical trials industry.

18 Jan 2010

Study reveals link between serotonin receptor number and antidepressant treatment

An excess of one type of serotonin receptor in the center of the brain may explain why antidepressants fail to relieve symptoms of depression for 50 percent of patients, a new study from researchers at Columbia University Medical Center shows.

18 Jan 2010

Drugs News and Research

New issue from Annals of Internal Medicine

New functions in an enzyme can develop through point mutation

SAMHSA report indicates one quarter of adolescent girls were involved in serious fights in the past year

Genetic map of Artemisia will accelerate breeding to address increased demand for malaria treatments

The Methodist Hospital initiates program on nanotechnology in orthopedics and spine surgery

EMBL-EBI hosts drug discovery database

Scientists launch NEWMEDS project to develop drugs for schizophrenia and depression

Lighter sedation during spinal anesthesia reduces postoperative delirium in elderly patients

New type of fat-producing cells may speed up treatments for muscular dystrophy and fibrosis

Study examines how opioid overdose differs by prescribed dose for chronic pain conditions

"Nanoburrs" for treating cardiovascular diseases

U-M's tailored treatment more effective against heart attacks

Tragic consequences of AIDS denialism in South Africa

Blocking release of VEGFs may inhibit tumor growth

Calsed earns proprietary clinical gold standard status from Decision Resources

Psoriasis therapy costs outpace inflation

AstraZeneca and Dako Denmark A/S enter into collaboration agreement

NIDA researchers receive prestigious PECASE awards

ERT Knowledge Series of educational papers discusses patient safety in clinical trials

Study reveals link between serotonin receptor number and antidepressant treatment

Drug Discovery - Second Edition eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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