Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).

29 Jun 2020

New, five-minute urine test measures the health of a person's diet

Scientists have completed large-scale tests on a new type of five-minute urine test that measures the health of a person's diet, and produces an individual's unique urine 'fingerprint'.

22 Jun 2020

Study identifies a previously unknown mechanism that contributes to intestinal cancer

A MedUni Vienna study group has identified a previously unknown mechanism involved in the development of intestinal cancer: The bacterial microbiome activates the so-called immune checkpoint Ido1 in Paneth cells, a special cell that is only found in the gastrointestinal tract, thereby preventing local intestinal inflammation.

18 Jun 2020

High-salt diet may modulate the gut microbiome

Particularly in females with untreated hypertension, reducing salt intake to what's considered a healthier level appears to be good for both their gut microbiome and their blood pressure, scientists report.

9 Jun 2020

Drug offers hope for patients with primary hyperoxaluria type 1

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder that begins in childhood and adolescence.

8 Jun 2020

New insights into how parenteral oil emulsions prevent liver disease in preterm babies

Infants born prematurely may require parenteral or intravenous nutrition to provide the necessary nourishment, as their digestive system is immature and cannot digest nutrients.

4 Jun 2020

Cognitive aptitudes of young women may be more affected with high alcohol use than men

Female college students appear to be more affected by high alcohol use than men, which may lead to less interest in academics, according to new research including by faculty at Binghamton University, State University of New York.

1 Jun 2020

High-throughput analysis of blood plasma could help identify biomarkers for ALS

High-throughput analysis of blood plasma could aid in identification of diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis (ALS), according to research from North Carolina State University.

29 May 2020

New technology developed to map cholesterol metabolism in the brain

A team of researchers led by Swansea University have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments.

29 May 2020

Researchers identify risk factors for fatty liver disease

Researchers at Massachusetts General Hospital have uncovered an unexpected connection between an imbalance of electrons in liver cells and many metabolic problems that increase the risk for conditions such as cardiovascular disease and fatty liver disease.

29 May 2020

New Orbitrap Exploris 120 mass spectrometer redefines productivity in small molecule applications

Scientists working across small molecule applications require systems that support extensive, in-depth analysis of multiple complex samples, while simultaneously increasing output and decreasing costs.

From Thermo Fisher Scientific Inc. 28 May 2020

Simple urine-testing method for people with kidney stones offers results in 30 minutes

An improved urine-testing system for people suffering from kidney stones inspired by nature and proposed by researchers from Penn State and Stanford University may enable patients to receive results within 30 minutes instead of the current turnaround time of a week or more.

27 May 2020

Environmental chemicals linked to changes in the gut microbiome and health

The microbes that inhabit our bodies are influenced by what we eat, drink, breathe and absorb through our skin, and most of us are chronically exposed to natural and human-made environmental contaminants.

21 May 2020

Transcranial direct current stimulation does not affect metabolism, study shows

Transcranial direct current stimulation, tDCS, is a promising treatment for conditions such as depression and addictive disorders.

12 May 2020

Novel approach could lead to more targeted search for new medicinal plants

With their rich repertoire of anti-infective substances, medicinal plants have always been key in the human fight to survive pathogens and parasites.

11 May 2020

Predicting the dose for repurposing nitazoxanide in COVID-19

A new study published on the preprint server medRxiv in May 2020 reports a model that could help evolve appropriate dosage protocols for future clinical trials of the repurposed drug nitazoxanide in COVID-19 prevention and treatment. The researchers say, “It was possible to achieve plasma and lung tizoxanide concentrations, using proven safe doses of nitazoxanide, that exceed the EC90 for SARS-CoV-2.”

7 May 2020

The Role of Microphysiological Systems for Oncology and Stem Cell Research

In this interview, Dr. Nancy Allbritton from The Allbritton Lab talks to News-Medical and Life Sciences about the revolutionary technology and techniques for the application of new technologies for oncology and stem cell research.

From Pittcon 6 May 2020

Remdesivir shows powerful activity against SARS-CoV-2 in Vitro

Remdesivir is an antiviral first developed by Gilead in 2014 as a treatment for Ebola and Marburg viruses. However, scientists explored its possibilities as a broad-spectrum drug when it proved effective against SARS-CoV and MERS-CoV, coronaviruses which were responsible for earlier outbreaks.

30 Apr 2020

Researchers discover cause for the lack of immune defense against tumors

One of the reasons why cancer develops is because regulatory cells inhibit the body's immune defense. Researchers under the helm of the Technical University of Munich have discovered a mechanism for identifying regulatory cells in tumor tissue that suppress an immune response.

29 Apr 2020

Study: Early changes in microbiome development can impact health and disease later in life

A team of researchers at Children's Hospital of Philadelphia (CHOP) has characterized how the gut microbiome develops in the first hours of infancy, providing a critical baseline for how changes in this environment can impact health and disease later in life.

17 Apr 2020