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Signaling molecule involved in osteoarthritis identified

Using naturally-occurring mutant mice with a defective collagen gene, scientists at Harvard have identified a signaling molecule involved in one of the most common causes of disability among the elderly in the United States, osteoarthritis.

4 Jan 2005

Chronic constipation is uncomfortable, but not dangerous

There are a lot of common myths about constipation treatment. An article in the January issue of The American Journal of Gastroenterology dispels those myths and clears numerous misconceptions regarding chronic constipation.

4 Jan 2005

The rise in over the counter drugs, why?

Switching of prescription drugs to over the counter availability is increasingly common, but what are the motives behind this trend, ask US researchers in this week's BMJ?

3 Jan 2005

Eli Lilly aware in the 1980s that fluoxetine had troubling side effects

The BMJ has turned over confidential drug company documents that went missing from a 10 year old murder case to the US Food and Drug Administration (FDA) for review.

3 Jan 2005

New painkiller was discovered in natural form in venomous snails in 1979

The natural form of Prialt – a new drug for severe pain approved this week by the U.S. Food and Drug Administration – was discovered at the University of Utah in 1979 by an incoming freshman studying toxins produced by cone snails.

30 Dec 2004

Pegaptanib (Macugen) is an effective treatment for neovascular age-related macular degeneration

Results from two concurrent, prospective, double-blind, multi-center clinical trials show that pegaptanib (Macugen), an anti-vascular endothelial growth factor therapy, is an effective treatment for neovascular age-related macular degeneration (AMD), according to a paper in the Dec. 30 issue of the New England Journal of Medicine. Macugen was approved by the Food and Drug Administration on Dec. 17.

30 Dec 2004

Moderate physical exercise can stave off metabolic syndrome in people age 55 to 75

Researchers at Johns Hopkins have determined that in people age 55 to 75, a moderate program of physical exercise can significantly offset the potentially deadly mix of risk factors for heart disease and diabetes known as the metabolic syndrome.

30 Dec 2004

Is open source the answer for finding cures for tropical diseases?

Only about 1% of newly developed drugs are for tropical diseases, such as African sleeping sickness and dengue fever. While patent incentives have driven commercial pharmaceutical companies to make Western health care the envy of the world, the commercial model only works if companies can sell enough patented products to cover their R&D costs and produce profits for shareholders.

28 Dec 2004

Information submitted via new drug applications could easily be made accessible to the public

A researcher at Oregon Health & Science University and the Portland Veterans Affairs Medical Center is calling upon the U.S. Food and Drug Administration (FDA) to share more information provided by pharmaceutical companies regarding their clinical drug trials.

28 Dec 2004

Indian curry may be the next Alzheimer's weapon

A dietary staple of India, where Alzheimer's disease rates are reportedly among the world's lowest, holds potential as a weapon in the fight against the disease.

28 Dec 2004

Lessons learned from troubles with COX-2 inhibitors

One of the nation’s leading cardiovascular medical researchers has issued a call for less aggressive direct-to-consumer advertising and better safety assurances of medications in a special article posted online by JAMA because of its relevance to the recent withdrawals and warning labels on the pain-relieving drugs known as COX-2 inhibitors.

28 Dec 2004

Speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone

Inspecting the cervix with a bright light technology called speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone, according to a new review of studies about the procedure.

28 Dec 2004

Laser therapy may be considered by arthritis patients as a safe Vioxx alternative

Adverse events of long term medication with NSAIDs and particularly coxibs, has recently received much attention in the Vioxx matter. Consequently, Vioxx has been withdrawn and Prexige has been withheld from the market. The whole group of coxibs, are now under special observation by drug agencies in both Europe and the United States.

27 Dec 2004

FDA go ahead for first of kind genetic lab test

The U.S. Food and Drug Administration (FDA) has approved the marketing of the first laboratory test system that will allow physicians to consider unique genetic information from patients in selecting medications and doses of medications for a wide variety of common conditions such as cardiac disease, psychiatric disease, and cancer.

27 Dec 2004

Update on world antimalarial drug supply

On 8 November, the World Health Organization (WHO) announced a shortfall of artemether + lumefantrine, an artemisinin-based combination therapy (ACT) used to treat malaria, for the period between November 2004 and March 2005

26 Dec 2004

Supply problem with the opiate painkiller, diamorphine

The UK Department of Health has advised the NHS that there is a supply problem with the opiate painkiller, diamorphine, and that stocks may rapidly reach a critical level in the next few weeks.

26 Dec 2004

Public health advisory for the use of non-steroidal anti-inflammatory drug products

The Food and Drug Administration (FDA) has issued a Public Health Advisory summarizing the agency's recent recommendations concerning the use of non-steroidal anti-inflammatory drug products (NSAIDs), including those known as COX-2 selective agents.

23 Dec 2004

May soon be possible to identify people at risk and even to treat a heart problem with a drug that works on the brain

Sudden cardiac death from emotional stress may be triggered by uneven signals from the brain to the heart, according to a study by University College London (UCL) scientists published in the January issue of Brain.

23 Dec 2004

Why hair turns grey

Few things about growing older are as inevitable and obvious as "going gray," yet scientists have been unable to explain the precise cause of this usually unwelcome transformation.

23 Dec 2004

Researchers can now inexpensively program the chemical synthesis of entire genes on a single microchip

Devices the size of a pager now have greater capabilities than computers that once occupied an entire room. Similar advances are being made in the emerging field of synthetic biology at the University of Houston, now allowing researchers to inexpensively program the chemical synthesis of entire genes on a single microchip.

23 Dec 2004

Drugs News and Research

Signaling molecule involved in osteoarthritis identified

Chronic constipation is uncomfortable, but not dangerous

The rise in over the counter drugs, why?

Eli Lilly aware in the 1980s that fluoxetine had troubling side effects

New painkiller was discovered in natural form in venomous snails in 1979

Pegaptanib (Macugen) is an effective treatment for neovascular age-related macular degeneration

Moderate physical exercise can stave off metabolic syndrome in people age 55 to 75

Is open source the answer for finding cures for tropical diseases?

Information submitted via new drug applications could easily be made accessible to the public

Indian curry may be the next Alzheimer's weapon

Lessons learned from troubles with COX-2 inhibitors

Speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone

Laser therapy may be considered by arthritis patients as a safe Vioxx alternative

FDA go ahead for first of kind genetic lab test

Update on world antimalarial drug supply

Supply problem with the opiate painkiller, diamorphine

Public health advisory for the use of non-steroidal anti-inflammatory drug products

May soon be possible to identify people at risk and even to treat a heart problem with a drug that works on the brain

Why hair turns grey

Researchers can now inexpensively program the chemical synthesis of entire genes on a single microchip

Drug Discovery - Second Edition eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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