Precision Medicine News and Research

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Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

12 Sep 2022

Study reveals two distinct types of obesity with physiological and molecular differences

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

12 Sep 2022

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Results of a small, but unique research study, led by researchers from the Seaver Autism Center for Research and Treatment at Mount Sinai and published online in Human Genetics and Genomic Advances, suggest that low-dose ketamine is generally safe, well-tolerated and effective to treat clinical symptoms in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.

6 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

Tumors have significant differences depending on the person affected, even if they are the same cancer, such as breast cancer.

1 Sep 2022

SARS-CoV-2 antigen levels associated with COVID-19 severity and other clinical outcomes

The amount of SARS-CoV-2 antigen measured in the blood of patients hospitalized with COVID-19 is associated with illness severity and other clinical outcomes, according to a new study published in the Annals of Internal Medicine.

29 Aug 2022

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

Alzheimer's disease (AD) is the most common type of dementia affecting an estimated 6.3 million Americans age 65 and older. Without the development of medical breakthroughs to prevent, treat, slow or cure AD that number could grow to 13.8 million by 2060.

29 Aug 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research -; finding molecules able to target the "undruggable proteome."

29 Aug 2022

Weill Cornell Medicine laryngologist wins Paul B. Beeson Emerging Leaders Career Development Award in Aging

Dr. Anaїs Rameau, an assistant professor of otolaryngology and an attending laryngologist at the Sean Parker Institute for the Voice at Weill Cornell Medicine, has been awarded a Paul B. Beeson Emerging Leaders Career Development Award in Aging by the National Institute on Aging, the American Federation for Aging Research and the John A. Hartford Foundation.

26 Aug 2022

Functional architecture of the brain's reward system predicts appetite changes in depression

Major depressive disorders are characterized by a significant health burden, including changes in appetite and body weight.

24 Aug 2022

New discovery helps explain the dynamics underlying liver damage in type 2 diabetes and obesity

When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type 2 diabetes and obesity.

19 Aug 2022

No one-size-fits-all AI program exists for all preventive treatments

A Rutgers analysis of dozens of artificial intelligence (AI) software programs used in precision, or personalized, medicine to prevent, diagnose and treat disease found that no program exists that can be used for all treatments.

18 Aug 2022

New study advances the understanding of genetic basis of autism

A new study of genes underlying neurodevelopmental differences has uncovered more than 70 that are very strongly associated with autism and more than 250 with strong links to the condition.

18 Aug 2022

Hackensack Meridian Health becomes second in the world to implant Impella Bridge-to-Recovery heart pump

Hackensack Meridian Health, Hackensack University Medical Center cardiac surgeon Yuriy Dudiy, M.D. became the second in the world to successfully implant the Impella Bridge-to-Recovery (BTR)™ heart pump for the technology's U.S. Food and Drug Administration (FDA) early feasibility study (EFS) investigational device exemption (IDE).

17 Aug 2022

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

12 Aug 2022

OICR funding to help five research projects take the next step toward advancing cancer care

Five Ontario-based research projects will take the next step toward advancing cancer care in the province thanks to funding from the Ontario Institute for Cancer Research (OICR).

11 Aug 2022

International medical experts aim to use biomarker-based approaches to advance precision medicine

The diagnostics company SphingoTec GmbH (SphingoTec), announces that, during the 4th Scientific Symposium held near Potsdam, Germany, international medical experts discussed the latest developments in diagnostic and therapeutic innovations for advancing precision medicine in critically ill patients.

11 Aug 2022

Biological sex differences may be the reason behind higher cancer risk among men than women

Rates of most types of cancer are higher in men than in women for reasons that are unclear. Results from a recent study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, suggest that the cause may be underlying biological sex differences rather than behavioral differences related to smoking, alcohol use, diet, and other factors.

8 Aug 2022

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

The Boston-based LeDucq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

Precision Medicine News and Research

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Study reveals two distinct types of obesity with physiological and molecular differences

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

SARS-CoV-2 antigen levels associated with COVID-19 severity and other clinical outcomes

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

Weill Cornell Medicine laryngologist wins Paul B. Beeson Emerging Leaders Career Development Award in Aging

Functional architecture of the brain's reward system predicts appetite changes in depression

New discovery helps explain the dynamics underlying liver damage in type 2 diabetes and obesity

No one-size-fits-all AI program exists for all preventive treatments

New study advances the understanding of genetic basis of autism

Hackensack Meridian Health becomes second in the world to implant Impella Bridge-to-Recovery heart pump

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

OICR funding to help five research projects take the next step toward advancing cancer care

International medical experts aim to use biomarker-based approaches to advance precision medicine

Biological sex differences may be the reason behind higher cancer risk among men than women

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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