Immune System News and Research

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Newer treatment approaches may reduce risk of therapy-related hematologic cancers

While breakthrough treatments have emerged for several cancers over the last two decades, driving striking improvements in survival and other clinical outcomes, too little is known about the risk of therapy-related hematologic cancers following targeted and immunotherapeutic approaches.

29 May 2020

Using gene therapy to help the body to make its own cancer drugs

Imagine that we could instruct our bodies to make the drugs they need themselves. The gene technology that makes this possible is called mRNA therapy, which may become a major tool in the treatment of multiple diseases.

29 May 2020

New tool may predict best treatment for multiple myeloma

In 1844, multiple myeloma was first treated with a rhubarb pill and an infusion of orange peel. Since then, more than 15 drugs have earned FDA approval to treat multiple myeloma and with so many options, a major question has become what cocktail and sequence is best?

29 May 2020

Radiation and surgery do not prolong survival in newly diagnosed metastatic breast cancer

Up to now, women who present with a new diagnosis of breast cancer that is already in an advanced stage (stage IV) face an unanswered question about whether surgery and radiation to the tumor in the breast (local therapy) will prolong survival compared to the traditional treatment of systemic treatment alone.

29 May 2020

Rare deadly disease linked to coronavirus infection seen in children

Now, new evidence has shown that children with coronavirus disease (COVID-19) experience a Kawasaki-like illness, called multisystem inflammatory syndrome in children (MIS-C). The complication is akin to toxic shock syndrome, a condition that occurs due to sepsis. Though rare, the condition is life-threatening.

29 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020

Characterizing immune cells in malignant brain tumors

It is not always possible to completely remove malignant brain tumors by surgery so that further treatment is necessary.

28 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics at Peking University has successfully identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19, from convalescent plasma by high-throughput single-cell sequencing.

28 May 2020

Molecular signatures can predict outcome of sepsis patients based on their immune response

Scientists have identified molecular signatures in the immune component of the blood which indicate how patients in intensive care with sepsis, septic shock and systemic inflammatory response syndrome are likely to respond to the conditions.

28 May 2020

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

SignalChem, a global leader in cell signaling and protein engineering, has been conducting research on new coronaviruses since the outbreak of the virus.

From SignalChem Biotech Inc. 28 May 2020

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

A recent paper by researchers from China demonstrated comparable expression levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry mediators in adults and children, suggesting that previously implied difference in viral-entry associated genes is likely not responsible for milder symptoms in children. The study is currently available on the medRxiv preprint server.

27 May 2020

Novel immunotherapy targeting myeloid immune cells reduces tumor growth

Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions.

27 May 2020

A promising method for treating triple-negative breast cancer

Researchers at the University of Queensland may have found a way to improve treatment of triple-negative breast cancer.

27 May 2020

CanSino's potential coronavirus vaccine triggers immune response in clinical trial

Scientists across the globe are racing to develop a vaccine that can provide protection against coronavirus disease (COVID-19). An effective and safe vaccine would curb not only the current coronavirus pandemic but also prevent future outbreaks

27 May 2020

New strategy identified to address the underlying cause of LAD1 patients' symptoms

Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type 1 (LAD1) experience a suite of symptoms that trace back to an immune system dysfunction.

27 May 2020

What affects the case fatality rate of COVID-19? Analysis of top 50 affected countries

Ever since the beginning of the international spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease, researchers have been trying to identify the risk factors that increase the chances of infection. Now, a new study published on the preprint server medRxiv in May 2020 discusses various potential factors and reports the observed associations.

27 May 2020

Many different T cell receptors recognize SARS-CoV-2 antigenic sites

The global COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading over the world. However, not much is known about how the adaptive immune response kicks in following the viral challenge. This knowledge is crucial to predicting the efficacy of a vaccine and estimating the chances of reinfection.

26 May 2020

Montefiore and Einstein evaluate a new drug combination to fight COVID-19

Montefiore Health System Albert Einstein College of Medicine have begun the next stage of the Adaptive COVID-19 Treatment Trial (ACTT), to evaluate treatment options for people hospitalized with severe COVID-19 infection.

26 May 2020

Immune System News and Research

Newer treatment approaches may reduce risk of therapy-related hematologic cancers

Using gene therapy to help the body to make its own cancer drugs

New tool may predict best treatment for multiple myeloma

Radiation and surgery do not prolong survival in newly diagnosed metastatic breast cancer

Rare deadly disease linked to coronavirus infection seen in children

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

Characterizing immune cells in malignant brain tumors

New drug combinations could help overcome genetic immunotherapy resistance

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

Molecular signatures can predict outcome of sepsis patients based on their immune response

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

Novel immunotherapy targeting myeloid immune cells reduces tumor growth

A promising method for treating triple-negative breast cancer

CanSino's potential coronavirus vaccine triggers immune response in clinical trial

New strategy identified to address the underlying cause of LAD1 patients' symptoms

What affects the case fatality rate of COVID-19? Analysis of top 50 affected countries

Many different T cell receptors recognize SARS-CoV-2 antigenic sites

Montefiore and Einstein evaluate a new drug combination to fight COVID-19

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