Small Molecules News and Research

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Study uses baker's yeast to show how genes interact to influence a surprising cellular outcome

Most diseases are complex--caused by faults in multiple genes--but studying how combinations of different genetic variants affect cellular traits is challenging.

23 Oct 2019

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Huntington's disease (HD) is a fatal hereditary disease for which there is no cure. A novel study from Cedars-Sinai Medical Center, Los Angeles, using pluripotent stem cells advances understanding of how the disease develops and may help pave the way for identifying pathways for future treatments.

21 Oct 2019

Scientists unravel how left-right information is integrated to correct organ positioning

Scientists from the Instituto de Neurociencias CSIC-UMH in Alicante, Spain, under the supervision of Professor Angela Nieto, have discovered the molecular mechanism that ensures the right equilibrium needed in left-right signaling cascade during development for the correct leftward positioning of the heart.

17 Oct 2019

New blood self-collection device quickly estimates a person's exposure to radiation

A University of Arizona College of Medicine - Phoenix research team has developed a blood self-collection device to quickly estimate a person's exposure to radiation in the event of a nuclear accident or attack.

16 Oct 2019

New study finds genetic link for some forms of SIDS

A genetic link has now been found for some instances of Sudden Infant Death Syndrome, or SIDS. The new UW Medicine research study is the first to make an explainable link tracking the mechanism between a genetic anomaly and some forms of the devastating syndrome, which claims the lives of more than 3,000 infants a year.

11 Oct 2019

RNA Targeted Small Molecules: Finally Drug the “Undruggable” RNA

At a time when the previously untapped drug discovery opportunity promised within RNA opens up, the 2nd RNA- Targeted Drug Discovery Summit returns to reunite the leading minds from large pharma, innovative biotech and KOLs of academia to overcome unique discovery and development challenges associated with novel RNA targeted small molecule therapeutics and achieve their seemingly limitless potential.

From RNA-Targeted Drug Discovery Summit 30 Sep 2019

Novel nanogels could precisely deliver therapeutic treatments to cancer patients

Researchers at The University of Texas at Austin have developed new guidelines for fabricating nanoscale gel materials, or nanogels, that can deliver numerous therapeutic treatments to treat cancer in a precise manner.

27 Sep 2019

Russian researchers come up with faster method to discover antibiotics

Russian biochemists have identified a promising new class of antibiotics. Having studied over 125,000 molecules, they found that 2-pyrazol-1-yl-thiazole derivatives exhibit antibacterial properties.

26 Sep 2019

Streamlining the compound ordering process for life scientists in the US

Molport has announced its expansion into the US with the opening of MolPort Inc., which will streamline the compound ordering process for US customers.

25 Sep 2019

Researchers create first protein-engineered hydrogel

Imagine a perfectly biocompatible, protein-based drug delivery system durable enough to survive in the body for more than two weeks and capable of providing sustained medication release.

18 Sep 2019

New peptides improve memory in mice with Alzheimer’s

Alzheimer’s disease (AD) affects over 44 million people the world over. But now, neurologist Jack Jhamandas and his team have found two short peptides which, on daily injection into mice with symptoms of AD for just five weeks, led to a significant improvement.

18 Sep 2019

New AI-guided robotic platform for automation of synthetic biological molecules

A cross-disciplinary team of MIT researchers have published details of an artificial intelligence (AI) guided robotic platform for flow synthesis of small molecule organic compounds. The paper appeared in the August 9, 2019 issue of Science.

17 Sep 2019

World Alzheimer’s Day 2019: A timely reminder of urgent need for new drugs to tackle disease

As World Alzheimer’s Day 2019 approaches (21 September), with the aim this year of raising global awareness and understanding of the stigma, stereotypes and myths that surround a dementia diagnosis;

17 Sep 2019

New platform uses nanoparticles to deliver anti-cancer agent to cells

Scientists from the University of Cambridge have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent to cells.

16 Sep 2019

Developing next generation treatment to counteract opioid addiction

There are many moments in the human experience when tragedy elicits not only compassion, but inspiration. When Mike Zhang heard the story of a mother whose son died of an opioid overdose just one month after the teenager's introduction to the drug at a party, the Virginia Tech researcher wanted to help.

11 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Researchers analyze people’s initial immune response to dengue fever

Researchers have come one step closer to understanding how our immune system responds to acute dengue fever, a disease that has affected hundreds of thousands of people in Southeast Asia this summer alone.

29 Aug 2019

Researchers identify compounds that influence time to sexual maturity and lifespan

Every day, people are exposed to myriad chemicals, both natural and synthetic. Some of these compounds may affect human physical development, but testing them directly on people would be grossly unethical.

20 Aug 2019

Research reveals physiological events leading to successful enterovirus infection

Enteroviruses are one of the most common human pathogens leading to high number of acute and chronic infections worldwide.

19 Aug 2019

Powerful weapon discovered to fight antibiotic resistance in Staphylococcus aureus

Staphylococcus aureus bacteria are a major cause of serious infections that often persist despite antibiotic treatment, but scientists at the UNC School of Medicine have now discovered a way to make these bacteria much more susceptible to some common antibiotics.

14 Aug 2019