Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

DBS helps anorexia patients achieve and maintain improvements in body weight, mood and anxiety

In a world first, a team of researchers at the Krembil Neuroscience Centre and the University Health Network have shown that Deep Brain Stimulation (DBS) in patients with chronic, severe and treatment-resistant Anorexia Nervosa (anorexia) helps some patients achieve and maintain improvements in body weight, mood, and anxiety.

6 Mar 2013

Misdiagnosed bipolar depression has subtle clinical features

Increased appetite, sleep, and weight gain, among other clinical features, can be used to help identify patients with bipolar disorder who have been misdiagnosed with major depressive disorder.

5 Mar 2013

Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

For the first time, scientists have discovered that five major psychiatric disorders—autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder and schizophrenia—share several common genetic risk factors.

28 Feb 2013

Patients with untreated depression are poorly protected by shingles vaccination

Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine.

16 Feb 2013

Depression reduces efficacy of shingles vaccine

Research suggests that the varicella zoster, or shingles, vaccine is less effective in older people with untreated depression.

15 Feb 2013

Nightmare of insomnia could explain suicide link in patients with depression

The link between insomnia and suicidal thoughts in patients with depression may be mediated by nightmares and dysfunctional beliefs and attitudes about sleep, research suggests.

15 Feb 2013

Physical activity may reduce risk of depression in patients undergoing bariatric surgery

Adults undergoing bariatric surgery who are more physically active are less likely to have depressive symptoms and to have recently received medication or counseling for depression or anxiety than their less active counterparts, according to new research led by the University of Pittsburgh Graduate School of Public Health.

15 Feb 2013

Targacept reports net loss of $15.9 million for fourth quarter 2012

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics, today reported its financial results for the fourth quarter and year ended December 31, 2012.

14 Feb 2013

New insights on role of placebo in depression

A randomized controlled trial published in one of the last issue of Psychotherapy and Psychosomatics unravels new insights on the role of placebo in depression.

10 Feb 2013

Weekend reading: Mental health discrimination; A doctor faces hard questions; Long-term outlook for health care jobs

"When I had cancer, I got cards and flowers," Karen Kangas' sign reads. "When I was diagnosed with bipolar disorder, I got no cards and a pink slip." A picture of Kangas holding the sign hangs in the state Capitol complex, part of an exhibit called "Discrimination: A Roadblock to Recovery."

9 Feb 2013

Top-line results from Vanda's tasimelteon Phase IIb/III study on major depressive disorder

Vanda Pharmaceuticals Inc. today announced top-line results of the Phase IIb/III clinical study (MAGELLAN) in Major Depressive Disorder (MDD), investigating the efficacy and safety of tasimelteon as a monotherapy in the treatment of patients with MDD.

31 Jan 2013

Bipolar pedigree endophenotypes found

Researchers have found cognitive endophenotypes in a single extended family showing linkage of bipolar disorder to a risk locus on chromosome 4.

30 Jan 2013

Cerebrospinal fluid IL-6 increased in schizophrenia

Cerebrospinal fluid levels of interleukin-6 are significantly increased in patients with schizophrenia and major depressive disorder, Japanese study results show.

9 Jan 2013

Postpartum depression could impact health of babies in Ghana

Postpartum depression not only affects mothers but it could mean higher health risks for the baby - especially in low-income countries like Ghana where the condition isn't well-recognized, University of Michigan Health System research shows.

9 Jan 2013

Comorbid Axis I disorders highly prevalent in mood disorder patients

More than 80% of patients with mood disorders have at least one comorbid Axis I disorder, study results show.

3 Jan 2013

Naurex announces completion of $38M Series B financing

Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today announced the completion of a $38 million Series B financing led by new investor Baxter Ventures.

17 Dec 2012

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

Takeda Global Research & Development Center, Inc., (Takeda) and H. Lundbeck A/S (Lundbeck) jointly announced today that the U.S. Food and Drug Administration (FDA) has accepted for filing their submission of a New Drug Application (NDA) for vortioxetine for the treatment of major depressive disorder (MDD) in adult patients.

13 Dec 2012