Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Researchers identify new risk gene for Parkinson's disease

Screening DNA of Parkinson's patients in the Christine Van Broeckhoven laboratory (VIB-UAntwerpen Center for Molecular Neurology) identified a new risk gene for Parkinson's disease. Mutations in ATP10B resulted in loss of ATP10B protein.

12 Apr 2020

Modifiable risk factors could play important role in Alzheimer's disease, study finds

Amyloid is a key feature of Alzheimer's disease, but the accumulation of these sticky proteins may not be the only risk factor for developing Alzheimer's disease, according to a new study published this week.

8 Apr 2020

OGT delivers translocation and partial tandem duplication detection with updates to SureSeq NGS portfolio

Oxford Gene Technology announces the addition of accurate detection capabilities for translocations and difficult-to-sequence partial tandem duplications.

From Oxford Gene Technology 7 Apr 2020

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.

5 Apr 2020

New study offers clues to why autism is more common in boys than in girls

A new study in Neuron offers clues to why autism spectrum disorder is more common in boys than in girls. National Institutes of Health scientists found that a single amino acid change in the NLGN4 gene, which has been linked to autism symptoms, may drive this difference in some cases.

2 Apr 2020

Key protein in sperm production could aid male infertility treatments

Researchers have discovered that a key protein drives sperm production, knowledge that may help infertile couples conceive.

26 Mar 2020

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes.

23 Mar 2020

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the study of prostate cancer patients with family histories of the disease.

23 Mar 2020

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access.

23 Mar 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Recognizing CDKL5 Deficiency Disorder

News-Medical speaks to Dr. Dan Lavery about the LouLou Foundation, a non-profit organization dedicated to CDLK5 Deficiency Disorder.

17 Mar 2020

Researchers probe how specific genes can impact early brain development

When brains begin developing, there are a lot of moving parts -- and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism.

11 Mar 2020

Abnormal retinal gene function underlying vision loss in dogs

A canine study carried out at the University of Helsinki has described a gene variant in the regulatory region of the retina resulting in the abnormal function of retinal genes and, eventually, in the loss of vision in dogs.

10 Mar 2020

Why do women live longer?

It has been a widespread belief that men live a shorter life due to lifestyle choices, such as smoking and drinking alcohol. But a new study shows that men are genetically predisposed to dying younger because their Y chromosome is unable to protect an unhealthy X chromosome.

9 Mar 2020

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

Stem cells involved in replenishing human tissues and blood depend on an enzyme known as telomerase to continue working throughout our lives. When telomerase malfunctions, it can lead to both cancer and premature aging conditions.

3 Mar 2020

Novel technique helps trace individual chromosomes during embryonic development

The spatial arrangement of genetic material within the cell nucleus plays an important role in the development of an organism.

28 Feb 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Abnormal formation and growth of the placenta is considered an underlying cause of various pregnancy complications such as miscarriages, preeclampsia and fetal growth restriction.

25 Feb 2020

Chromosomal imbalance in cancer cells can either promote or inhibit metastasis

Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes.

24 Feb 2020

DNA topological problems may cause lymphoma, study shows

Researchers from the Spanish National Cancer Research Centre, Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre, Seville, published today a paper in Nature Communications that shows that DNA topological problems may cause endogenous DNA breaks that have a causal relationship with cancer.

24 Feb 2020

Chromosome 4 News and Research

Further Reading

Researchers identify new risk gene for Parkinson's disease

Modifiable risk factors could play important role in Alzheimer's disease, study finds

OGT delivers translocation and partial tandem duplication detection with updates to SureSeq NGS portfolio

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

New study offers clues to why autism is more common in boys than in girls

Key protein in sperm production could aid male infertility treatments

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

Researchers elucidate new mechanism for controlling DNA methylation in cells

Recognizing CDKL5 Deficiency Disorder

Researchers probe how specific genes can impact early brain development

Abnormal retinal gene function underlying vision loss in dogs

Why do women live longer?

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

Novel technique helps trace individual chromosomes during embryonic development

New discovery may be useful for developing novel cancer treatments

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Chromosomal imbalance in cancer cells can either promote or inhibit metastasis

DNA topological problems may cause lymphoma, study shows

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