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Cigarette smoke prevents stem cells from becoming cartilage

A toxic pollutant spread by oil spills, forest fires and car exhaust is also present in cigarette smoke, and may represent a second way in which smoking delays bone healing, according to research presented at the annual meeting of the Orthopaedic Research Society in San Francisco.

4 Mar 2008

Novel mechanism found that may boost impaired function of leukemia protein

A new study led by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) reports on a novel mechanism that can enhance the function of a protein that is frequently impaired in patients with acute forms of leukemia.

3 Mar 2008

Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells

A new study provides valuable insight into a previously undescribed mechanism that regulates a prominent cancer-associated protein.

28 Feb 2008

Understanding primate evolution could aid HIV research

Evolution moves in fits and starts, shaping species through random genetic mutations that can help them survive or even hasten their death.

28 Feb 2008

Single microRNA plays role in innate immune response

Over the last few years scientists have discovered hundreds of microRNAs - tiny RNAs that regulate the expression of protein-coding genes.

20 Feb 2008

Scientists shed light on long-distance signaling in developing neurons

A longstanding puzzle in neurodevelopment may have yielded up a key secret.

20 Feb 2008

New key finding in neurodevelopment

A longstanding puzzle in neurodevelopment may have yielded up a key secret. A team led by scientists at Weill Cornell Medical College says they have determined how events at the very tips of the developing neuron's long, skinny axon affect gene transcription back in the cell's distant nucleus.

20 Feb 2008

Stanford researchers make first direct observation of 3-D molecule folding in real time

All the crucial proteins in our bodies must fold into complex shapes to do their jobs.

18 Feb 2008

Oncoproteins double-team and destroy vital tumor-suppressor

Two previously unconnected cancer-promoting proteins team up to ambush a critical tumor suppressor by evicting it from the cell's nucleus and then marking it for death by a protein-shredding mechanism, a team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Feb. 10 issue of Nature Cell Biology.

17 Feb 2008

Scientists solve structure of gene regulator that plays key role in cancer

Scientists at The Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans.

14 Feb 2008

Location location location, even for genes

Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in the journal Nature.

14 Feb 2008

Gene regulators bind promiscuously, but often do nothing

Biologists are developing ever more sophisticated means to characterize molecular interactions in living systems.

13 Feb 2008

MIT applies engineering approach to studying biological pathways

An MIT team has used an engineering approach to show that complex biological systems can be studied with simple models developed by measuring what goes into and out of the system.

7 Feb 2008

Disrupted genetic regulation causes common disturbance in metabolism of fat

The disease familial combined hyperlipidemia (FCH) is a common cause of disturbed metabolism of fat and early heart attacks.

7 Feb 2008

Disrupted genetic regulation causes common disturbance in metabolism of fat

The disease familial combined hyperlipidemia (FCH) is a common cause of disturbed metabolism of fat and early heart attacks.

5 Feb 2008

Why your fertility cells must have 'radio silence'

Researchers in Kobe, Japan, and Montreal, Canada, have uncovered a previously unknown mechanism which causes embryonic germ cells which later develop into sperm or ova to go through a period of "transcriptional silence," during which information from the cell's DNA cannot be copied.

31 Jan 2008

Protein that controls hair growth also keeps stem cells slumbering

Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently.

25 Jan 2008

Cigarettes leave deadly path by purging protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

24 Jan 2008

Smoking wipes out protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

21 Jan 2008

Scientists uncover role of cancer stem cell marker: controlling gene expression

Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread.

18 Jan 2008