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Tocilizumab in COVID-19 patients on mechanical ventilation

Now, a new study by researchers from the University of Michigan and published on the online preprint server medRxiv* in June 2020 shows that the cytokine inhibitor tocilizumab could have a favorable effect on survival in the most severely infected patients who require mechanical ventilation. This needs to be confirmed by clinical trials.

7 Jun 2020

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

By combining T and B lymphocyte analysis with manufacturability heuristic, researchers from the US and Germany proposed a set of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine peptides to use in subsequent animal studies and clinical trials. Their paper is currently available on the bioRxiv preprint server.

7 Jun 2020

People suffering from rheumatoid arthritis with increased disease activity have high thrombosis risk

People suffering from rheumatoid arthritis with increased disease activity are more often affected by thrombosis.

5 Jun 2020

Kidney impairment significantly higher among hospitalized COVID-19 patients

Germany was not hit as hard by the SARS-CoV-2 pandemic as many other European countries. The reason for this is that the wave of infection reached Germany later, that the authorities were warned by the situation in Italy and Spain and at an early stage ordered a lockdown and conducted extensive testing.

5 Jun 2020

GMU researchers studying effect of cannabidiol on exosome release

Fatah Kashanchi, Professor, Laboratory of Molecular Virology, School of Systems Biology, and Lance Liotta, Co-Director, Applied Proteomics and Molecular Medicine, are working to mitigate virally driven HIV pathenogenesis in the central nervous system.

5 Jun 2020

T cells can counteract dangerous phenomenon of mosquito-borne viruses

Every year, more than 68,000 people end up with a clinical case of Japanese encephalitis. One in four of these patients will die. The mosquito-borne virus, which is most common in Southeast Asia, also causes severe neurological damage and psychiatric disorders.

5 Jun 2020

New research focuses on protein-coding gene's role in inflammatory bowel disease

A protein-coding gene associated with autoimmune diseases such as Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease, or IBD, will be the focus of new research in the School of Medicine at the University of California, Riverside.

4 Jun 2020

New technology to monitor anti-drug antibodies in MS patients may have potential for COVID-19 testing

A new study led by Queen Mary University of London has demonstrated the effectiveness of using a novel light technology to monitor the presence of anti-drug antibodies in the treatment of multiple sclerosis, which can lead to drug resistance and treatment failure.

4 Jun 2020

Intranasal delivery of MSC-EVs shows promise for treating Alzheimer's disease

In the search for a cure for Alzheimer's disease, mesenchymal stem cells and their derived extracellular vesicles (MSC-EVs) offer much promise, thanks to their protective and anti-inflammatory properties.

4 Jun 2020

Study says vitamin-magnesium combo may reduce severity of COVID-19 in seniors

The COVID-19 pandemic that began in late December 2019 has spread to over 188 countries and territories, causing over 6.5 million cases and 385,000 deaths. With no effective therapeutic COVID-19 drug or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in sight, researchers are exploring different strategies to limit its spread and mortality.

4 Jun 2020

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

Hesperos Inc., pioneers of the Human-on-a-Chip in vitro system, today announced the publication of a new peer-reviewed publication that describes how the company’s technology can be used to investigate immune responses following treatment with biological therapeutics for multi-organ systemic diseases, including cancer, infectious diseases and inflammatory disorders.

4 Jun 2020

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

AFFiRiS, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies, today announced that detailed preclinical results with its monoclonal antibody mAB C6-17 to treat Huntington's Disease were published in the peer-reviewed journal Neurobiology of Disease.

3 Jun 2020

Tumors cause disruption of the immune system throughout the body, study finds

Cancer treatment has advanced with the advent of immunotherapies that, in some cancers, can overcome tumors' ability to evade the immune system by suppressing local immune responses.

3 Jun 2020

AI can be used to expand the role of chest X-ray imaging in COVID-19 diagnosis

According to a recent report by Johns Hopkins Medicine researchers, artificial intelligence (AI) should be used to expand the role of chest X-ray imaging -- using computed tomography, or CT -- in diagnosing and assessing coronavirus infection so that it can be more than just a means of screening for signs of COVID-19 in a patient's lungs.

3 Jun 2020

Phase III clinical trial shows benefit of rituximab for pediatric Burkitt lymphoma

Results of the phase III Inter-B-NHL-ritux 2010 clinical trial reported today in the New England Journal of Medicine show 95 percent three-year survival for pediatric patients with advanced B-cell non-Hodgkin lymphoma treated with the addition of anti-cancer immunotherapy rituximab to standard chemotherapy.

3 Jun 2020

Octapharma extends support for COVID-19 study following promising preliminary data

Following positive preliminary data, Octapharma USA is extending funding for an investigator-initiated study (IIS) focused on treating the most critical patients at the heart of the coronavirus pandemic, those experiencing hypoxia and who are at the highest risk of requiring mechanical ventilation.

3 Jun 2020

Cognitive behavior therapy superior to other psychotherapies at boosting the immune system

A review of 56 randomized clinical trials finds that psychological and behavioral therapies may be effective non-drug treatments for reducing disease-causing inflammation in the body.

3 Jun 2020

ICUs become a ‘delirium factory’ for COVID patients

Doctors are fighting not only to save lives from COVID-19, but also to protect patients' brains.

3 Jun 2020

Silent hypoxia and its role in COVID-19 detection

News-Medical speaks to Dr. Albert Rizzo about silent hypoxia and how it is occurring in individuals that are suffering from COVID-19.

3 Jun 2020

Siemens receives FDA approval for SARS-CoV-2 antibody test

Siemens Healthineers has announced that the U.S. Food and Drug Administration (FDA) had issued an Emergency Use Authorization for its total antibody test to detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, including Immunoglobulin M (IgM) and Immunoglobulin G (IgG) in the blood.

3 Jun 2020

Immune System News and Research

Tocilizumab in COVID-19 patients on mechanical ventilation

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

People suffering from rheumatoid arthritis with increased disease activity have high thrombosis risk

Kidney impairment significantly higher among hospitalized COVID-19 patients

GMU researchers studying effect of cannabidiol on exosome release

T cells can counteract dangerous phenomenon of mosquito-borne viruses

New research focuses on protein-coding gene's role in inflammatory bowel disease

New technology to monitor anti-drug antibodies in MS patients may have potential for COVID-19 testing

Intranasal delivery of MSC-EVs shows promise for treating Alzheimer's disease

Study says vitamin-magnesium combo may reduce severity of COVID-19 in seniors

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

Tumors cause disruption of the immune system throughout the body, study finds

AI can be used to expand the role of chest X-ray imaging in COVID-19 diagnosis

Phase III clinical trial shows benefit of rituximab for pediatric Burkitt lymphoma

Octapharma extends support for COVID-19 study following promising preliminary data

Cognitive behavior therapy superior to other psychotherapies at boosting the immune system

ICUs become a ‘delirium factory’ for COVID patients

Silent hypoxia and its role in COVID-19 detection

Siemens receives FDA approval for SARS-CoV-2 antibody test

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