Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

New $6.2 million study seeks to define molecular linkages between aging and Parkinson's

A collaborative team between the University of Minnesota Medical School and Van Andel Institute will soon begin a $6.2 million study that seeks to define the molecular linkages between aging and Parkinson's disease -- an approach for new treatment targets not yet explored by many researchers.

21 Sep 2020

Biomarker for earlier diagnosis of neurodegenerative diseases detected in the eye

A new study led by Boston Medical Center researchers indicates a well-known biomarker that serves as a marker for earlier diagnosis of neurodegenerative diseases is now detectable in the eye.

21 Sep 2020

Novel mechanism that may confer protection against glaucoma identified

A team of researchers from LSU Health New Orleans Neuroscience Center of Excellence and the University of Copenhagen provides the first evidence that patients with ocular hypertension may exhibit superior antioxidant protection that promotes resistance to the elevated intraocular pressure associated with glaucoma.

17 Sep 2020

Study implicates new gene as driver of motor neuron diseases

Failures in a quality control system that protects protein-building fidelity in cells can lead to motor neuron degeneration and related diseases, according to a new study from an international team co-directed by Scripps Research molecular biologist Claudio Joazeiro, PhD.

16 Sep 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Drug for liver cirrhosis shows potential to treat dementia and motor neuron disease

A drug used to treat cirrhosis of the liver may be an effective treatment for a form of Dementia and motorneuron disease, scientists have discovered.

14 Sep 2020

NIH provides additional support for large scale study of Alzheimer's disease biomarkers

To meet the pressing need to better understand the prevalence, progression, and clinical impact of Alzheimer's disease among Mexican Americans, the National Institutes of Health has added funding for more biomarker measures, including positron emission tomography imaging, to the ongoing Health and Aging Brain Among Latino Elders Study.

14 Sep 2020

Researchers receive $16 million NIH grant to study link between autophagy and Alzheimer's disease

Age is the most significant risk factor for Alzheimer's disease. In the United States, approximately 1 in 10 people over the age of 65 have the disease, and the odds increase to nearly 1 in 3 for those over 85. However, the mechanisms by which aging increases risk are unknown.

9 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

A potential new way of treating Alzheimer’s Disease

In this interview, Dr. Brad. L. Heckman speaks to News-Medical about a new pathway that could potentially treat Alzheimers disease.

7 Sep 2020

Younger cycad seeds pose greater risk for toxicity, study reveals

University of Guam research has revealed that younger cycad seeds pose a greater risk for toxicity when consumed than more mature seeds, bringing the scientific community one step closer to understanding the origins of a neurodegenerative disease prevalent on Guam in World War II and closer to understanding related neurological disorders elsewhere.

31 Aug 2020

Massive cellular energy audit identifies genes that drive energy production, consumption

TK Adenosine triphosphate, or ATP, is the cellular energy currency that is as valuable to the human body as the dollar is to the US economy.

28 Aug 2020

Faulty RNA quality control system leads to haywire production of toxic proteins in FTLD/ALS

Researchers at Osaka University identify vicious cycle involving RNA exosome that accelerates disease progression in FTLD/ALS

24 Aug 2020

New book series advances the development of pharmaceutical agents for treating neurological, CNS disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders.

21 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

CZI announces $4.5 million to advance novel approaches in neurodegeneration field

Today, the Chan Zuckerberg Initiative announced $4.5 million in funding to support 30 pairs of researchers to collaborate and apply novel approaches for gaining greater insight into neurodegenerative disorders such as Alzheimer's, Parkinson's, and ALS.

19 Aug 2020

Switching off 'master regulator' may protect critical brain cells from Parkinson's-related damage

Switching off a molecular "master regulator" may protect the brain from inflammatory damage and neurodegeneration in Parkinson's disease, reports a study published today in Nature Neuroscience.

17 Aug 2020

Reelin inhibition may be effective for treating multiple sclerosis

In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease's characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.

12 Aug 2020

Purdue University startup receives NIH grant to advance Alzheimer's research

A $2 million grant from the National Institute on Aging at the National Institutes of Health to Neurodon, a Purdue University-affiliated startup, will help fast-track molecules that could improve memory and reduce Alzheimer's disease neurodegeneration.