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Discovery of enzyme involved in inflammatory bowel disease

Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD).

2 Jun 2009

Noninvasive screening test detects digestive cancers in multiple organs

Mayo Clinic researchers have demonstrated that a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the colon -- including pancreas, stomach, biliary and esophageal cancers. This is one of more than 100 Mayo Clinic studies being presented at Digestive Disease Week 2009 in Chicago, May 30 - June 4.

2 Jun 2009

One in ten advanced colon cancer patients worry about prescription drug costs

The vast majority of advanced colon cancer patients in a clinical trial were not concerned about the cost of prescription drugs for managing chemotherapy side effects, such as infection, pain and nausea and few adopted strategies to reduce drug cost burdens after joining the clinical trial, according to a study led by researchers at Dana-Farber Cancer Institute in Boston.

1 Jun 2009

Lower levels of PHD2 protein influence tumor growth in mice

Tumors need a healthy supply of blood to grow and spread. Researchers at the Stanford University School of Medicine have identified a molecule that regulates blood vessel growth that is often found at less-than-normal levels in human tumors. Blocking the expression of the molecule, called PHD2, allows human cancer cells to grow more quickly when implanted into mice and increases the number of blood vessels feeding the tumor.

1 Jun 2009

Inflammatory bowel disease on the rise in specific populations

Researchers are making great strides in understanding the development and treatment of inflammatory bowel disease, a chronic inflammatory condition of the digestive tract that affects more than a half million Americans, according to several studies being presented at Digestive Disease Week® 2009 (DDW®). DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

1 Jun 2009

Chemotherapy combination outcomes differ for aged, younger colon cancer patients

The combination of chemotherapies 5FU and oxaliplatin compared to 5FU alone after surgery for colon cancer decreases colon cancer recurrence and promotes longer survival for patients under 70 -- but not for those who are older, according to Mayo Clinic and Dana-Farber Cancer Institute scientists who will present their findings at the American Society of Clinical Oncology's (ASCO) annual meeting in Orlando, Fla.

1 Jun 2009

Obesity predicts inadequate bowel prep at colonoscopy

Obesity is an independent predictor of inadequate bowel preparation at colonoscopy, and the presence of additional risk factors further increases the likelihood of a poorly cleansed colon, according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.

1 Jun 2009

Surgery not necessary for most late-stage colorectal cancers

A new study shows that a large majority of patients who present with advanced colorectal cancer that has spread to other organs (stage IV) don't require immediate surgery to remove the primary tumor in the colon. Researchers from Memorial Sloan-Kettering Cancer Center (MSKCC) presented their data at the American Society of Clinical Oncology Annual Meeting.

31 May 2009

Discovery of gene associated with a three-fold increase in risk for testicular cancer

Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer.

31 May 2009

Low vitamin D levels in blacks could contribute to higher rates of cancer, other diseases, researcher says

Low vitamin D levels in blacks could contribute to health gaps between white and black U.S. residents, Michael Holick, a professor at Boston University and a vitamin D researcher, said recently, the GNS/Chicago Sun-Times reports.

28 May 2009

Novel chemotherapy and biological agents brings dramatic increase in metastatic colon cancer survival

Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a dramatic increase in survival for patients with advanced disease, according to researchers at The University of Texas M. D. Anderson Cancer Center.

26 May 2009

QIAGEN launches novel product enabling non-invasive prenatal diagnostics and cancer detection

QIAGEN today announced the launch of a novel product for extraction of free circulating fragments of tumor- and fetal-derived nucleic acids as well as viral nucleic acids in human blood. Scientists consider these DNA and RNA fragments to have great potential for the highly sensitive and non-invasive diagnosis of a wide range of diseases, including congenital disorders, malignancies such as colon and lung cancer, and infections.

From QIAGEN Manchester Limited 25 May 2009

Research suggests role of low vitamin D in cancer

In studying the preventive effects of vitamin D, researchers at the Moores Cancer Center at the University of California, San Diego, have proposed a new model of cancer development that hinges on a loss of cancer cells' ability to stick together. The model, dubbed DINOMIT, differs substantially from the current model of cancer development, which suggests genetic mutations as the earliest driving forces behind cancer.

22 May 2009

Discovery in colon cancer prevention

A new study finds that individuals who have low expression of the "Celebrex gene," 15-PGDH, are actually resistant to Celebrex treatment when used to prevent colon cancer.

18 May 2009

Computer model predicts how brain tumors grow and evolve

Researchers from Brown University and other institutions have developed a computational computer model of how brain tumors grow and evolve.

18 May 2009

Transplant patients experience worse outcomes from cancer

After comparing two patient cancer registries - one featuring transplant patients and the other the general population - researchers at the University of Cincinnati (UC) have found that transplant patients experience worse outcomes from cancer.

17 May 2009

Genetic marker predicts earlier onset of prostate cancer in Caucasian men

Fox Chase Cancer Center researchers have identified a genetic marker that is associated with an earlier onset of prostate cancer in Caucasian men who have a family history of prostate cancer. If the data are confirmed, the marker may help clinicians personalize prostate cancer screening.

17 May 2009

Medicare will not cover virtual colonoscopies, CMS Says

CMS on Tuesday announced a final decision to end Medicare coverage for virtual colonoscopies, also known as CT colonographies, the Wall Street Journal reports (Yoest, Wall Street Journal, 5/13).

13 May 2009

Anti-viral ribavirin may prove effective in treatment of many cancers

A ground-breaking Canada-wide clinical trial led by Dr. Katherine Borden, at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, has shown that a common anti-viral drug, ribavirin, can be beneficial in the treatment of cancer patients.

13 May 2009

Urologists say don’t give up on prostate cancer screening just yet

What's a guy to do? While prostate specific antigen (PSA) testing has been the standard screening tool for prostate cancer for several decades, results of a study recently published in The New England Journal of Medicine question the effectiveness of PSA screening in reducing death from prostate cancer. But many urologists argue that men should not be swayed from getting the test-it still saves lives.

13 May 2009