Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

UIC focuses on developing an antiviral therapy for filoviruses

Researchers at the University of Illinois Chicago are working with the National Institutes of Health and researchers from across the country to establish a center for antiviral drug development for pandemic-level viruses, including Ebola and SARS-CoV-2, the virus that causes COVID-19.

11 Aug 2022

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Chemists from Scripps Research and the University of California, Los Angeles, have developed methods for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes, which are commonly used to build drug molecules.

9 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

Novel algorithm provides rich, detailed information on protein location and function within a cell

Humans are good at looking at images and finding patterns or making comparisons. Look at a collection of dog photos, for example, and you can sort them by color, by ear size, by face shape, and so on. But could you compare them quantitatively? And perhaps more intriguingly, could a machine extract meaningful information from images that humans can't?

2 Aug 2022

Timothy Huang receives $2.8 million to continue research on Alzheimer's disease

Timothy Huang, Ph.D., has been awarded $2.8 million by the National Institute on Aging (NIA) to continue his work on Alzheimer's disease.

2 Aug 2022

How does COVID-19 affect sexual and bladder functions in men?

Researchers discuss the impact of COVID-19 on the urogenital health of males.

1 Aug 2022

ALZ-NET: First data collection and sharing network for new FDA-approved Alzheimer's treatments

ALZ-NET is the first network developed specifically for new FDA-approved Alzheimer's treatments, collecting real-world evidence on drug effectiveness and side effects over a long period of time.

1 Aug 2022

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Researchers assessed the potential of nanosponges against SARS-CoV-2.

1 Aug 2022

Researchers use a tumor organoid system to examine bacterial effects on immunotherapy

Wake Forest Institute for Regenerative Medicine researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don't respond or develop a resistance to the treatment over time.

29 Jul 2022

Study uncovers the crucial roles of kinesins during the malaria parasite life cycle

Scientists at the University of Nottingham have made a major breakthrough in understanding how malaria parasites divide and transmit the disease, which could be a major step forwards in helping to prevent one of the biggest killer infections in the world.

29 Jul 2022

New breakthrough shows antimicrobial resistance is more evolved than previously recognized

Researchers have discovered a significant and previously unknown mechanism that many bacteria use to resist antibiotics.

29 Jul 2022

Scientists discover a new set of chemical reactions to generate amino acids and nucleic acids

Four billion years ago, the Earth looked very different than it does today, devoid of life and covered by a vast ocean. Over the course of millions of years, in that primordial soup, life emerged. Researchers have long theorized how molecules came together to spark this transition.

28 Jul 2022

New method for organoid production could help advance research studies

As the idea of growing tiny human organs in lab dishes has moved in recent years from futuristic science fiction to actual bioscientific reality, the usefulness of organoids as a research tool for studying the digestive system swiftly encountered a bottleneck-;these valuable tissues are quite difficult to make.

28 Jul 2022

Novel targeted therapy may be an effective treatment option for neuroblastoma

New research from VCU Massey Cancer Center -; published Thursday in Cell Reports -; demonstrated that a novel targeted therapy could be an effective treatment option for a deadly pediatric cancer known as neuroblastoma.

28 Jul 2022

A pair of analyses reveals early epicenter of the COVID-19 pandemic

The COVID-19-causing coronavirus, SARS-CoV-2, likely first spread to humans from animals in two separate transmission events in a Wuhan market in late November 2019, according to a pair of analyses by international teams co-led by Scripps Research scientists.

26 Jul 2022

Drug Discovery News and Research

Further Reading

UIC focuses on developing an antiviral therapy for filoviruses

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Novel algorithm provides rich, detailed information on protein location and function within a cell

Timothy Huang receives $2.8 million to continue research on Alzheimer's disease

How does COVID-19 affect sexual and bladder functions in men?

ALZ-NET: First data collection and sharing network for new FDA-approved Alzheimer's treatments

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Researchers use a tumor organoid system to examine bacterial effects on immunotherapy

Study uncovers the crucial roles of kinesins during the malaria parasite life cycle

New breakthrough shows antimicrobial resistance is more evolved than previously recognized

Scientists discover a new set of chemical reactions to generate amino acids and nucleic acids

New method for organoid production could help advance research studies

Novel targeted therapy may be an effective treatment option for neuroblastoma

A pair of analyses reveals early epicenter of the COVID-19 pandemic

Stopping 'budding' viruses in their tracks

CN Bio opens new laboratory facilities to extend Organ-on-a-chip contract research services capabilities

Scientists develop an improved pharmaceutical drug for the treatment of atrial fibrillation

Texas Biomed professor to join $577 million effort for developing antivirals against COVID-19 and other viruses

The Mark Foundation for Cancer Research announces latest ASPIRE awards for eight outstanding projects

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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