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Combination of biology and lifestyle increases COVID-19 mortality in men

Being a man, having a lower income, having a lower level of education, not being married, and being born abroad in low- or middle-income countries - these are factors that, independent of one another, are related to an elevated risk of dying from COVID-19 in Sweden.

12 Oct 2020

Elevated plasma ACE2 activity persists months after SARS-CoV-2 infection

Recently, researchers from the University of Melbourne and Immune Therapies Group, Burnet Institute, Melbourne, reported that downregulation of cardiac ACE2 is linked to increased plasma ACE2 activity. This study is summarized in a preprint paper published in medRxiv.

11 Oct 2020

Temporal predictors of SARS-CoV-2 antibodies

Researchers in a recent paper published as a preprint on the preprint medRxiv, study the clinical factors, the laboratory assays to streamline plasma donor selection, and the durability of nAb responses in adults.

11 Oct 2020

Vaccines likely to be effective against SARS-CoV-2 D614G mutation

The emergence of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutation D614G has raised many questions, including whether it will cause the virus to become resistant to the vaccines produced against earlier versions of the virus. A new study published in the journal npj Vaccines in October 2020 shows that this may be an unfounded fear.

11 Oct 2020

Analysis of existing comorbidities and COVID-19 mortality

As the COVID-19 pandemic continues to spread, and research related to potential risk factors for COVID-19 mortality continues, it is becoming clear that individuals with underlying comorbidities have a greater risk of death from COVID-19. The exact contribution of different comorbidities is unclear, however. Now, a new study published in the journal PLOS ONE dissects this topic and may help to quantify the risk posed by specific conditions and offer help with the prognosis.

11 Oct 2020

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

In a study by researchers explored the possible mechanisms of the clotting disorder, focusing on the role of hypoxia-related activation of coagulation factors; cytokine storm, activation of neutrophils, and the release of neutrophil extracellular traps.

11 Oct 2020

New age and sex-specific model of COVID-19 transmission

Researchers at the University of Rostock in Germany have developed a model of coronavirus disease 2019 (COVID-19) transmission that considers subdivisions of age and sex to provide better insights into the impact that increased contact rates might have on the risk of infection and mortality.

11 Oct 2020

Launch of new WHO guidance on ethics and vector-borne diseases

On Wednesday 14 October, WHO will launch new guidance: Ethics & vector-borne diseases. The guidance document is a culmination of more than three years of work and will be a valuable new tool to support global efforts to prevent and control vector-borne diseases (VBDs).

9 Oct 2020

Investment in PPE for health care workers saves lives, provides substantial economic return

Providing adequate personal protective equipment (PPE) for all health care workers around the world requires an initial investment of billions of dollars, but the returns on that investment could be close to 8000% in productivity gains, according to a new study published this week in the open-access journal PLOS ONE by Nicholas Risko of the Johns Hopkins University School of Medicine and colleagues.

9 Oct 2020

Exuberant activation of immune cells in severe COVID-19 resembles lupus

In severe cases of COVID-19, Emory researchers have been observing an exuberant activation of immune cells, resembling acute flares of systemic lupus erythematosus (SLE), an autoimmune disease.

9 Oct 2020

Study examines ways to improve prone positioning for severe ARDS during COVID-19 pandemic

A new study published online in the Annals of the American Thoracic Society examines ways to increase the use of prone positioning for patients with severe acute respiratory distress syndrome (ARDS), and develops specific implementation strategies that can assist in clinicians' response to the COVID-19 pandemic.

9 Oct 2020

New study examines relationship between ethnic background and SARS-CoV-2 virus

Patients of Black ethnicity have an increased risk of requiring hospital admission for COVID-19, while patients of Asian ethnicity have an increased risk of dying in hospital from COVID-19, compared to White patients, a study has found.

9 Oct 2020

Men with lower income and education level may have elevated risk of dying from COVID-19

9 Oct 2020

Novel radioimmunotherapy proven effective in reversing resistance to lymphoma therapy

A new radioimmunotherapy has proven effective in reversing resistance to the most commonly used lymphoma drug, rituximab, according to research published in the October issue of The Journal of Nuclear Medicine.

8 Oct 2020

Certain pre-existing conditions may highly increase a patient's risk of dying from COVID-19

A large, international study of COVID-19 patients confirmed that cardiovascular disease, hypertension, diabetes, congestive heart failure, chronic kidney disease, stroke and cancer can increase a patient's risk of dying from the virus.

8 Oct 2020

Long-term exposure to urban air pollution may make COVID-19 more deadly

As the pandemic persists, COVID-19 has claimed more than 200,000 lives in the United States and damaged the public health system and economy.

8 Oct 2020

Study reveals substantial adverse outcomes in patients hospitalized with COVID-19

While older age is widely recognized as a risk factor for increased morbidity and mortality due to COVID-19, younger patients have received less attention as a population vulnerable to adverse clinical outcomes.

8 Oct 2020

High-intensity interval training benefits older people

Five years of high-intensity interval training increased quality of life, improved fitness and might very well have extended the lives of participants in the Generation 100 study.

8 Oct 2020

Pre-existing conditions can increase patient's risk of dying from COVID-19

8 Oct 2020

Study estimates lower herd immunity to SARS-CoV-2 in the U.S.

A new study shows that recognizing the differences in the population composition, connectedness and distribution, as well as inter-individual differences in immunity, susceptibility and infectivity, are crucial to estimating the herd immunity attained as a result of natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) more accurately.

8 Oct 2020