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Blueprint for rational design of vaccines that induce desired T-cell responses

Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have conducted studies in mice to gain a new picture of how the immune system’s “killer” T cells are prompted to destroy infected cells. Their insights provide a blueprint for rational design of vaccines that induce desired T-cell responses.

27 May 2004

Research may lead to elimination of surface-induced thrombus formation

A University of Missouri-Rolla researcher’s investigation into how proteins adhere to surfaces may lead the elimination of surface-induced thrombus formation, a phenomenon known to cause blood clots in artificial arteries, valves and veins.

26 May 2004

New company is developing advanced therapeutics for stroke victims

Arizona Engineered Therapeutics Inc., a new company based on the research of three Arizona State University professors, is moving its first drug candidate closer to clinical trials.

26 May 2004

Zengen announces positive results of treatment for vaginal yeast infection

Zengen Inc. announced today positive phase I/II results for its proprietary molecule CZEN-002 for the treatment of vulvovaginal candidiasis (VVC), commonly known as vaginal yeast infection.

25 May 2004

Data suggests potential target for Alzheimer's disease treatment

Researchers from Weill Cornell Medical College and Columbia University College of Physicians & Surgeons have discovered at least one way in which beta-amyloid, the protein that forms stubborn plaques in the brains of Alzheimer's disease patients, can kill nerve cells.

25 May 2004

Researchers have isolated a protein receptor in chickens responsible for transferring antibodies from mother to offspring

Howard Hughes Medical Institute (HHMI) researchers have isolated a protein receptor in chickens that is responsible for transferring antibodies from mother to offspring - a function critical to bestowing a temporary immunity that protects the young against infection until their own immune systems begin functioning.

24 May 2004

Risk of artery plaques increased by use of HIV drugs

An Italian study has provided evidence that HIV drugs called protease inhibitors may increase the risk of artery "plaques."

15 May 2004

Viragen and University of Miami to advance anti-cancer study

Viragen, Inc. today announced that the Company extended its agreement with the University of Miami and UM/Sylvester Comprehensive Cancer Center to develop a novel form of an immune enhancing drug (IEP 11) that has shown promise in animal studies by inhibiting tumor growth in a broad range of cancers.

12 May 2004

Australian researchers are working on a vaccine to prevent rheumatic fever and rheumatic heart disease

The Queensland Institute of Medical Research (QIMR) Australia, is working on a vaccine to prevent rheumatic fever (RF) and rheumatic heart disease (RHD). Rheumatic fever and rheumatic heart disease are a secondary complication of a bacterial infection.

12 May 2004

Strategy to treat obesity through molecular liposuction

Researchers at The University of Texas M. D. Anderson Cancer Center have designed a strategy to treat obesity through “molecular liposuction.” The therapy destroys blood vessels supporting fat accumulation — causing the fat to rapidly break down and disappear.

10 May 2004

Organic superglues, disease treatments and better food flavourings

Organic superglues, disease treatments and better food flavourings: these are some of the projects where synthetic organic chemist Carol Taylor employs her skills.

5 May 2004

First imaging-based diagnostic test for living Alzheimer’s

Mayo Clinic researchers have devised a way to produce enhanced MRI (magnetic resonance imaging) pictures of the destructive brain lesions that cause Alzheimer’s disease. This advance using laboratory mice lays the foundation for the first imaging-based diagnostic test for living Alzheimer’s disease patients.

30 Apr 2004

Helix BioMedix announces positive results of comparative product anti-wrinkle study

Helix BioMedix today announced that it has completed a 12-week consumer product test comparing the company's anti-wrinkle peptide, HB168 with Renova(R), a currently marketed FDA approved product.

27 Apr 2004

Researchers make millions upon millions of drug-like peptides quickly and efficiently

Two Johns Hopkins scientists have figured out a simple way to make millions upon millions of drug-like peptides quickly and efficiently, overcoming a major hurdle to creating and screening huge "libraries" of these super-short proteins for use in drug development.

23 Apr 2004

A promising new therapy for rheumatoid arthritis

A promising new therapy for rheumatoid arthritis (RA) developed by researchers at the University of California, San Diego (UCSD) School of Medicine re-educates the body's immune system to prevent an attack against healthy joint tissue.

21 Apr 2004

Possible new treatment strategy for Alzheimer's disease

A new study in mice identifies one of the missing steps in how Alzheimer's develops and suggests a possible new treatment strategy, according to researchers at Columbia University Medical Center and Weill Cornell Medical College and their colleagues.

16 Apr 2004

Cancer-specific protein offers new target for the development of melanoma vaccine

Scientists from the Cancer Vaccine Collaborative (CVC) have discovered that the cancer-specific protein, SSX-2, induces a spontaneous immunological reaction against cancer cells in melanoma patients, offering a new target for the development of a therapeutic melanoma vaccine. SSX-2 is the prototype of the SSX family, and is part of a larger group of proteins known as cancer/testis (CT) antigens.

16 Apr 2004

Protein identification gets a speed boost

But the labor intensity of the procedure is now a thing of the past for researchers in the Oregon Health & Science University School of Medicine. The Proteomics Shared Resource, an unassuming but state-of-the-art lab on the fifth floor of OHSU's Medical Research Building, can process more than three times as many protein samples in half a day, and much of it can be done by one person.

14 Apr 2004

Protein sequences harder to predict than originally thought

Scientists have believed for decades that the sequencing of the human genome would automatically yield the sequences of proteins, the functional products of genes, and thus lead to the unraveling of the mechanisms behind human cell biology and disease.

12 Apr 2004

Gene therapy helps damaged heart cells regain strength and beat normally

Researchers at Jefferson Medical College and Duke University have used gene therapy to help damaged heart cells regain strength and beat normally again in the laboratory. The work takes the scientists one step closer to eventual clinical trials in humans.

12 Apr 2004