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Patient characteristics including demographic factors and comorbidities can accurately predict the outcome of COVID-19 infection severity

New machine learning models incorporating COVID-19 infection data show that patient demography is a key predictor of infection outcome.

13 Jul 2021

New approach that uses machine learning could transform drug development

Writing in the July 12, 2021 online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

12 Jul 2021

Untargeted metabolomics profiling can improve diagnosis of metabolic disorders in newborns

A team led by researchers at Baylor College of Medicine found that a screening method known as untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism, a group of rare genetic conditions, by about seven-fold when compared to the traditional metabolic screening approach.

12 Jul 2021

UCR scientists receive additional federal funding to boost research on brain injury

Earlier this year, Viji Santhakumar, an associate professor of molecular, cell and systems biology at the University of California, Riverside, received funding from the National Institute of Neurological Disaster and Stroke of the National Institutes of Health, or NIH, to further pursue research on moderate concussive brain injury.

12 Jul 2021

Groundbreaking technology offers hope for people who have lost their sense of touch

Tel Aviv University's new and groundbreaking technology inspires hope among people who have lost their sense of touch in the nerves of a limb following amputation or injury.

12 Jul 2021

Novel method of gene therapy promises to transform the treatment of rare genetic disorder

A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities.

12 Jul 2021

The progressive increase in transmissibility and virulence of emerging SARS-CoV-2 variants could lead to a significantly more deadly pandemic

Researchers from Toronto University, Canada, recently showed that these emerging VOCs were linked to increased virulence, as determined by hospitalization risk, ICU admission, and mortality. This study is currently available on the medRxiv* preprint server.

12 Jul 2021

Review of scientific evidence supports zoonotic origin for SARS-CoV-2 with zero biological evidence for laboratory leak scenario

Recently, an international team of biologists, led by professors from the University of Sydney and the University of Edinburgh, critically reviewed currently available scientific evidence that may throw some light on the origin of the virus that causes COVID-19.

12 Jul 2021

Pfizer aims to implement boosters and a new vaccine based on SARS-CoV-2 Delta variant

The drugmaker Pfizer, one of the companies behind the Pfizer-BioNTech vaccine, or BNT162b2, awaits the green light to develop a COVID-19 booster shot that can protect against emerging variants. Pfizer’s COVID-19 vaccine has been shown to be 95% effective in an ongoing large-scale clinical trial against the original SARS-CoV-2 strain.

11 Jul 2021

New Brigham–Wyss Diagnostic Accelerator could enable fast creation of diagnostic technologies

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston's Brigham and Women Hospital (Brigham) announce their newly founded Diagnostic Accelerator (Brigham-Wyss DxA).

9 Jul 2021

Scientists analyze the sensitivity of SARS-CoV-2 Delta variant to monoclonal antibodies

The Delta variant was detected for the first time in India in October 2020 and has since spread throughout the world.

9 Jul 2021

Scientists unravel mechanisms involved in epithelial integrity

To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form and connectivity.

9 Jul 2021

Mating can turn off a single gene for multiple generations, study shows

Evidence suggests that what happens in one generation--diet, toxin exposure, trauma, fear--can have lasting effects on future generations.

9 Jul 2021

Metabolites of intestinal bacteria can positively influence the efficacy of tumor therapies

Certain metabolites of bacteria from the intestine make immune cells more aggressive as a new study conducted by scientists from Würzburg and Marburg reveals. The findings could help improve cancer therapies.

9 Jul 2021

Effort to decipher hospital prices yields key finding: don’t try it at home

A federal price transparency rule that took effect this year was supposed to give patients, employers and insurers a clearer picture of the true cost of hospital care.

9 Jul 2021

SARS-CoV-2 antibody testing in oral fluids may be an efficient way forward for research in children

A recent study by researchers from the United Kingdom (UK) and Brazil shows how laboratory assays based on the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in oral fluids can be used as a suitable tool for population-based seroepidemiology studies in children. The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

8 Jul 2021

Breakthrough SARS-CoV-2 infection among fully vaccinated likely to be less transmissible

Researchers in the United States have conducted a study suggesting that individuals fully vaccinated against coronavirus disease 2019 (COVID-19) who develop breakthrough infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are less likely to transmit the virus to others than unvaccinated infected individuals.

8 Jul 2021

Scientists discover drug candidates for treating liver fibrosis among pesticides

Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals.

8 Jul 2021

Growing concern over SARS-CoV-2 Lambda variant

A new report from Chile – currently available on the medRxiv* preprint server – reveals how mutations in the spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Lambda variant can confer protection from neutralizing antibodies and increase viral infectivity rates, which means massive vaccination campaigns should be accompanied by strict genomic surveillance.

8 Jul 2021

Biomarker discovery can open door to screening newborn babies for pyridoxine-dependent epilepsy

The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease.

8 Jul 2021

Laboratory News and Research

Patient characteristics including demographic factors and comorbidities can accurately predict the outcome of COVID-19 infection severity

New approach that uses machine learning could transform drug development

Untargeted metabolomics profiling can improve diagnosis of metabolic disorders in newborns

UCR scientists receive additional federal funding to boost research on brain injury

Groundbreaking technology offers hope for people who have lost their sense of touch

Novel method of gene therapy promises to transform the treatment of rare genetic disorder

The progressive increase in transmissibility and virulence of emerging SARS-CoV-2 variants could lead to a significantly more deadly pandemic

Review of scientific evidence supports zoonotic origin for SARS-CoV-2 with zero biological evidence for laboratory leak scenario

Pfizer aims to implement boosters and a new vaccine based on SARS-CoV-2 Delta variant

New Brigham–Wyss Diagnostic Accelerator could enable fast creation of diagnostic technologies

Scientists analyze the sensitivity of SARS-CoV-2 Delta variant to monoclonal antibodies

Scientists unravel mechanisms involved in epithelial integrity

Mating can turn off a single gene for multiple generations, study shows

Metabolites of intestinal bacteria can positively influence the efficacy of tumor therapies

Effort to decipher hospital prices yields key finding: don’t try it at home

SARS-CoV-2 antibody testing in oral fluids may be an efficient way forward for research in children

Breakthrough SARS-CoV-2 infection among fully vaccinated likely to be less transmissible

Scientists discover drug candidates for treating liver fibrosis among pesticides

Growing concern over SARS-CoV-2 Lambda variant

Biomarker discovery can open door to screening newborn babies for pyridoxine-dependent epilepsy

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