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Pitt scientists develop fast, efficient technique for discovering tiny antibody fragments

By capitalizing on a convergence of chemical, biological and artificial intelligence advances, University of Pittsburgh School of Medicine scientists have developed an unusually fast and efficient method for discovering tiny antibody fragments with big potential for development into therapeutics against deadly diseases.

15 Feb 2021

Scientists discover new immunotherapy target for malignant brain tumors

Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.

15 Feb 2021

Immunomodulatory drugs improve the success rate of cancer therapies

Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide, have significantly improved the therapy of hematologic malignancies such as multiple myeloma.

15 Feb 2021

Humidity created inside the face masks may help combat COVID-19

Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19.

14 Feb 2021

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

A new preprint research paper posted to the bioRxiv server demonstrates the potential of using the pre-existing protective responses to produce a broad-spectrum neutralizing response against not just SARS-CoV-2 but other future pathogens.

14 Feb 2021

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

14 Feb 2021

Scientists identify genes involved in autoimmune Addison's disease

Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition.

13 Feb 2021

LMU researchers study T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

13 Feb 2021

Targeted drug combined with immunotherapy prolongs survival in patients with advanced kidney cancer

Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

13 Feb 2021

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs).

13 Feb 2021

Study sheds light on the recurrence of herpes simplex virus

Researchers at the University of Virginia School of Medicine have shed light on what causes herpes simplex virus to flare up, explaining how stress, illness and even sunburn can trigger unwanted outbreaks.

12 Feb 2021

New article reviews how the circadian clock controls various aspects of homeostasis

Subconsciously, our bodies keep time for us through an ancient means - the circadian clock. A new University of California, Irvine-led article reviews how the clock controls various aspects of homeostasis, and how organs coordinate their function over the course of a day.

12 Feb 2021

Study shows that SRC-3 also regulates human immune T regulatory cells

A study led by researchers at Baylor College of Medicine reveals a novel role of the steroid receptor coactivator 3 (SRC-3/NCOA3), a protein crucial for steroid hormone function and a prognostic marker for aggressive human breast and other cancers.

12 Feb 2021

Researchers identify a pathway used by filoviruses to enter cells

It was once thought that Ebola and related filoviruses were more or less contained to Central Africa.

11 Feb 2021

Scientists conduct interdisciplinary study on using nanoparticles to fight leukemia

Scientists from Scientific and Educational Center & Smart Materials and Biomedical Applications under the leadership of Kateryna Levada together with colleagues from Center for Immunology and Cellular Biotechnology of the Immanuel Kant Baltic Federal University conducted a joint interdisciplinary study on the development of a new method for treating leukemia using nanomaterials.

11 Feb 2021

Immune System News and Research

Pitt scientists develop fast, efficient technique for discovering tiny antibody fragments

Scientists discover new immunotherapy target for malignant brain tumors

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

Immunomodulatory drugs improve the success rate of cancer therapies

Humidity created inside the face masks may help combat COVID-19

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Scientists identify genes involved in autoimmune Addison's disease

LMU researchers study T cell exhaustion

Targeted drug combined with immunotherapy prolongs survival in patients with advanced kidney cancer

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Study sheds light on the recurrence of herpes simplex virus

New article reviews how the circadian clock controls various aspects of homeostasis

Study shows that SRC-3 also regulates human immune T regulatory cells

Researchers identify a pathway used by filoviruses to enter cells

Scientists conduct interdisciplinary study on using nanoparticles to fight leukemia

New genetic analysis reveals biological causes of muscle weakness in older people

STING activation may be a new approach to reduce graft-versus-host disease

Variants of nine genes induce a higher risk of developing Addison's disease

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