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Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

7 Mar 2023

What is the impact of consuming walnuts on the dietary intake of total polyphenols?

Researchers performed secondary analyses of the Walnuts and Healthy Aging study (WAHA) data.

7 Mar 2023

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

Researchers developed a novel contraceptive 'ZB-06' a vaginal film containing a human contraceptive antibody called HC4-N that agglutinates sperm.

7 Mar 2023

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

In a recent study, researchers analyzed the occurrence of bacterial and viral infections in adults hospitalized with coronavirus disease 2019 (COVID-19) to determine the clinical and demographic features, outcomes, and microbial spectrums associated with bacterial coinfections and the prevalence of viral coinfections.

7 Mar 2023

Could smartphones be used for anemia screening?

In a recent study published in the PLOS ONE journal, researchers assessed the feasibility of smartphone facial colorimetry as an anemia screening technique.

7 Mar 2023

Interferon autoantibodies not implicated in long-COVID

Researchers assess the proportion of interferon autoantibodies in long COVID patients.

6 Mar 2023

Zoo study: SARS-CoV-2 surveillance across all mammal species

Researchers from Belgium conduct SARS-CoV-2 surveillance among all mammal species found in two zoos.

6 Mar 2023

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

6 Mar 2023

A measure of residual inflammatory risk may be a powerful predictor of future cardiovascular events

New evidence released today from a study of 31,245 patients already taking statin therapy indicates that inflammation may be a more powerful predictor of risk of future cardiovascular events-;such as heart attack and stroke -; than "bad" cholesterol.

6 Mar 2023

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Sometimes in the laboratory there are unexpected results. "Previously it had been observed that autoantibodies are common in severe Covid patients, those who end up in intensive care," says Jonathan Muri, postdoctoral fellow at the Institute for Research in Biomedicine (IRB, affiliated with the Università della Svizzera italiana) and co-author of the study.

6 Mar 2023

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

Staying awake later into the night and sleeping in on the weekends are hallmarks of adolescent behavior, however, erratic sleep patterns may have consequences for future heart health by increasing blood pressure among teens who have more abdominal fat, according to new research published today in Hypertension, an American Heart Association journal.

6 Mar 2023

How maternal obesity and gestational diabetes can impact DNA methylation in infants

A study published in the journal Cardiovascular Diabetology describes that maternal obesity and gestational diabetes can induce epigenetic remodeling in infants, potentially impacting metabolic and developmental pathways.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Giving noncritically ill patients hospitalized for COVID-19 a higher dose of blood-thinning medication than usual did not significantly reduce the combined risk of death from any cause, need for treatment in an intensive-care unit, a confirmed blood clot or a stroke at 30 days, according to the results of the FREEDOM-COVID trial presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Young people also at risk of colorectal cancer

When Nikki Lawson started to experience some pretty disruptive gastrointestinal discomfort at 35, she chalked it up to her food choices.

6 Mar 2023

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

People with the inherited heart condition hypertrophic cardiomyopathy (HCM) who exercised vigorously did not have an increased incidence of serious cardiac events during three years of follow-up compared with people who exercised moderately or were inactive, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

Wrist-worn device can accurately predict troponin-I and obstructed arteries in five minutes

An experimental wrist-worn device was found to predict troponin-I and obstructed arteries with 90% accuracy in five minutes, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Stick-on sensor alerts clinicians about heart failure complications

People with heart failure were 38% less likely to be readmitted to the hospital for heart failure complications within 90 days if they wore a stick-on sensor that alerted their clinician about fluid buildup in the lungs, according to a study presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Blood News and Research

Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

What is the impact of consuming walnuts on the dietary intake of total polyphenols?

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

Could smartphones be used for anemia screening?

Interferon autoantibodies not implicated in long-COVID

Zoo study: SARS-CoV-2 surveillance across all mammal species

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

A measure of residual inflammatory risk may be a powerful predictor of future cardiovascular events

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

How maternal obesity and gestational diabetes can impact DNA methylation in infants

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Young people also at risk of colorectal cancer

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

Wrist-worn device can accurately predict troponin-I and obstructed arteries in five minutes

Stick-on sensor alerts clinicians about heart failure complications

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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