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New oral test for HIV approved by FDA

FDA today approved the use of oral fluid samples with a rapid HIV diagnostic test kit that provides screening results with over 99 percent accuracy in as little as 20 minutes. Until now, all rapid HIV tests required the use of blood in order to get such rapid results.

27 Mar 2004

St. John’s wort may interfere with cancer-fighting drug’s ability to prevent relapse in leukemia patients

St. John’s wort, an herb thought to be a safe, natural remedy for mild depression, may interfere with a powerful cancer-fighting drug’s ability to prevent relapse in leukemia patients, a University of Florida pharmacy researcher will report March 27 at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics.

26 Mar 2004

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts, according to researchers at the Technion-Israel Institute of Technology.

26 Mar 2004

Researchers have successfully grafted human breast tissue into the mammary glands of mice

The last few years have witnessed critical advances in breast cancer therapies. Still, the disease afflicts one in eight American women, and scientists have yet to develop a living model with which they can study the intricacies of human breast-tumor behavior.

26 Mar 2004

Oral chemotherapy agent Orathecin™ (rubitecan) capsules accepted by FDA for filing

SuperGen Inc. announced today that the Food and Drug Administration (FDA) has officially accepted the Orathecin™ (rubitecan) capsules’ New Drug Application (NDA) for filing. Orathecin, an investigational anticancer compound, is an oral chemotherapy agent that has been investigated as a treatment for pancreatic cancer patients who have failed at least one prior chemotherapy.

26 Mar 2004

Oral medication for diabetes a step closer

University of Toronto researchers have shown that "designer molecules" can interact with the body's insulin receptor, a step toward the development of an oral medication for diabetes. U of T professors Lakshmi Kotra, Cecil Yip, Peter Ottensmeyer and Robert Batey have created the first small molecules using the three-dimensional structure of the insulin receptor. A receptor is the site on the surface of a cell to which molecules with specific tasks, such as hormones, attach themselves. Insulin's task is to initiate the utilization of sugar in the blood.

26 Mar 2004

Bionomics files novel angiogenesis genes patent

Bionomics Limited has announced that it had filed a further international patent application that covers 496 proprietary angiogenesis drug targets. The international patent application applies to genes that Bionomics has identified using advanced technologies such as microarray and bioinformatics analyses. These technologies have enabled Bionomics to identify novel angiogenesis genes that have not been identified by other companies or research groups.

26 Mar 2004

Growth factor protein succeeds in growing new coronary arteries

Three patients of the UC Heart & Vascular Center have grown new coronary artery branches to increase blood flow to the heart after receiving a new growth factor protein (FGF1) in November 2003. All three patients showed improved blood flow to the heart twelve weeks following the injection.

26 Mar 2004

Super glue and vascular graft surgery

Got a broken teacup, an art project, or a leaky blood vessel? “Super glue” it. Surgeons at Baylor College of Medicine in Houston are studying whether a liquid sealant, similar to common household “super glue,” forms a tight seal around blood vessels used in vascular graft surgery.

25 Mar 2004

Thyroid disorders are often misdiagnosed

Thyroid disorders are among the most common medical conditions. However, because their symptoms often appear gradually, the condition is often misdiagnosed, according to Dr. Nila Vora, a board-certified endocrinologist at the Loyola Primary Care Center in Darien.

25 Mar 2004

Children with sickle cell disease are living longer, dying less often from their disease

Children with sickle cell disease, an inherited red blood-cell disorder, are living longer, dying less often from their disease and contracting fewer fatal infections than ever before, researchers at UT Southwestern Medical Center at Dallas report. Their study, which will appear in the June edition of the scientific journal Blood, is the first to evaluate survival rates of children receiving the most modern treatments for sickle cell disease. It's also one of the largest published sickle cell studies to date. Researchers followed more than 700 Dallas-area children with the disease over two decades.

25 Mar 2004

Stenting for Stroke Prevention is More Effective Than Surgery in Keeping Blood Vessels Open

Research presented in a six-hour symposium on carotid artery disease at the 29th Annual Scientific Meeting of the Society of Interventional Radiology showed carotid artery stenting to be safe and effective for highrisk patients. Currently, the standard of care for stroke prevention in patients with moderate to severely blocked carotid arteries is carotid endarterectomy surgery. The ARCHeR trials treated patients who were high-risk surgical candidates with carotid artery stenting with and without embolic protection, a device to capture debris that may break off during the procedure.

