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Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

A new study describes a small molecule referred to as RG10 that may have potent antiviral activity against SARS-CoV-2 in human cells.

16 Sep 2021

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

In a study published on the preprint server medRxiv*, scientists studying the SARS-CoV-2 genome have identified a region linked with the disease severity.

16 Sep 2021

Single dose of typhoid conjugate vaccine found to be safe and effective in Malawian kids

A new study, published today in the New England Journal of Medicine, finds a single dose of typhoid conjugate vaccine (TCV) – the only typhoid vaccine licensed for children as young as 6 months – is safe and 84 percent effective in protecting against typhoid in Blantyre, Malawi.

16 Sep 2021

Scientists develop predictive computer model to alert surges in COVID-19 infections and mortalities

A team of scientists from Nanyang Technological University, Singapore (NTU Singapore) has developed a predictive computer model that, when tested on real pandemic data, proposed strategies that would have reduced the rate of both COVID-19 infections and deaths by an average of 72 percent, based on a sample from four countries.

16 Sep 2021

Multiple factors influence the extent to which African countries are affected by Covid-19, study shows

Countries in Africa assessed as being least vulnerable to an epidemic were the worst affected by Covid-19, new research suggests.

16 Sep 2021

Vaccination of children before school reopening may control COVID-19 pandemic

A team has recently explored the impact of non-pharmaceutical control measures and vaccination on the COVID-19 pandemic during school reopening in England.

15 Sep 2021

Study reveals role of globalization and zoonosis in the emergence and spread of SARS-CoV-2 variants

A recent study aimed to use their own classification of different SARS-CoV-2 lineages that would help monitor their genetic features and geographical origins.

14 Sep 2021

Study finds substantial decline in physical, cognitive, or psychological health among older people

Up to three quarters of older individuals in Latin America, India and China experienced significant decline in physical, cognitive, or psychological health over a three- to five-year period, according to a study published September 14th in PLOS Medicine by Martin Prince and A. Matthew Prina of King's College London, and colleagues.

14 Sep 2021

Pregnancy complications with COVID-19

An important new article published in the Clinical Medicine Journal discusses pregnancy complicated with COVID-19.

14 Sep 2021

Prior symptomatic COVID-19 enhances mRNA vaccine response

A new paper describes the antibody responses in people who have already been infected with SARS-CoV-2 and are vaccinated as compared to the naïve.

14 Sep 2021

Researchers explore the impact of venous thromboembolism during surgery for renal cell carcinoma

Venous thromboembolism (VTE) refers to blood clots in the veins, which is a serious yet preventable medical condition and is often seen with advanced cancers.

14 Sep 2021

Convalescent plasma shows no benefit in hospitalized COVID-19 patients

A new paper describes the results of a randomized controlled trial of CP in adult COVID-19 patients on oxygen when used within 12 days of the onset of respiratory symptoms.

14 Sep 2021

COVID-19 lockdown linked to improved glycemic control in type 1 diabetes

A new study looks at changes in the glycemic control in patients with diabetes during the lockdowns implemented to deal with the COVID-19 pandemic.

13 Sep 2021

The comparative effectiveness of neutralizing monoclonal antibodies against SARS-CoV-2

A study investigated the comparative efficacy of neutralizing monoclonal antibodies against SARS-CoV-2.

13 Sep 2021

Low-dose CT lung cancer screening linked to reduction in lung cancer mortality

Low-dose CT lung cancer screening is associated with a 16 percent relative reduction in lung cancer mortality, when compared against a non-LDCT control arm, according to research presented by Professor John Field and the United Kingdom Cancer Screening Trial (UKLS) Team today at the IASLC 2021 World Conference on Lung Cancer. The research will be published in the Lancet Regional Health-Europe.

13 Sep 2021

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

Scientists were inspired by the robust serum nAb responses in people who recovered from natural SARS-CoV-2 infection and were later vaccinated using mRNA vaccine. They isolated and characterized bnAbs from two COVID-19 convalescent donors who were recently vaccinated. These isolated bnAbs were found to be highly potent against sarbecoviruses. This research is available on the bioRxiv* preprint server.

13 Sep 2021

New online tool to predict mortality risk for patients with acute-on-chronic liver failure

For patients with chronic liver disease, the onset of acute-on-chronic liver failure (ACLF) instantly alters the transplant question from 'if' to 'when'. 60 to 70% of patients with ACLF die within 3 months due to poor liver function and multiple organ failure.

13 Sep 2021

Acid pH enhances SARS-CoV-2 infection by up-regulating ACE2 receptor

A new study published in the journal Frontiers of Medicine indicated that Barrett's esophagus (BE) and gastroesophageal reflux disease (GERD) may represent novel comorbidities associated with SARS-CoV-2 disease. A previous study had estimated that in the United States, 5.6% of adults have BE, a disease where esophageal squamous mucosa gets damaged by GERD.

12 Sep 2021

COVID-19 vaccines effective at preventing hospitalizations caused by the Delta variant

COVID-19 vaccines are effective at preventing hospitalizations and emergency department visits caused by the Delta variant, according to data from a national study.

12 Sep 2021

Mortality News and Research

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

Single dose of typhoid conjugate vaccine found to be safe and effective in Malawian kids

Scientists develop predictive computer model to alert surges in COVID-19 infections and mortalities

Multiple factors influence the extent to which African countries are affected by Covid-19, study shows

Vaccination of children before school reopening may control COVID-19 pandemic

Study reveals role of globalization and zoonosis in the emergence and spread of SARS-CoV-2 variants

Study finds substantial decline in physical, cognitive, or psychological health among older people

Pregnancy complications with COVID-19

Prior symptomatic COVID-19 enhances mRNA vaccine response

Researchers explore the impact of venous thromboembolism during surgery for renal cell carcinoma

Convalescent plasma shows no benefit in hospitalized COVID-19 patients

COVID-19 lockdown linked to improved glycemic control in type 1 diabetes

The comparative effectiveness of neutralizing monoclonal antibodies against SARS-CoV-2

Low-dose CT lung cancer screening linked to reduction in lung cancer mortality

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

New online tool to predict mortality risk for patients with acute-on-chronic liver failure

Acid pH enhances SARS-CoV-2 infection by up-regulating ACE2 receptor

COVID-19 vaccines effective at preventing hospitalizations caused by the Delta variant

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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