Proliferation News and Research

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Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

Discovery of new gene that protects against lung cancer

Cancer Research UK scientists have discovered a new gene that protects against lung cancer, according to a study published in the journal PNAS.

9 Nov 2004

After stopping drinking, the brain grows back - significant implications for treatment of alcoholism during recovery

University of North Carolina at Chapel Hill scientists have reported - for the first time - a burst in new brain cell development during abstinence from chronic alcohol consumption.

8 Nov 2004

Celebrex may one day be used to prevent and even treat breast tumors

The anti-inflammatory drug Celebrex, or celecoxib, reduces tumor mass by encouraging cell death and discouraging both cell proliferation and the sprouting of new blood vessels that feed growing tumors, according to a study reported in the November issue of Molecular Cancer Research.

5 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

Protein important to nerve development serves the dual purpose of stimulating the growth of blood vessels

The discovery opens the possibility that blood vessel growth (angiogenesis) one day may be induced, or stymied, for therapeutic use against heart disease, cancer, and other illnesses, according to Dean Y. Li, M.D., Ph.D., associate professor of internal medicine in the U of U School of Medicine's Division of Cardiology.

1 Nov 2004

Fatbuster drug targets obesity

A new drug to combat obesity at a cellular level is in the sights of a University of Queensland scientist.

25 Oct 2004

High levels of a protein called LRP6 can make cancer cells more aggressive

The protein's ability to enhance tumor development suggests that the gene that codes for LRP6 is an oncogene--a gene that contributes to tumor development when overactivated.

25 Oct 2004

Potential new protein marker for prognosis of breast and ovarian cancer

The researchers matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with a better clinical outcome in both cancer types.

24 Oct 2004

Common antibacterial and antifungal ingredient used in tooth paste may protect against skin cancer

According to new studies, sanguinarine was shown to enhance production of proteins that induce cell death, or apoptosis, in cells damaged by ultraviolet-B (UVB) radiation.

21 Oct 2004

Study will evaluate arsenic exposure from the environment and its potential carcinogenic effects

The National Cancer Institute has awarded the Arizona Cancer Center at the University of Arizona Health Sciences Center a three-year grant to evaluate associations between elevated arsenic exposure and cancer incidence in Arizona and Mexico.

19 Oct 2004

New genetic mechanism has been identified linking diet to breast cancer

Experiments carried out by scientists at the Universitat Autònoma de Barcelona on experimentally induced breast cancer tumours in laboratory rats show that an excess of certain fats in the diet, commonly known as omega-6, accelerates breast cancer, increasing the malignancy of the disease.

18 Oct 2004

Researchers stimulate the body to repair tissue damaged by peripheral arterial obstructive disease

Duke University Medical Center researchers have shown that they can stimulate the body to produce its own naturally occurring growth factors to promote blood vessel growth into tissue damaged by peripheral arterial obstructive disease (PAOD).

13 Oct 2004

Discovery of a central memory form of helper T cells that can offer immunity to leishmaniasis

Researchers at the University of Pennsylvania have discovered a "central memory" form of "helper" T cells that can offer immunity to leishmaniasis, a disease that causes considerable death and disfigurement across the globe and has been found in U.S. military personnel returning from Afghanistan and Iraq.

8 Oct 2004

International society agrees that the potential of stem cells derived from fat show promising clinical uses

While questions still remain about the nature and function of stem cells found in fat, a group of researchers and clinicians convened today in Pittsburgh at the Second Annual Meeting of the International Fat Applied Technology Society (IFATS) agreed that research should move forward with the ultimate goal of performing human clinical trials to test the cells' therapeutic potential for specific indications.

5 Oct 2004

Significant progress in development of an animal model of smallpox that closely resembles human disease

Scientists have made significant progress in developing an animal model of smallpox that closely resembles human disease, which will be necessary for testing of future vaccines and potential treatments.

5 Oct 2004

Researchers discover new mechanism responsible for blood vessel tumors that cause facial deformities

Researchers have discovered a new mechanism responsible for the growth of blood vessel tumors that can cause facial deformities in infants and young children, paving the way for an antibody-based treatment to remove cells that fuel the tumors’ growth.

5 Oct 2004

A revolutionary approach to angiogenesis could make cancer treatment more effective at killing tumours

Dr. Olivier Feron and his team from the University of Louvain Medical School in Brussels have turned the whole concept of targeting tumour blood vessels on its head. Instead of the conventional approach of trying to starve tumour cells of the blood supply they need to grow, they are doing the opposite – opening up the tumour blood supply to allow better access for cancer drugs and more effective radiotherapy.

30 Sep 2004

Scientists embark on a five-year study of the effects of soy isoflavones found in dietary supplements on various body tissues

A multidisciplinary team of scientists at the University of Illinois at Urbana-Champaign is embarking on a comprehensive five-year study of the effects of soy isoflavones found in dietary supplements on various body tissues.

29 Sep 2004

Proliferation News and Research

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Discovery of new gene that protects against lung cancer

After stopping drinking, the brain grows back - significant implications for treatment of alcoholism during recovery

Celebrex may one day be used to prevent and even treat breast tumors

STAT3 protein could lead to new ways to prevent skin cancer

Protein important to nerve development serves the dual purpose of stimulating the growth of blood vessels

Fatbuster drug targets obesity

High levels of a protein called LRP6 can make cancer cells more aggressive

Potential new protein marker for prognosis of breast and ovarian cancer

Common antibacterial and antifungal ingredient used in tooth paste may protect against skin cancer

Study will evaluate arsenic exposure from the environment and its potential carcinogenic effects

New genetic mechanism has been identified linking diet to breast cancer

Researchers stimulate the body to repair tissue damaged by peripheral arterial obstructive disease

Discovery of a central memory form of helper T cells that can offer immunity to leishmaniasis

International society agrees that the potential of stem cells derived from fat show promising clinical uses

Significant progress in development of an animal model of smallpox that closely resembles human disease

Researchers discover new mechanism responsible for blood vessel tumors that cause facial deformities

A revolutionary approach to angiogenesis could make cancer treatment more effective at killing tumours

Scientists embark on a five-year study of the effects of soy isoflavones found in dietary supplements on various body tissues

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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