Transplant News and Research

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Insight into the future of genetic testing

In this interview, we speak to Sheetal Parmar, vice president of medical affairs and head of clinical services at Natera, about their cell-free DNA (cfDNA) testing services.

From Natera 15 Apr 2022

Additional booster doses of COVID-19 vaccine help protect solid organ transplant recipients

Additional booster doses of vaccine against COVID-19 are particularly important for those who are immunosuppressed, namely those who have had solid organ transplants, a new study shows.

13 Apr 2022

International study offers insight into occurrence of acute myocarditis during COVID-19 hospitalization

Acute myocarditis, inflammation of the heart muscle typically triggered by a virus, occurred in about two out of every 1,000 people hospitalized with COVID-19, and was associated with more severe illness and complications in people with COVID-19, especially among people who also had pneumonia, according to new research published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

11 Apr 2022

NK cells combined with bispecific antibody achieve effective responses in patients with lymphoma

Researchers from The University of Texas MD Anderson Cancer Center showed that natural killer (NK) cells derived from donated umbilical cord blood, combined with a novel bispecific antibody known as AFM13 that targets CD16A and CD30, achieved effective responses in patients with pretreated and refractory CD30+ lymphoma.

11 Apr 2022

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

A recent study posted to the medRxiv* preprint server assessed the impact of sotrovimab treatment on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-infected immunocompromised (IC) patients.

11 Apr 2022

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Cancer risk and related mortality significantly higher among patients with kidney disease

Patients with kidney disease may have an increased risk of cancer and may be more likely to die from cancer.

8 Apr 2022

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

Researchers described a case of co-infection with SARS-CoV-2 variants of concern, Delta and Omicron.

8 Apr 2022

A shortfall of ECMO treatment cost lives during the delta surge

Speaking from his hospital bed at Vanderbilt University Medical Center in Nashville, Tennessee, James Perkinson’s voice was raspy. In February, he’d just been taken off ECMO, the last-ditch life support treatment in which a machine outside the body does the work of the heart and lungs.

7 Apr 2022

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.

2 Apr 2022

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

Zinc's immune-boosting properties are well-established, but scientists haven't known exactly how it works.

1 Apr 2022

10-second videos of white blood cell motion improve the prediction of blood cancer relapse

In a new study from Vanderbilt University Medical Center, 10-second videos of white blood cell motion in the skin's microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

29 Mar 2022

Evaluating serological responses to repeated COVID-19 vaccination in kidney transplant recipients

Researchers analyzed whether repeated vaccinations against COVID-19 increase serological response in non-responding kidney transplant recipients.

29 Mar 2022

New technology could replace conventional biopsies and histology with real-time imaging

MediSCAPE, a high-speed 3D microscope designed by Columbia Engineers, can see real-time cellular detail in living tissues to guide surgery, speed up tissue analyses, and improve treatments.

28 Mar 2022

Climate change may push the US toward the ‘goldilocks zone’ for West Nile virus

Michael Keasling of Lakewood, Colorado, was an electrician who loved big trucks, fast cars, and Harley-Davidsons. He'd struggled with diabetes since he was a teenager, needing a kidney transplant from his sister to stay alive.

28 Mar 2022

Exploring the vital connection between gut microbes, physical activity, and health

Our bowels accommodate billions of active microbes that affect the health, a fact that is arousing increasing interest also among athletes.

26 Mar 2022

Evusheld™ found to poorly neutralize Omicron in kidney transplant patients

Researchers evaluated the neutralizing antibody titers and anti-receptor-binding domain immunoglobulin G titers in sera of kidney transplant recipients who were vaccinated against COVID-19 and treated with 300 mg dosage of Evusheld™

25 Mar 2022

New pancreatic islet cryopreservation protocol could pave the way for diabetes cure

Engineering and medical researchers at the University of Minnesota Twin Cities and Mayo Clinic have developed a new process for successfully storing specialized pancreatic islet cells at very low temperatures and rewarming them, enabling the potential for on-demand islet transplantation.

24 Mar 2022

T-cell and neutralizing antibody response after a third COVID-19 vaccine dose in hemodialysis patients

Researchers compare the impact of a third mRNA COVID-19 vaccine in hemodialysis patients by measuring antibody levels and IFN-γ responses.

23 Mar 2022

Transplant News and Research

Insight into the future of genetic testing

Additional booster doses of COVID-19 vaccine help protect solid organ transplant recipients

International study offers insight into occurrence of acute myocarditis during COVID-19 hospitalization

NK cells combined with bispecific antibody achieve effective responses in patients with lymphoma

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Cancer risk and related mortality significantly higher among patients with kidney disease

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

A shortfall of ECMO treatment cost lives during the delta surge

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

10-second videos of white blood cell motion improve the prediction of blood cancer relapse

Evaluating serological responses to repeated COVID-19 vaccination in kidney transplant recipients

New technology could replace conventional biopsies and histology with real-time imaging

Climate change may push the US toward the ‘goldilocks zone’ for West Nile virus

Exploring the vital connection between gut microbes, physical activity, and health

Evusheld™ found to poorly neutralize Omicron in kidney transplant patients

New pancreatic islet cryopreservation protocol could pave the way for diabetes cure

T-cell and neutralizing antibody response after a third COVID-19 vaccine dose in hemodialysis patients

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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