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Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus.

9 Jan 2005

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Adenosine Therapeutics announced today the award of a Phase II Small Business Innovation Research (SBIR) grant from the National Institutes of Health.

6 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Smoking habits during pregnancy may cause genetic instability in the foetus

The Spanish Pediatrics Association has recently awarded the Pediatrics laboratory at the University of Navarre for a research into tobacco and foetal genetic instability.

2 Dec 2004

Novel anti-obesity compound shows promise for treatment of obesity

Arena Pharmaceuticals announced today results from the dosing phase of its Phase 1b clinical trial of APD356, an orally administered small molecule designed to regulate satiety (and perhaps metabolism) for the treatment of obesity.

30 Nov 2004

Astronaut's eyes may become windows on the bloodstream

Our eyes may become more than windows of the soul if a multidisciplinary team of University of Michigan researchers succeeds with a clever combination of nanoparticles and ultrafast pulsed laser to see individual cells as they zip past in the bloodstream.

29 Nov 2004

Study links a novel protein pathway to the aggressive progression of breast cancer

Cytogen Corporation today announced the publication of a study linking a novel protein pathway to the aggressive progression of breast cancer.

24 Nov 2004

Acetaminophen shows positive cardioprotective effects In heart attack, arrhythmia

Long an under-studied yet widely-used over-the-counter medication, acetaminophen over the last few years is becoming recognized for a range of potential therapeutic uses beyond headache and pain.

16 Nov 2004

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

Berlex announced today that new laboratory results demonstrate that its modified version of the naturally occurring lipoxin molecule exerts potent anti-inflammatory and immunomodulatory effects in Crohn's disease in vivo models and may provide a promising new oral treatment.

9 Nov 2004

Patent issued for nanotechnology bone biomaterial

Competitive Technologies announced today that patent number 6,808,561 has been issued by the US Patent Office for Dr. Brian R. Genge's nanotechnology bone biomaterial developed at the University of South Carolina (USC).

1 Nov 2004

Scientists have uncovered a significant new link in the chain of immune system events through which estrogen prevents bone loss

Through research in mice, the scientists discovered that an immune signaling molecule called type b transforming growth factor (TGFb) is responsible for a cascade of events that leads estrogen to prevent bone loss.

29 Oct 2004

Potential new protein marker for prognosis of breast and ovarian cancer

The researchers matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with a better clinical outcome in both cancer types.

24 Oct 2004

First sliver-sized sensor to monitor glucose level for diabetics and other bodily fluid levels

It's a good thing that the now eight-year-old son of Miklos Gratzl, a Case Western Reserve University biomedical engineer, got a splinter in his finger one day – at least for the sake of science. With apologies to his son – instead of an "Ouch!" moment, for Gratzl it was more of an "A-ha!" moment.

18 Oct 2004

RiboNovix secures license to novel anti-infective discovery technology from Wayne State University

New biotechnology company, RiboNovix, Inc., is addressing the worsening problem of antibiotic-resistant bacteria by developing new anti-infectives that are less susceptible to drug resistance.

5 Oct 2004

Researchers show gossypol – a drug refined from cottonseed oil is a cancer treatment booster

New research has opened up the prospect that gossypol – a drug refined from cottonseed oil and previously tried and abandoned as a male contraceptive – could boost the effectiveness of treatment for prostate tumours and possibly other common cancers as well.

30 Sep 2004

in vivo News and Research

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Smoking habits during pregnancy may cause genetic instability in the foetus

Novel anti-obesity compound shows promise for treatment of obesity

Astronaut's eyes may become windows on the bloodstream

Study links a novel protein pathway to the aggressive progression of breast cancer

Acetaminophen shows positive cardioprotective effects In heart attack, arrhythmia

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

Patent issued for nanotechnology bone biomaterial

Scientists have uncovered a significant new link in the chain of immune system events through which estrogen prevents bone loss

Potential new protein marker for prognosis of breast and ovarian cancer

First sliver-sized sensor to monitor glucose level for diabetics and other bodily fluid levels

RiboNovix secures license to novel anti-infective discovery technology from Wayne State University

Researchers show gossypol – a drug refined from cottonseed oil is a cancer treatment booster

First generation of human retinal cells in the laboratory from human embryonic stem cells

Genome researchers to look at 1918 Spanish flu

New oral gel used instead of injection to deliver drugs

Sinovac completes dosing in phase 1 human clinical testing of SARS vaccine

Phase 1 clinical trial of new anticancer drug from Human Genome Sciences

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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