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Researchers report a heterologous vaccination strategy against IBV in Chickens

Researchers reported on the immunogenicity of a heterologous vaccine regimen against IBV, comprising prime doses of QAC-encapsulated plasmid and a booster dose of MVA.

2 Feb 2023

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

A new study reported a novel form of post-acute coronavirus disease 2019 (COVID-19) syndrome in children.

31 Jan 2023

Rapid engineering of novel SARS-CoV-2 therapeutic antibodies

Researchers assessed the influence of rapid engineering of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutic antibodies to expand the neutralization spectrum.

31 Jan 2023

Study evaluates SARS-CoV-2-specific antibody response in human milk

In a recent study published in the journal Communications Biology, researchers investigated the effect of the coronavirus disease 2019 (COVID-19) vaccine booster on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the milk of lactating women. Additionally, they explored whether the booster-induced antibody response differed from the homologous and heterologous boosting schedule of their primary vaccination.

29 Jan 2023

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

A recent study evaluates the presence of SARS-CoV-2 in children’s tonsils during the COVID-19 pandemic.

29 Jan 2023

Antiviral activity of natural flavonoids against various coronaviruses

A recent study describes the binding affinity and docking sites of several natural compounds, as well as their inhibitory activity against 3CLpro.

29 Jan 2023

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

The immunologic milieu of pregnancy has no effect on the durability of the anti-S IgG response to COVID-19 vaccination

29 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

In a recent study posted to the bioRxiv* preprint server, researchers designed two dumbbell-1 (DB-1) mutant Zika virus (ZIKV) infectious clones termed ZIKV-TL.PK and ZIKV-p.2.5’.

26 Jan 2023

Study investigates the link between lifestyle factors and risk of HPV infection

Human well-being has been linked to physical activity, diet balance, sleep quality, depression and anxiety.

25 Jan 2023

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Researchers reported that the SARS-CoV-2 Omicron XBB.1.5 variant evades neutralizing response elicited by bivalent vaccine boosters.

25 Jan 2023

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide.

24 Jan 2023

Researchers report a reduction in hospitalizations and deaths from SARS-CoV-2 infections during the Omicron variant-dominated wave in Malawi

Researchers conducted a serosurvey during the SARS-CoV-2 Omicron wave in Malawi.

23 Jan 2023

Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2

In a recent study posted to bioRxiv* preprint server, researchers in the United States identified several potent pan-coronavirus (CoV) inhibitors.

23 Jan 2023

How effective are prior SARS-CoV-2 infections and hybrid immunity against Omicron breakthrough infections?

Researchers performed a systematic review and meta-regression study to determine the breadth and duration of the protective immunity conferred by previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hybrid immunity.

20 Jan 2023

New trial evaluates Omicron BA.1–adapted BNT162b2 vaccine in older adults

Researchers reported the findings of the phase III trial evaluating the Omicron BA.1–adapted mono and bivalent BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in 55-year-old adults. These individuals had already received three 30μg doses of the BNT162b2 vaccine.

20 Jan 2023

Schizophrenia may be linked with vascular alterations in the brain, study suggests

A study conducted in Brazil and reported in an article published in Molecular Psychiatry suggests that schizophrenia may be associated with alterations in the vascularization of certain brain regions.

19 Jan 2023

Are dysregulated metabolism and inflammation contributing factors to the ongoing symptoms in long-term COVID-19 syndrome patients?

Researchers reported that dysregulation in energy metabolism and inflammation could contribute to long-term COVID-19 syndrome.

19 Jan 2023

Study shows SARS-CoV-2 exhibits differential tropism for nasal epithelial cells with age

Researchers explored the relationship between the development of goblet inflammatory cells and the age-related pathophysiology of SARS-CoV-2.

19 Jan 2023

Assay News and Research

Researchers report a heterologous vaccination strategy against IBV in Chickens

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

Rapid engineering of novel SARS-CoV-2 therapeutic antibodies

Study evaluates SARS-CoV-2-specific antibody response in human milk

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

Antiviral activity of natural flavonoids against various coronaviruses

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Protein adduction and p53 tumor suppressor inhibition

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

Study investigates the link between lifestyle factors and risk of HPV infection

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

Researchers report a reduction in hospitalizations and deaths from SARS-CoV-2 infections during the Omicron variant-dominated wave in Malawi

Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2

How effective are prior SARS-CoV-2 infections and hybrid immunity against Omicron breakthrough infections?

New trial evaluates Omicron BA.1–adapted BNT162b2 vaccine in older adults

Schizophrenia may be linked with vascular alterations in the brain, study suggests

Are dysregulated metabolism and inflammation contributing factors to the ongoing symptoms in long-term COVID-19 syndrome patients?

Study shows SARS-CoV-2 exhibits differential tropism for nasal epithelial cells with age

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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