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Review of traditional treatments and novel nutritional interventions for sickle cell disease

Nutrition-related studies involving sickle cell disease (SCD) patients, particularly those in Africa.

17 Jan 2024

Fruit fly research solves human disease and fuels new cancer immunotherapy approach

Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency.

5 Jan 2024

New approach leverages macrophages to treat traumatic brain injury

Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.

3 Jan 2024

New brain imaging technique sheds light on invisible mTBIs

Researchers have created a new brain imaging method that allows mild traumatic brain injuries (mTBIs) to be diagnosed, even when existing imaging techniques like magnetic resonance imaging (MRI) don't show any structural abnormalities.

3 Jan 2024

$Lisocabtagene maraleucel: A cost-effective second-line treatment for relapsed/refractory DLBCL$

Lisocabtagene maraleucel: A cost-effective second-line treatment for relapsed/refractory DLBCL

Lisocabtagene maraleucel (liso-cel), a CAR T-cell therapy, is a cost effective second line treatment for relapsed and refractory (hard to treat) diffuse large B-cell lymphoma (r/r DLBCL), according to a study published today in Blood Advances.

28 Dec 2023

Postpartum phagocytosis of pancreatic β-cells by macrophages regulates blood glucose levels

Pancreatic beta cells (β-cells) reside in a cluster of cells in the pancreas known as the islets of Langerhans.

4 Dec 2023

IU researchers uncover novel mechanism of pathogen entry into cells

Similar to a burglar breaking a window to get into a house, Indiana University researchers have discovered a previously unknown process by which pathogens enter a cell with physical force, breaching the body's immune defenses that prevent infection.

1 Dec 2023

Study links lifestyle choices and gender to severity of fatty liver disease in workers

Study investigates the correlation between lifestyle factors, gender, inflammation, liver dysfunction, and metabolic abnormalities with fatty liver disease severity, revealing that men are at higher risk and lifestyle choices significantly impact the disease's progression.

15 Nov 2023

Engineering approach reveals surprising macrophage phenotype with best tumor-targeting ability

Macrophages, a type of white blood cell that can destroy invading pathogens, have an innate ability to infiltrate tumor cells, making them a potentially important tool in treatments that use transplanted cells to fight disease, known as cell therapy.

15 Nov 2023

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

In a JAMA Network Open study, researchers found no evidence of neuroinflammation or blood-brain barrier dysfunction in cerebrospinal fluid markers of individuals with post-COVID-19 condition and neuropsychiatric symptoms compared to controls. The study, which assessed cytokines, chemokines, and neuroinflammation markers, suggests that persistent central nervous system immune activation may not be the primary driver of neurological long COVID symptoms.

13 Nov 2023

Targeted drug may offer a new treatment option for patients with relapsed blood cancer

A new targeted drug, studied by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James), may offer a new treatment option for patients with blood cancers, including chronic lymphocytic leukemia (CLL) and Non-Hodgkin lymphoma (NHL) whose disease has stopped responding to standard treatments.

6 Nov 2023

Japanese study uncovers protective role of nasal microbiome in eosinophilic chronic rhinosinusitis

Like other countries in the world, Japan has witnessed a worrisome increase in the prevalence of chronic rhinosinusitis (CRS) over the last decade.

6 Nov 2023

$13M NIH grant funds research to rejuvenate immune system in older adults

University of Arizona Health Sciences researchers received a $13.1 million grant from the National Institute on Aging to continue studies aimed at rejuvenating the immune system of older people in order to improve health throughout the lifespan.

1 Nov 2023

Study finds health care barriers for most pet owners with HIV

People living with HIV may face hard choices when balancing their own health needs with caring for a pet, a study led by a University of Florida College of Public Health and Health Professions researcher finds.

1 Nov 2023

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

AbbVie today announced that the UK Medicines and Healthcare products Regulatory Agency has granted conditional Marketing Authorisation for Tepkinly® (epcoritamab) as a monotherapy for the treatment of adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), after two or more systemic therapies.

28 Oct 2023

How does diet impact rosacea and acne?

The associations between diet, rosacea, and acne.

19 Oct 2023

Kidney transplantation turns back the clock on renal aging

This recent study in the Journal of Internal Medicine reveals that kidney transplantation mitigates the effects of renal aging in chronic kidney disease patients, outperforming dialysis. The research utilized DNA methylation clocks to assess biological age, finding that age acceleration decreased one year post-transplant but remained unchanged with dialysis.

17 Oct 2023

Pitt scientists develop new approach to reduce side effects of organ transplants

Giving living donor liver transplant recipients an infusion of immune cells derived from their donor a week before transplantation is feasible, safe – and may lead to recipients being successfully weaned off immunosuppressant medications without rejecting the transplanted organ.

11 Oct 2023

Study supports genetic predisposition to chronic regional pain syndrome in a third of cases

Genes may be responsible for third of complex regional pain syndrome cases. But the condition is less common in men, even though they are more likely to have the 4 genetic variations implicated in heightened risk, suggesting that there may be sex specific causes, say the researchers.

10 Oct 2023

New insights into how neutrophils fight Candida albicans infection

Umeå University researchers, Sweden, unveil how the most common white blood cells, neutrophils, counter Candida albicans toxin stopping its tracks.

5 Oct 2023