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MagnaPharm project opens up new possibilities in drug production

Polymorphs are crystalline materials that have the same chemical composition but different molecular packing. For example, diamond and graphite are both made from crystalline forms of carbon, but their physical and chemical properties vary drastically.

13 Apr 2021

Biology of single-celled organisms reveals potential treatment target for COPD

In a series of experiments that began with amoebas -- single-celled organisms that extend podlike appendages to move around -- Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment.

13 Apr 2021

Researchers investigate link between COVID-19 and increased risk of blood clot formation

People who have recovered from COVID-19, especially those with pre-existing cardiovascular conditions, may be at risk of developing blood clots due to a lingering and overactive immune response, according to a study led by Nanyang Technological University, Singapore (NTU) scientists.

13 Apr 2021

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun.

13 Apr 2021

Expanding risk assessment parameters improves prediction of waitlist mortality for liver transplants

The top priority in the field of transplantation is to ensure that donor organs are allocated to the patients with the greatest need.

13 Apr 2021

A novel method to visualize protein channels in bacteria

Almost all bacteria rely on the same emergency valves--protein channels that pop open under pressure, releasing a deluge of cell contents.

13 Apr 2021

Non-invasive neuromodulation approaches can prevent invasive surgery in Parkinson's patients

From optogenetics to sonogenetics to magnetognetics, scientists around the world are investigating new techniques to treat Parkinson's disease without the need for invasive surgery.

13 Apr 2021

ACE2 homology in laboratory and wild animals

A new preprint research paper posted to the bioRxiv server describes the conservation of an important receptor gene for the virus among several animal species that live in close contact or proximity to humans.

13 Apr 2021

Researchers identify new potential mechanism for age-related macular degeneration

Using laboratory-grown roundworms as well as human and mouse eye tissue, University of Maryland School of Medicine (UMSOM) researchers have identified a new potential mechanism for age-related macular degeneration-;the leading cause of blindness among older adults.

13 Apr 2021

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

13 Apr 2021

New technology shows encouraging results for treating osteosarcoma

A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues.

13 Apr 2021

Children less likely to spread SARS-CoV-2 than adults

A study conducted by researchers in Canada suggests that children may be less likely than adults to spread the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19).

12 Apr 2021

Real-world evidence from Israel on VOCs and SARS-CoV-2 vaccine protection

A new study by Israeli researchers tested the hypothesis that certain SARS-CoV-2 variants of concern can overcome protection conferred by Pfizer-BioNTech (BNT162b2) mRNA vaccine and found evidence of increased breakthrough rates in vaccinated individuals. The research paper is currently available on the medRxiv preprint server.

12 Apr 2021

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer.

12 Apr 2021

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

A new test that measures the quantity and quality of inactive HIV viruses in the genes of people living with HIV may eventually give researchers a better idea of what drugs work best at curing the disease.

12 Apr 2021

Commercial assays detect mRNA-1273 and BNT162b2 vaccine-induced SARS-CoV-2 antibodies in most vaccinated participants

A recent study by researchers from Canada aimed to examine the ability of commercial assays to detect vaccine-induced antibodies and recognize the vaccination response.

12 Apr 2021

Researchers unveil new SARS-CoV-2 inhibitor that targets viral immune evasion

In a recent quest for an effective antiviral compound, UK researchers have purified a specific enzyme of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known as nsp15 and optimized fluorescent biochemical endoribonuclease assays to screen a custom chemical library with over 5,000 commercial compounds. The study is currently available on the bioRxiv* preprint server.

11 Apr 2021

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

Tick-borne encephalitis is a disease just as nasty as it sounds. Once bitten by an infected tick, some people develop flu-like symptoms that resolve quietly but leave behind rampant neurological disease--brain swelling, memory loss, and cognitive decline.

9 Apr 2021

New biosealant therapy may help treat damaged cartilage tissue

A new biosealant therapy may help to stabilize injuries that cause cartilage to break down, paving the way for a future fix or - even better - begin working right away with new cells to enhance healing, according to a new animal-based study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

9 Apr 2021

Children may be less infectious in spreading SARS-CoV-2 to others

Children may not be as infectious in spreading SARS-CoV-2 to others as previously thought, according to new University of Manitoba-led research in CMAJ.

9 Apr 2021

Laboratory News and Research

MagnaPharm project opens up new possibilities in drug production

Biology of single-celled organisms reveals potential treatment target for COPD

Researchers investigate link between COVID-19 and increased risk of blood clot formation

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

Expanding risk assessment parameters improves prediction of waitlist mortality for liver transplants

A novel method to visualize protein channels in bacteria

Non-invasive neuromodulation approaches can prevent invasive surgery in Parkinson's patients

ACE2 homology in laboratory and wild animals

Researchers identify new potential mechanism for age-related macular degeneration

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

New technology shows encouraging results for treating osteosarcoma

Children less likely to spread SARS-CoV-2 than adults

Real-world evidence from Israel on VOCs and SARS-CoV-2 vaccine protection

Research may lead to a significant breakthrough in the battle against deadly brain tumors

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

Commercial assays detect mRNA-1273 and BNT162b2 vaccine-induced SARS-CoV-2 antibodies in most vaccinated participants

Researchers unveil new SARS-CoV-2 inhibitor that targets viral immune evasion

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

New biosealant therapy may help treat damaged cartilage tissue

Children may be less infectious in spreading SARS-CoV-2 to others

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