Phenotype News and Research

RSS

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

A new study revealed that the replication of the ancestral strain of SARS-CoV-2 is less efficient in nasal epithelial cells (NECs) of children.

3 Aug 2022

How do the rates of SARS-CoV-2 shedding into exhaled breath aerosol differ between individuals infected by different variants?

A recent article analyzed the SARS-CoV-2 shedding evolution in exhaled breath aerosols.

3 Aug 2022

New DNA repair vehicle used to fix a common genetic cause of hereditary kidney disease

Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair-kit. The advance developed by University of Bristol scientists is published in Nucleic Acids Research.

29 Jul 2022

Highly specialized T cells remain in blood 20 months after COVID-19

researchers analyze T-cell reactivity following recovery from COVID-19.

27 Jul 2022

Two UTHSC research teams receive CORNET Awards for novel projects

Two research teams at the University of Tennessee Health Science Center (UTHSC) have been awarded the 2022 UTHSC Collaborative Research Network (CORNET)-Functional Genomics Award. Each team will receive $50,000 to support their novel projects.

22 Jul 2022

How the Omicron variant shifted the biology of SARS-CoV-2

Researchers discuss significant antigenic changes within the spike protein of new SARS-CoV-2 VOCs like the Omicron variant.

20 Jul 2022

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

Researchers introduced a phenotypic screening assay for identifying compounds with SARS-CoV-2 inhibition potential based on caspase 3/7 activation.

20 Jul 2022

The known and proposed interactions of SARS-CoV and SARS-CoV-2 with DNA damage response pathways

Researchers reviewed the consequences of infection with sSARS-CoVs on the host DNA damage response.

19 Jul 2022

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Researchers reported on the benefit of immunity developed by previous SARS-CoV-2 infection for overcoming the age-associated decline in COVID-19 vaccine effectiveness.

18 Jul 2022

Newly characterized stem cell self-renewal factor enables continuous sperm production

Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.

15 Jul 2022

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

An article published in the journal Nature Communications describes a specific metabolic adaptation in some patients with acute myeloid leukemia affected by tandem mutations in the FLT3 gene.

13 Jul 2022

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

12 Jul 2022

What is the long-term protection against COVID-19?

A new study describes the immunologic parameters associated with protection from COVID-19.

12 Jul 2022

What is the association between PASC-AMs and the diagnosis of new-onset psychiatric illness after acute SARS-CoV-2 infections?

Researchers investigated if non-psychiatric PASC-AMs increase the risk of new-onset psychiatric illness diagnosis.

12 Jul 2022

The impact of gene amplification in virus adaptation through intermediate hosts

Researchers assessed the impact of gene amplification on cross-species adaptation.

12 Jul 2022

Persistence of SARS-CoV-2 in tissues leads to long COVID

PASC is likely the result of long-term persistence of SARS-CoV-2 in various tissues

11 Jul 2022

Paternal phenotypic, lifestyle characteristics do not play a role in preeclampsia susceptibility of their partners

Preeclampsia-; a condition that occurs in pregnancy and is characterized by high blood pressure and signs of kidney damage-;can be dangerous for both mother and baby.

7 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Synthetic molecule Pep19 helps regulate and balance key metabolic functions, study shows

A study conducted at the University of São Paulo in Brazil shows that the synthetic molecule Pep19 acts on the endocannabinoid system, which helps regulate and balance key metabolic functions, such as appetite, fat breakdown (lipolysis), and energy release.

5 Jul 2022

How does obesity affect the immune system?

A new study summarizes new findings on the immunoregulatory effects of excessive fat stores or malnutrition through Th2 cells.

4 Jul 2022

Phenotype News and Research

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

How do the rates of SARS-CoV-2 shedding into exhaled breath aerosol differ between individuals infected by different variants?

New DNA repair vehicle used to fix a common genetic cause of hereditary kidney disease

Highly specialized T cells remain in blood 20 months after COVID-19

Two UTHSC research teams receive CORNET Awards for novel projects

How the Omicron variant shifted the biology of SARS-CoV-2

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

The known and proposed interactions of SARS-CoV and SARS-CoV-2 with DNA damage response pathways

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Newly characterized stem cell self-renewal factor enables continuous sperm production

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

What is the long-term protection against COVID-19?

What is the association between PASC-AMs and the diagnosis of new-onset psychiatric illness after acute SARS-CoV-2 infections?

The impact of gene amplification in virus adaptation through intermediate hosts

Persistence of SARS-CoV-2 in tissues leads to long COVID

Paternal phenotypic, lifestyle characteristics do not play a role in preeclampsia susceptibility of their partners

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Synthetic molecule Pep19 helps regulate and balance key metabolic functions, study shows

How does obesity affect the immune system?

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Latest News