Messenger RNA (mRNA) News and Research

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Scientists describe detailed structure and function of the TFIID protein complex

A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today in Nature, opens new perspectives in the study of transcription and of the structure and mechanism of other large multi-protein assemblies involved in gene regulation.

9 Jan 2013

Scientists identify molecular mechanism central to development of osteoarthritis pain

Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could have major implications for future treatment of this often-debilitating condition.

28 Dec 2012

Researchers study response of living cells to artificial protein

One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniques-collectively referred to as synthetic biology-have been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes.

28 Dec 2012

Scientists design small molecules that recognize myotonic dystrophy-associated RNAs

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof of principle, in the new study the team designed a molecule that disabled the RNA causing myotonic dystrophy.

21 Dec 2012

Scientists discover new gene mechanism that appears to regulate triglyceride levels

Scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University have discovered a new gene mechanism that appears to regulate triglyceride levels.

15 Dec 2012

Fluidigm, GIS announce establishment of first single-cell genomics research center in Asia

The Genome Institute of Singapore (GIS), an institute under the umbrella of the Agency for Science, Technology and Research, and Fluidigm Corporation today announced the establishment of the first research center in Asia exclusively dedicated to accelerating the understanding of how individual cells work, and how diagnosis and treatment might be enhanced through insight derived from single cells.

15 Dec 2012

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

11 Dec 2012

Noncoding DNA sequence required for epidermal differentiation

The differentiation of human epidermis is controlled and stabilized by a long noncoding RNA termed terminal differentiation-induced noncoding RNA acting through a post-transcriptional mechanism, the results of an innovative US study indicate.

7 Dec 2012

CRP40 may have pathogenic role in schizophrenia

Gene expression of catecholamine-regulated protein 40 is dysregulated in people with schizophrenia, study findings show.

7 Dec 2012

Moderna Therapeutics closes $40M in financing

Moderna Therapeutics announced today that it has closed more than $40 million in financing to date, led by Flagship Ventures and private investors, which will be used to advance multiple programs toward clinical stage development.

6 Dec 2012

microRNAs play an important role during embryonic development

Sanford-Burnham researchers discover that microRNAs play an important role in germ layer formation-the process that determines which cells become which organs during embryonic development

3 Dec 2012

TINCR molecule plays a master role in epidermal differentiation

The surface of your skin, called the epidermis, is a complex mixture of many different cell types - each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences. Now, researchers at the Stanford University School of Medicine have identified a master regulator of this differentiation process.

2 Dec 2012

Experimental flu vaccine technique could reduce time needed to develop new shots for humans

"An experimental vaccine based on a molecule related to DNA protects animals against influenza and may one day offer an ultra-rapid way to develop new shots for humans, German scientists reported on Sunday," Reuters reports.

27 Nov 2012

Grove professor to investigate personalized therapies against breast cancer

For some time, researchers have known about disparities in diagnoses and outcomes among breast cancer patients based on race and age. However, they have been challenged to develop a set of criteria that can be used to reliably target drug delivery mechanisms based on an individual patient's tumor.

27 Nov 2012

Alnylam advances Tuschl II patent estate through the USPTO

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that the United States Patent and Trademark Office has issued Notices of Allowance for three patent applications from the company's exclusively held Tuschl II patent estate.

26 Nov 2012

mRNA vaccines offer protection against influenza A virus infections in various animal models

CureVac GmbH, a clinical stage biopharmaceutical company developing a new class of therapies and vaccines based on mRNA, and the German Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute (FLI), Germany, today announced that mRNA vaccines (RNActive) based on the company's RNA technology platform have the potential to provide effective protection against infectious diseases.

26 Nov 2012

Messenger RNA (mRNA) News and Research

Scientists describe detailed structure and function of the TFIID protein complex

Scientists identify molecular mechanism central to development of osteoarthritis pain

Researchers study response of living cells to artificial protein

Scientists design small molecules that recognize myotonic dystrophy-associated RNAs

Scientists discover new gene mechanism that appears to regulate triglyceride levels

Fluidigm, GIS announce establishment of first single-cell genomics research center in Asia

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Noncoding DNA sequence required for epidermal differentiation

CRP40 may have pathogenic role in schizophrenia

Moderna Therapeutics closes $40M in financing

microRNAs play an important role during embryonic development

TINCR molecule plays a master role in epidermal differentiation

Experimental flu vaccine technique could reduce time needed to develop new shots for humans

Grove professor to investigate personalized therapies against breast cancer

Alnylam advances Tuschl II patent estate through the USPTO

mRNA vaccines offer protection against influenza A virus infections in various animal models

Crucial link between protein synthesis and autism spectrum disorders

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

New England Biolabs launches new NEBNext Ultra kits at ASHG annual meeting

Two studies investigate role of oxygen in cell transplantation

eBook: A guide to RNA sequencing eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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