Cancer Immunotherapy News and Research

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Novel agent shown to have dual mechanism of action to eliminate cancer

Results from a study spearhead by researchers at the Vall d´Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T Cells to hone in on and eliminate cancer.

11 Jun 2019

Complex molecular conversation is key to the establishment of 'hot tumor'

A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells.

11 Jun 2019

Researchers propose a new look at the role of ferroptosis in cancer development

Professor of Ghent University and Lead Researcher at the Institute of Biology and Biomedicine of the Lobachevsky University Dmitri Krysko together with scientists from Germany, Professor Marcus Conrad and Professor Jose Pedro Friedmann Angeli recently published an article in the journal Nature Reviews Cancer, one of the highest-rated journals that occupies the 2nd line in the oncology section among 223 journals in this category and has an impact factor of 42.78 according to WoS data.

7 Jun 2019

Three-drug combination could be effective therapy for people with advanced melanoma

A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma.

7 Jun 2019

Research reveals immunomodulatory role of ent-kaurane diterpenoids toward NK cells

As early responders in the surveillance of malignant cells, natural killer cells play a significant role in the control of transformed cells at the tumor initiation stage through direct cytolysis. For this reason, NK cell-based immunotherapy is a potential therapeutic strategy for tumor sufferers.

31 May 2019

Genetically eliminating TOX factors improves eradication of solid tumors in CAR T model

A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack.

28 May 2019

Unexpected role of junk RNA in cancer opens new way for treatment of the disease

In an article just published by Trends in Cancer online, Dr. Alan Herbert, founder at InsideOutBio, highlights how the way cancer cells solve the problem of junk RNA makes them vulnerable to a new type of cancer therapy.

7 May 2019

Researchers win $6.2 million grant to study HIV/TB co-infection in children

About a third of us are walking around with the bacteria that causes tuberculosis in our bodies, but most don't actually end up with TB. For children living with HIV - about 2 million at last estimate - it's a different story.

1 May 2019

Angiotensin receptor blockers could improve response to cancer immunotherapy

A research team led by investigators at Massachusetts General Hospital and the Massachusetts Institute of Technology has found that combining a specialized version of an antihypertension drug with immune checkpoint blockers could increase the effectiveness of cancer immunotherapies.

30 Apr 2019

Patients on immunotherapies should consume more fiber, fewer probiotics

A new study has found that taking probiotics could drastically reduce the response of cancer patients to immunotherapy. Patients on a fiber-rich diet showed a five-fold increase in response.

5 Apr 2019

UC San Diego Health treats first cancer patient with iPSC-derived cell therapy

After 10 years in remission, Derek Ruff's cancer returned, this time as stage IV colon cancer. Despite aggressive rounds of chemotherapy, palliative radiotherapy and immunotherapy, his disease progressed.

2 Apr 2019

Pitt study sheds light on how immune cells help tumors to escape body's defenses

New research from the University of Pittsburgh School of Medicine and the UPMC Hillman Cancer Center sheds light on how tumors use the body's regulators of immunity for their own benefit.

2 Apr 2019

ETH researchers take major step towards personalized cancer immunotherapy

Cells belonging to the body's own immune system can help fight tumours. For several years now, this has allowed oncologists to use medications known as checkpoint inhibitors to encourage T cells to eliminate tumor cells.

30 Mar 2019

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule is safe and nontoxic in mice and can significantly delay tumor formation and growth.

28 Mar 2019

ACROBiosystems collaborates with ProMab Biotechnologies to develop immunotherapy products

ACROBiosystems, a leading manufacturer of recombinant proteins, announced that they have signed a collaboration agreement with ProMab Biotechnologies, a leading manufacturer of monoclonal antibodies and CAR-T cells.

From ACROBiosystems 7 Mar 2019

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice.

20 Feb 2019

Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

Sleep could be the best medicine to fight off an infection

Sleep has been underrated as the best medicine to fight off disease say researchers working on a new study. The study titled, “Gαs-Coupled Receptor Signaling and Sleep Regulate Integrin Activation of Human Antigen-Specific T Cells,” was published this week in the Journal of Experimental Medicine.

14 Feb 2019