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Alteration of steroid receptor genes creates fat burning muscle

The Salk Institute scientist who earlier discovered that enhancing the function of a single protein produced a mouse with an innate resistance to weight gain and the ability to run a mile without stopping has found new evidence that this protein and a related protein play central roles in the body's complex journey to obesity and offer a new and specific metabolic approach to the treatment of obesity related disease such as Syndrome X (insulin resistance, hyperlipidemia and atherosclerosis).

4 Apr 2005

EvoGenix expands capabilities through US acquisition

EvoGenix and Absalus own complementary technologies which, when combined, are capable of streamlining the identification of new antibody drug candidates and improving the development of safe and effective human therapeutic antibodies.

4 Apr 2005

Need for pediatricians to partner with community-based organizations

Pediatricians must look beyond the walls of the examining room and into their own communities to understand and confront the socioeconomic and environmental threats to the health of children and adolescents, such as poor nutrition, exposure to violence, and substance abuse.

4 Apr 2005

New antipsychotic drug prevents brain loss in schizophrenia

A new brain imaging study of recently diagnosed schizophrenia patients has found, for the first time, that the loss of gray matter typically experienced by patients can be prevented by one of the new atypical antipsychotic drugs, olanzapine, but not by haloperidol, an older, conventional drug.

4 Apr 2005

Scientists find how pneumonia bacteria get sugar boost to survive

Meningitis and pneumonia bacteria smash into our lungs and cells to steal sugar, which helps them survive, according to research presented from King's College and Guy's Hospital London, (Monday, 04 April 2005) at the Society for General Microbiology's 156th Meeting at Heriot-Watt University, Edinburgh.

4 Apr 2005

Ranbaxy settles NHS generic drug claim

Britain's Department of Health and Ranbaxy (UK) Ltd have jointly announced settlement of the claims brought against Ranbaxy for alleged anti-competitive cartel conduct in connection with the supply to the NHS of generic drugs between 1996 and 2000.

4 Apr 2005

Glaxo's CEO must answer questions in AIDS drug patent piracy case

A California federal court has ruled that GlaxoSmithKline's (GSK) Chief Executive Officer, Jean-Pierre Garnier, must answer further questions in a deposition in a patent piracy lawsuit brought against the British drug giant over GSK's patent for AZT (Retrovir), the first AIDS drug.

4 Apr 2005

Chemoembolization, first-line treatment for liver cancer

New research by Jeff Geschwind, M.D., director of interventional radiology and associate professor at Johns Hopkins University School of Medicine, has shown that liver cancer patients, most of whom have inoperable tumours, could benefit from chemoembolization, a nonsurgical treatment option that delivers a high-dose of chemotherapy to the tumour while decreasing blood flow through the arteries feeding the tumour, known as embolization.

4 Apr 2005

Meth abuse and curbs on cold medicines

As states and Congress rush to put common cold, cough and allergy drugs behind the pharmacy counter to curb illegal methamphetamine production, no one has asked consumers what they think about these restrictions -- until now. Harris Interactive asked nearly 3,000 consumers about these and related issues in a national survey commissioned by the National Consumers League (NCL) and Food Marketing Institute (FMI).

4 Apr 2005

New ion channel drug targets to emerge in pharmaceutical discovery

The identification and structural determination of channel proteins, and their validation as therapeutic targets using high throughput cell based and multiplexed screening technologies, have furnished an increase role for ion channel targets in the drug discovery and development pipelines in the pharmaceutical and biotechnology industries.

4 Apr 2005

Brain region recovery possible in former methamphetamine users

Adaptive changes in chemical activity in certain regions of the brain of former methamphetamine users who have not used the drug for a year or more suggest some recovery of neuronal structure and function, according to an article in the April issue of Archives of General Psychiatry.

4 Apr 2005

New chemicals to inhibit HIV infection

In corporation with peers from the Mount Sinai School of Medicine, New York University, researchers from the University of Science and Technology of China (USTC), a CAS affiliate, have come up with new chemical inhibitors against HIV reproduction, marking a significant progress in the development of anti-AIDS drugs based on natural host resistance.

4 Apr 2005

Tumour Necrosis Factor alpha (TNF-alpha) blocking agents cause skin disease

Members of the second most important family of drugs used to treat rheumatoid arthritis can cause serious dermatological conditions in a quarter of patients under treatment, reveals a study published in the journal Arthritis Research and Therapy.

3 Apr 2005

Inexpensive treatment stops multi-drug resistant TB in its tracks

A standard and inexpensive tuberculosis treatment regimen cut the overall TB rate in half and lowered the rate of drug-resistant cases even more dramatically in a remote Mexican health district with a high prevalence of the disease.

3 Apr 2005

Chronic pain treatments more effective when taken together

People suffering from chronic, debilitating pain caused by nerve damage or disease report better pain relief at lower doses of a combined drug treatment than from either drug administered individually, a new Queen’s study funded by the Canadian Institutes of Health Research (CIHR) shows.

3 Apr 2005

Cannabis-based medicines given in a highly-controlled clinical environment unexpectedly lead to strong psychotic effects

Volunteers taking cannabis-based therapeutic drugs as part of a controlled trial, which had been approved by an ethics board as safe for the subjects, experienced psychotic effects just as strong as if they had smoked cannabis. These findings, highly unexpected in such a controlled environment, are published today in the peer-reviewed, Open Access journal BMC Psychiatry.

3 Apr 2005

Blood pressure control suggests new approach to hypertension therapy

The kidneys have long been known to play a major role in many cases of high blood pressure, but a new study by researchers at Duke University Medical Center reveals that the body's control of blood pressure depends as much on other organs in the body.

3 Apr 2005