25 Mar 2004

New Research Information on Tumor Necrosis Therapy

Researchers for Peregrine Pharmaceuticals presented today at the Strategic Research Institute’s Clinical-Stage Product Partnering Summit in La Jolla, CA a summary of clinical experience with Tumor Necrosis Therapy (TNT). The TNT technology is being developed in the U.S. and Europe by Peregrine under the trade name Cotara™. Over 200 patients have been treated with TNT world-wide and a TNT product has been approved to treat grade III or IV advanced lung cancer in the People’s Republic of China. A Cotara registration study for brain cancer has been approved by the U.S. Food and Drug Administration, and a Phase I colorectal cancer study is on-going at Stanford University Medical Center.

25 Mar 2004

Approval for FOSRENOL (lanthanum carbonate), which controls phosphate levels in renal dialysis patients

Sweden's MPA has today granted the first regulatory approval in the world for FOSRENOL (lanthanum carbonate), a non-calcium, non-aluminium phosphate binding medicine developed to control phosphate levels in renal dialysis patients. Sweden will now become the Reference Member State in the EU Mutual Recognition Procedure for FOSRENOL, and this is the first step in securing marketing approval throughout Europe. A submission has also been made by Shire to gain marketing approval for FOSRENOL in the United States.

25 Mar 2004

Breakthrough studies that could lead to a new means of combating malaria

EMBL scientists have identified four mosquito proteins that affect the ability of the malaria parasite (Plasmodium) to survive and develop in the malaria-carrier mosquito (Anopheles). This breakthrough could be used to block the transmission of malaria from mosquitoes to humans.

25 Mar 2004

First US Tests of Bird-Flu Vaccine in Humans

Doctors are beginning the first test in the United States of a vaccine designed to protect people against one form of bird flu should an outbreak of the virus occur in humans. While the vaccine under study is not designed to protect against the precise bird-flu virus causing the current outbreak in poultry and in people, scientists will learn whether it protects against another strain of the virus that infects birds and people.

24 Mar 2004

Bone marrow stem cells do not help regenerate heart muscle tissue, UW study finds, contradicting earlier study

Researchers at the University of Washington School of Medicine have found that bone marrow stem cells do not convert into heart muscle cells in mice. These results contradict a study conducted elsewhere that had prompted human clinical trials for such stem cell therapy in the treatment of heart attack.

23 Mar 2004

Ban Chlorpyrifos and Diazinonon Impacts Child Birth Weights

A federal ban on two insecticides has resulted in a significant reduction in their impact on newborns' birth weight and length, according to a new study funded by the National Institute of Environmental Health Sciences of the National Institutes of Health, the U.S. Environmental Protection Agency, and other private foundations.

23 Mar 2004

New Cell Sorter Helps Understand Deadly Diseases

Researchers at NC State’s College of Veterinary Medicine have a new state-of-the-art tool, a high-speed cell sorter, that should quicken the pace of their research. The machine sorts or collates cells into groups, allowing scientists to look only at the cells they are working on.

23 Mar 2004

Cladribine Targeted to Become First Oral Therapy for Multiple Sclerosis

Serono and IVAX Corporation has announced positive results from two clinical trials with a new proprietary oral formulation of cladribine, a potential new treatment for multiple sclerosis (MS). The study results showed that the formulation of oral cladribine which has been developed by Serono and IVAX has met the targets for an orally administered product, with blood levels of cladribine in the expected therapeutic range. Efficacy studies of oral cladribine in MS patients are planned to start late 2004.

23 Mar 2004

Blood News and Research

New oral test for HIV approved by FDA

St. John’s wort may interfere with cancer-fighting drug’s ability to prevent relapse in leukemia patients

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

Researchers have successfully grafted human breast tissue into the mammary glands of mice

Oral chemotherapy agent Orathecin™ (rubitecan) capsules accepted by FDA for filing

Oral medication for diabetes a step closer

Bionomics files novel angiogenesis genes patent

Growth factor protein succeeds in growing new coronary arteries

Super glue and vascular graft surgery

Thyroid disorders are often misdiagnosed

Children with sickle cell disease are living longer, dying less often from their disease

Stenting for Stroke Prevention is More Effective Than Surgery in Keeping Blood Vessels Open

New Research Information on Tumor Necrosis Therapy

Approval for FOSRENOL (lanthanum carbonate), which controls phosphate levels in renal dialysis patients

Breakthrough studies that could lead to a new means of combating malaria

First US Tests of Bird-Flu Vaccine in Humans

Bone marrow stem cells do not help regenerate heart muscle tissue, UW study finds, contradicting earlier study

Ban Chlorpyrifos and Diazinonon Impacts Child Birth Weights

New Cell Sorter Helps Understand Deadly Diseases

Cladribine Targeted to Become First Oral Therapy for Multiple Sclerosis

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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