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Magnet guides iron-loaded cells to specific damaged sites in the heart

Optimal stem cell therapy delivery to damaged areas of the heart after myocardial infarction has been hampered by inefficient homing of cells to the damaged site. However, using rat models, researchers in France have used a magnet to guide cells loaded with iron oxide nanoparticles to key sites, enhancing the myocardial retention of intravascularly delivered endothelial progenitor cells.

27 Jun 2012

SIR/TAC combination more effective in preventing GVHD after allogeneic blood cell transplantation

Researchers at Moffitt Cancer Center have conducted a clinical trial aimed at preventing graft vs. host disease (GVHD) in patients who have received hematopoietic (blood) cell transplants (HCT). The study, comparing the drug tacrolimus (TAC) in combination with either methotrexate (MTX ) or sirolimus (SIR), found that the sirolimus/tacrolimus (SIR/TAC) combination was more effective in preventing grades II-IV acute GVHD and moderate-severe chronic GVHD after allogeneic blood cell transplantation.

27 Jun 2012

ESCs and iPSCs demonstrate similar survival and neural differentiation capabilities

Researchers in Japan who evaluated the risks and efficacy of transplanting two varieties of stem cells into mouse cochlea have concluded that both adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities.

27 Jun 2012

Poor prognosis for heart transplant patients with restenosis

Orthotopic heart transplant patients who develop in-stent restenosis after percutaneous coronary intervention have a poor long-term prognosis, research suggests.

26 Jun 2012

World-renowned pediatric cardiac surgeon performs 10,000th milestone operation

Edward L. Bove didn't know he was hitting a major milestone this spring, but the world-renowned pediatric cardiac surgeon performed his 10,000th surgery on March 27 at the University of Michigan's C.S. Mott Children's Hospital.

26 Jun 2012

New analysis finds increase in per-patient operating costs in PCMHs

The patient-centered medical home (PCMH) is a concept at the heart of many health care reform models that aim to both improve the quality of care and reduce wasteful spending. But a new analysis of federally qualified health centers finds that clinics with higher scores as medical homes also had higher per-patient operating costs.

25 Jun 2012

Deferasirox reduces elevated iron levels in patients with myelodysplastic syndrome

Researchers at Moffitt Cancer Center and colleagues at six other institutions have recently tested a treatment for patients with myelodysplastic syndrome, or MDS, a blood-related malignancy that involves the ineffective production of blood cells, leaving patients anemic and in need of frequent blood transfusions. Because the body has no natural means to reduce iron that accumulates from repeated transfusions, patients' organs can become iron overloaded, leading to heart failure, liver injury, susceptibility to infection, and other complications.

23 Jun 2012

CARHY announces comprehensive hematopoietic stem cell transplant service

Adding an impetus to the already existing image of Bangalore being a healthcare destination of India, Columbia Asia Referral Hospital, Yeshwanthpur (CARHY), announced comprehensive bone marrow transplant (stem cell transplant) service on Thursday.

23 Jun 2012

Wake Forest Baptist researchers achieve early milestone in lab-engineered kidney project

Regenerative medicine researchers at Wake Forest Baptist Medical Center have reached an early milestone in a long-term project that aims to build replacement kidneys in the lab to help solve the shortage of donor organs.

23 Jun 2012

Structured exercise programmes benefit lung transplant patients

Lung transplant patients who took part in a three-month structured exercise program when they were discharged from hospital improved their health-related quality of life and reduced their risk of cardiovascular problems.

22 Jun 2012

Parents must be considered during expansion of genetic screening programs for newborns

Parents must be considered when states decide to expand genetic screening programs for newborns, according to a new study that looked at mandatory testing panels and political pressure by advocacy groups.

22 Jun 2012

New methods to track stem cells

Researchers at the University of Liverpool have developed new methods to track stem cells and further understanding of what happens to them after they have been in the body for a significant period of time.

22 Jun 2012

Largest study to examine impact of gastric sleeve surgery on pre-transplant obese patients

Morbidly obese patients with end-stage organ failure may improve their chances for successful organ transplantation after laparoscopic sleeve gastrectomy, according to a new study presented here at the 29th Annual Meeting of the American Society for Metabolic & Bariatric Surgery (ASMBS).

21 Jun 2012

Antimicrobial exposure may increase risk of allergies in children

Exposure to common antibacterial chemicals and preservatives found in soap, toothpaste, mouthwash and other personal-care products may make children more prone to a wide range of food and environmental allergies, according to new research from Johns Hopkins Children's Center.

20 Jun 2012

AstraZeneca, Rigel enter global license agreement for R256 inhaled JAK inhibitor to treat chronic asthma

AstraZeneca and Rigel Pharmaceuticals Inc. today announced an exclusive worldwide license agreement for the global development and commercialization of R256, Rigel's inhaled JAK inhibitor shown to inhibit IL-13 and IL-4 signalling, which is being investigated as a treatment for moderate to severe chronic asthma. In preclinical research, R256 has been shown to reduce airway inflammation and improve lung function.

19 Jun 2012

Many doctors report working even when ill

An unwavering work ethic is a hallmark of many health professionals. But a new survey finds that when a doctor is sick, staunch dedication can have unintended consequences.

19 Jun 2012

Heart transplant patients who develop restenosis after receiving a stent have poor long-term survival

Heart transplant patients are notorious for developing an aggressive form of coronary artery disease that can often result in heart failure, death or the need for repeat transplantation. The condition can also have a negative impact on future cardiac procedures, such as stenting.

19 Jun 2012

Allergy risk in children linked to antibacterials in personal-care products

Exposure to common antibacterial chemicals found in soap, toothpaste, mouthwash and other personal-care products may make children more prone to a wide range of food and environmental allergies, according to new research from Johns Hopkins Children’s Center.

19 Jun 2012

Midwest patient receives successful stem cell transplant to cure sickle cell disease

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant.

19 Jun 2012

Pediatric treatment regime for ALL patients improves chances of long-term survival

Acute lymphoblastic leukemia (ALL), usually found in pediatric patients, is far more rare and deadly in adolescent and adult patients. According to the National Marrow Donor Program, child ALL patients have a higher than 80 percent remission rate, while the recovery rate for adults stands at only 40 percent.

18 Jun 2012

Transplant News and Research

Magnet guides iron-loaded cells to specific damaged sites in the heart

SIR/TAC combination more effective in preventing GVHD after allogeneic blood cell transplantation

ESCs and iPSCs demonstrate similar survival and neural differentiation capabilities

Poor prognosis for heart transplant patients with restenosis

World-renowned pediatric cardiac surgeon performs 10,000th milestone operation

New analysis finds increase in per-patient operating costs in PCMHs

Deferasirox reduces elevated iron levels in patients with myelodysplastic syndrome

CARHY announces comprehensive hematopoietic stem cell transplant service

Wake Forest Baptist researchers achieve early milestone in lab-engineered kidney project

Structured exercise programmes benefit lung transplant patients

Parents must be considered during expansion of genetic screening programs for newborns

New methods to track stem cells

Largest study to examine impact of gastric sleeve surgery on pre-transplant obese patients

Antimicrobial exposure may increase risk of allergies in children

AstraZeneca, Rigel enter global license agreement for R256 inhaled JAK inhibitor to treat chronic asthma

Many doctors report working even when ill

Heart transplant patients who develop restenosis after receiving a stent have poor long-term survival

Allergy risk in children linked to antibacterials in personal-care products

Midwest patient receives successful stem cell transplant to cure sickle cell disease

Pediatric treatment regime for ALL patients improves chances of long-term survival

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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