Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Bacterial metabolism of bile acids boosts generation of immune cells, study shows

A Ludwig Cancer Research study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells--immune cells that suppress autoimmune reactions and inflammation.

15 Apr 2020

Natural approaches along with current therapies could improve colon cancer treatment

Using a modified natural substance along with current approaches could improve colon cancer treatment, according to findings by University of California, Irvine biologists.

6 Apr 2020

Study investigates if the body's immune response to infections changes with seasons

Ground breaking new research is underway at the University of Surrey in collaboration with Columbia University to investigate if the body's immune response to infectious diseases and viruses, such as COVID-19, is altered by different seasons.

2 Apr 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020

Computer program analyzes blood plasma to identify weight gain biomarkers

Researchers at the University of Campinas in São Paulo State, Brazil, have developed a computer program that analyzes molecules in blood plasma to search for biomarkers that identify individuals who are at risk of becoming overweight and developing obesity-related diseases.

10 Mar 2020

Researchers find previously unknown response within gut microbiome

The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health. Recent studies have linked the gut microbiome with several beneficial properties, such as aiding in the development of our immune system and warding off pathogen infections.

5 Mar 2020

Researchers identify a gut microbe generated byproduct linked to cardiovascular disease

Cleveland Clinic researchers have identified a gut microbe generated byproduct - phenylacetylglutamine - that is linked to development of cardiovascular disease, including heart attack, stroke and death.

5 Mar 2020

How cannabis interacts with medications

A new practice guideline published in the journal CMAJ in February 2020 describes five types of drug interactions possible with the use of cannabis. Cannabis is a plant-derived drug containing the psychoactive ingredient delta-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD). These cannabinoids are broken down by the liver enzymes cytochrome P450 C(YP)34A, and CYP2CC9.

2 Mar 2020

Ulcerative colitis and a missing microbe in the gut

Ulcerative colitis is a seriously debilitating inflammatory disease of the bowel leading to crippling symptoms that can affect the quality of life severely. Researchers from Stanford University School of Medicine have found in a new study that a missing microbe could be linked to this condition. The study was published today in the latest issue of the journal Cell Host & Microbe.

25 Feb 2020

Reduced stress associated with changes in plasma metabolite profile

Reduced stress is linked to changes in the profile of plasma metabolites, a new study from the University of Eastern Finland shows.

25 Feb 2020

Relapse is common for bariatric surgery patients who quit smoking

Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation.

23 Feb 2020

Bruker announces fully validated NMR module for metabolite quantification in urine (research use only)

Bruker has announced the release of the B.I.QUANT-UR™ 1.1 module, which complies with DIN-ISO criteria for the quantification of urine metabolites by NMR.

From Bruker BioSpin - NMR, EPR and Imaging 18 Feb 2020

Fingerprint test can identify cocaine users

Cocaine is a powerful and addictive stimulant made from coca plant leaves, which is native to South America. In the past urine and saliva tests are used to detect cocaine use. Now, a new fingerprint test can detect whether people have taken the drug or just handled it.

9 Feb 2020

Genomic sequencing technique helps understand gut microbiota one cell at a time

A population of microorganisms living in our intestine, known as the gut microbiota, plays a crucial role in controlling our metabolism and reducing the risk of conditions such as obesity and diabetes.

9 Feb 2020

Scientists identify new biomarker for identifying individuals at risk of depression

Chronic pain, or inflammation, is believed to be one of the major factors in the onset of major depressive disorder.

8 Feb 2020

Experimental fingerprint test can accurately identify traces of cocaine on human skin

An experimental fingerprint detection approach can identify traces of cocaine on human skin, even after someone has washed their hands - and the test is also smart enough to tell whether an individual has actually consumed the class A drug, or simply handled it.

6 Feb 2020

Targeting the microenvironment of cancer cells to inhibit tumor growth

The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases.

5 Feb 2020

Holistic and data-driven health assessment can help achieve early disease detection

Human Longevity, Inc., an innovator in providing data-driven health intelligence and precision health to physicians and patients, announced today the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences.

27 Jan 2020

Inexpensive drug may be used to counteract treatment resistance in patients with leukemia

A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia, one of the most common forms of blood cancer.

17 Jan 2020