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Setting a course for the future of tissue engineering

The editors of Tissue Engineering asked 24 leaders in the field what critical steps are needed for tissue engineering to achieve broad critical success by the year 2021 and published their findings in the December 2007 issue (Volume 13, Number 12).

13 Dec 2007

Reprogrammed human adult stem cells rescue diseased muscle in mice

Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease.

13 Dec 2007

Protein fingerprinting made easy

Combining some traditional experimental methods of molecular biology with computational methods of artificial intelligence, a group of researchers from Ruder Boskovic Instititute and Faculty of Natural Sciences and Mathematics from Zagreb, Croatia, demonstrated a novel approach for producing 'protein fingerprints' of diverse tissues.

13 Dec 2007

Novel way to diagnose mantle cell lymphomas

Mantle cell lymphoma is an aggressive form of blood cancer that most commonly afflicts older men.

13 Dec 2007

More regulatory DNA than previously thought

Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off.

13 Dec 2007

Researchers advance stem cell gene therapy

Ireland Cancer Center of University Hospitals Case Medical Center researchers have recently made great strides in stem cell gene therapy research by transferring a new gene to cancer patients, via their own stem cells, with the ultimate goal of being able to use stronger chemotherapy treatment with less severe side effects.

13 Dec 2007

Immune compound blocks virus' ability to hijack antibodies

Researchers at Washington University School of Medicine in St. Louis have shown that a controversial phenomenon known as antibody-dependent enhancement (ADE) of infection is suppressed by C1q, a blood-borne immune system compound.

13 Dec 2007

Cell-tracking software speeds drug development

Time is money, especially in the race to discover new anti-inflammatory drugs and bring them to market.

13 Dec 2007

Crimean Congo hemorrhagic fever virus strips away immune system's defensive measures

When the alert goes out that a virus has invaded the body, cells that have yet to be attacked prepare by "armoring" themselves for combat, attaching specific antiviral molecules to many of their own proteins to help resist the invader.

13 Dec 2007

Secret lives of enzymes revealed

In a new study in Nature, Brandeis University Howard Hughes Medical Investigator Dr. Dorothee Kern and collaborators pull back the curtain on the secret lives of enzymes, the ubiquitous proteins that catalyze chemical reactions in the cell.

13 Dec 2007

Cancer stem cells may be cause of brain tumors

Expert available for comment on "Cancer Stem Cells" symposium at American Society of Hemotology (ASH) meeting, led by Dr. Andrew Schafer, chairman of medicine, NewYork-Presbyterian/Weill Cornell, and president, ASH.

13 Dec 2007

Extracts from fungi show potential as prostate cancer treatment

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer.

13 Dec 2007

Velcade, lenalidomide and dexamethasone combo show promise for multiple myeloma

A new combination of bortezomib (Velcade) and two other drugs is showing a very high response rate in patients newly diagnosed with multiple myeloma, a team headed by Dana-Farber Cancer Institute investigators reported at the annual meeting of the American Society of Hematology.

13 Dec 2007

Cell trafficking finding may aid drug development

With findings highlighted on a recent cover of Developmental Cell , researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.

12 Dec 2007

Sysmex America receives FDA clearance for new hematology analyzer

Sysmex America, Inc. has announced that its Sysmex XE-5000 Automated Hematology Analyzer has been cleared by the United States Food and Drug Administration (FDA) for sale in the U.S.

From Sysmex America, Inc. 12 Dec 2007

Start Licensing strengthens position in cloning industry with new patents

Start Licensing, Inc. (Start) has announced that the U.S. Patent and Trademark Office has granted U.S. Patent Nos. 7,304,204 and 7,307,198 covering methods of cloning ungulate animals, fetuses and embryos using differentiated cells.

12 Dec 2007

Scientists develop new drug to outflank cancer resistance

A new drug has shown promising results against breast and prostate cancer cells and tumours that are resistant to conventional hormone-based treatments, according to research published in the British Journal of Cancer.

12 Dec 2007

Protein-dependent "switch" regulates intracellular trafficking in epithelial cells

12 Dec 2007

Biodegradable polymers with neurotransmitters promote nerve regrowth

Research reported December 11 in the journal Advanced Materials describes a potentially promising strategy for encouraging the regeneration of damaged central nervous system cells known as neurons.

12 Dec 2007

Data confirm Dasatinib's effectiveness in resistant chronic myelogenous leukemia

Updated clinical trial results show that the drug dasatinib (Sprycel) continues to be highly effective in patients with chronic myelogenous leukemia who were unable to tolerate Gleevec or who developed resistance to it, reports a team led by researchers at Dana-Farber Cancer Institute.

12 Dec 2007