Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Genetic link to erectile dysfunction discovered

According to a new study there may be a genetic link to erectile dysfunction. This is the first time that such as connection has been made and this could mean that newer avenues of treatment could be explored for erectile dysfunction, explain the researchers.

8 Oct 2018

Study highlights opposite effects of gene following different types of environmental events

Researchers have discovered that the same gene which increases your risk of depression following financial stress as you grow older also reduces your chance of depression associated with friendship and relationships stresses when young- your social network.

8 Oct 2018

Research reveals how critical oocyte quality control process works

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal life.

28 Sep 2018

DFG establishes nine new Research Units

The Deutsche Forschungsgemeinschaft is establishing nine new Research Units, following a decision by the Senate and the Joint Committee in Bonn.

25 Sep 2018

New research suggests power of zebrafish as tool for cancer drug discovery

The lab of Leonard Zon, MD, at Boston Children's Hospital has long been interested in making blood stem cells in quantity for therapeutic purposes.

24 Sep 2018

First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute

A Puerto Rican patient with X-linked retinitis pigmentosa (XLRP) is hoping to save his vision after an innovative gene therapy procedure at Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine.

19 Sep 2018

New framework combines three existing methods to find cancer cell mutations

Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results.

10 Sep 2018

Family genetic background essential for understanding autism progression

Whether an individual develops a neurodevelopmental disorder like autism or ADHD and the severity of that disorder depends on genetic changes beyond a single supposedly disease-causing mutation.

7 Sep 2018

Researchers describe novel mechanism that links epigenetic change to translational control

Understanding how memories form and are retrieved has applications to psychiatric, neurological and neurodegenerative disorders, and may be helpful to attenuate maladaptive memories in psychiatric disorders.

7 Sep 2018

Study links spinal muscular atrophy disease expression with haplotypes

A natural history study has provided the first comprehensive clinical description of spinal muscular atrophy within the Amish and Mennonite communities and correlates ancestral chromosome 5 haplotypes and SMN2 copy number with disease severity.

7 Sep 2018

Short telomeres could be independent risk factor for age-related functional decline

Elderly people with short chromosome caps, or telomeres, are more likely to have difficulty performing daily activities such as carrying groceries, climbing stairs and walking, finds a new study of more than 1,200 people from five European countries.

6 Sep 2018

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology in Italy have uncovered a previously unknown function of the DDX11 helicase enzyme.

3 Sep 2018

Novel method using big data tools shows promising routes for research

A group of researchers affiliated to the University of São Paulo - campus Ribeirão Preto, Brazil, used big data tools such as data mining and network analysis to develop a method to help scientists and companies identify technological routes, trends and partnerships in any knowledge area. For this purpose, it collected information from patent databases around the world.

3 Sep 2018

Subcutaneous injection of new protein helps treat hemophilia more effectively

Patients with hemophilia bleed spontaneously or following trauma. The most common sites of bleeding are into joints, but bleeds can also happen into any tissue in the body including the muscles, brain, or eyes.

31 Aug 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

FDA accepts Bristol-Myers Squibb’s application for Sprycel for treating pediatric leukemia

Bristol-Myers Squibb Company today announced that the U.S. Food and Drug Administration accepted its supplemental Biologics License Application for Sprycel (dasatinib) in combination with chemotherapy for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.

30 Aug 2018

Scientists explore DNA replication errors that can lead to cancer

Scientists at Hollings Cancer Center at the Medical University of South Carolina have found that some cells can divide without a molecule that was previously thought necessary.

30 Aug 2018

Researchers develop 3D map of the human genome

Researchers have developed a way of mapping the positions of genes within cells to understand more about how the genome is organized.

28 Aug 2018

Study reveals how gene variant affects chronic pain outcomes after trauma

The gene FKBP5 is a critical regulator of the stress response and affects how we respond to environmental stimuli. Previous studies have shown that certain variants of this gene play a role in the development of neuropsychiatric disorders such as posttraumatic stress disorder, depression, suicide risk, and aggressive behavior.

28 Aug 2018

Researchers uncover how RNA regulates genes during critical stage in embryonic brain development

Scientists at the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues discovered how a type of RNA, called Evf2 enhancer RNA, regulates key genes during a critical stage in embryonic brain development.

24 Aug 2018

Chromosome 4 News and Research

Further Reading

Genetic link to erectile dysfunction discovered

Study highlights opposite effects of gene following different types of environmental events

Research reveals how critical oocyte quality control process works

DFG establishes nine new Research Units

New research suggests power of zebrafish as tool for cancer drug discovery

First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute

New framework combines three existing methods to find cancer cell mutations

Family genetic background essential for understanding autism progression

Researchers describe novel mechanism that links epigenetic change to translational control

Study links spinal muscular atrophy disease expression with haplotypes

Short telomeres could be independent risk factor for age-related functional decline

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

Novel method using big data tools shows promising routes for research

Subcutaneous injection of new protein helps treat hemophilia more effectively

Muscle dystrophy treatment in dogs with Crispr gene editing

FDA accepts Bristol-Myers Squibb’s application for Sprycel for treating pediatric leukemia

Scientists explore DNA replication errors that can lead to cancer

Researchers develop 3D map of the human genome

Study reveals how gene variant affects chronic pain outcomes after trauma

Researchers uncover how RNA regulates genes during critical stage in embryonic brain development

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