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Whitehead Institute researchers identify drug target for anemia

Researchers at Whitehead Institute have identified a protein that is the target of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.

10 Jun 2013

Stem cells that strongly express WNT3 are biased to develop into cells and tissues, say researchers

According to researchers at Boston Children's Hospital, stem cells that strongly express a gene called WNT3 are biased to develop into cells and tissues including pancreas, liver and bladder.

5 Jun 2013

Restoring blood vessels may help cure type 1 diabetes, finds University of Missouri scientist

Millions of people with type 1 diabetes depend on daily insulin injections to survive. They would die without the shots because their immune system attacks the very insulin-producing cells it was designed to protect. Now, a University of Missouri scientist has discovered that this attack causes more damage than scientists realized.

30 May 2013

Adult stem cells combined with new drug could hold key to curing type 1 diabetes

29 May 2013

Single injection of human neural stem cells improves acute spinal cord injuries in rats

An international team led by researchers at the University of California, San Diego School of Medicine reports that a single injection of human neural stem cells produced neuronal regeneration and improvement of function and mobility in rats impaired by an acute spinal cord injury.

28 May 2013

Findings highlight importance of IL-21 in the development of antiviral vaccines

Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.

24 May 2013

Newly discovered immune protein has potential to stop or reverse type 1 diabetes

Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

21 May 2013

UIC researchers to study gender differences in how the heart uses and stores fat

Researchers at the University of Illinois at Chicago College of Medicine will study gender differences in how the heart uses and stores fat -- its main energy source -- and how changes in fat metabolism play a role in heart disease, under a new $2 million, 4-year grant from the National Heart, Lung and Blood Institute.

21 May 2013

Implications for manipulating immune response for some inflammatory disorders

Cytokines are molecules produced by immune cells that induce the migration of other cells to sites of infection or injury, promote the production of anti-microbial agents, and signal the production of inflammatory mediators.

14 May 2013

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

10 May 2013

Researchers discover new technique that directly converts skin cells into functional brain cells

Researchers at Case Western Reserve School of Medicine have discovered a technique that directly converts skin cells to the type of brain cells destroyed in patients with multiple sclerosis, cerebral palsy and other so-called myelin disorders.

15 Apr 2013

Researchers use miniature electronic device to tap into internal reward system of mice

Using a miniature electronic device implanted in the brain, scientists have tapped into the internal reward system of mice, prodding neurons to release dopamine, a chemical associated with pleasure.

15 Apr 2013

Research shows new separation process could help advance stem cell therapies

A new separation process that depends on an easily-distinguished physical difference in adhesive forces among cells could help expand production of stem cells generated through cell reprogramming.

8 Apr 2013

New laboratory study shows certain protein particles multiply, spread from one cell to another

In diseases like Alzheimer's and Parkinson's endogenous proteins accumulate in the brain, eventually leading to the death of nerve cells. These deposits, which consist of abnormally formed proteins, are supposed to migrate between interconnected areas of the brain, thereby contributing to the development of the illness.

28 Mar 2013

Study: Gene therapy can boost heart muscle function

In an animal study, researchers at the University of Washington show that it is possible to use gene therapy to boost heart muscle function. The finding suggests that it might be possible to use this approach to treat patients whose hearts have been weakened by heart attacks and other heart conditions.

27 Mar 2013

Two studies shed light on molecular biology of three blood disorders

Two studies led by investigators at Weill Cornell Medical College shed light on the molecular biology of three blood disorders, leading to novel strategies to treat these diseases.

26 Mar 2013

Research reveals method to produce retinal cells from regenerative human stem cells

Research led by a biology professor in the School of Science at Indiana University-Purdue University Indianapolis has uncovered a method to produce retinal cells from regenerative human stem cells without the use of animal products, proteins or other foreign substances, which historically have limited the application of stem cells to treat disease and other human developmental disorders.

20 Mar 2013

Researchers show epigenetic changes influence known genetic risk variants for type 2 diabetes

Type 2 diabetes has strong hereditary tendencies and the genes we are born with cannot be changed. However, new research from Lund University in Sweden shows that we can modify the function of the genes through the epigenetic changes that take place in the course of life.

19 Mar 2013

Researchers find white blood cells produce and eliminate RBCs

Researchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages - white blood cells that play a key role in the immune response - also help to both produce and eliminate the body's red blood cells (RBCs).

18 Mar 2013

New molecular sensor technique for cancer therapy detects lactate levels in individual cells

Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies.

16 Mar 2013