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Researchers identify gene variants linked to both type 2 diabetes and CHD risk

Type 2 diabetes (T2D) has become a global epidemic affecting more than 380 million people worldwide; yet there are knowledge gaps in understanding the etiology of type-2 diabetes.

4 Sep 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Whenever an organism is damaged, the cells surrounding the wound receive signals to proliferate more intensely so as to regenerate the injured tissue.

26 Aug 2017

Mayo Clinic researchers discover new cause of treatment resistance in prostate cancer

Mayo Clinic researchers have identified a new cause of treatment resistance in prostate cancer. Their discovery also suggests ways to improve prostate cancer therapy. The findings appear in Nature Medicine.

14 Aug 2017

Study provides promising framework to anticipate drug resistance in cancer

Being able to predict the resistance or sensitivity of a tumor cell to a drug is a key success-factor of cancer precision therapy.

14 Aug 2017

Counteracting premature aging

Aging is the continuing process of such stress exposures, and with advancing age (normal aging), we must carry lots of senescent cells within our bodies. Senescent cells also often provide some ‘bad influences’ to surrounding healthy cells; such as chronic inflammation and tumorigenesis

14 Aug 2017

Researchers demonstrate potential of new PET tracer for imaging prostate cancer

In the featured translational article in the August issue of The Journal of Nuclear Medicine, researchers at the University of Michigan demonstrate the potential of a new PET tracer, Carbon-11 labeled sarcosine (11C-sarcosine), for imaging prostate cancer, and set the stage for its possible use in monitoring other cancers.

7 Aug 2017

Low vitamin D may affect recovery of injured corneas

Injury or disease in combination with too little vitamin D can be bad for the window to your eyes. The three-layer, transparent cornea at the front of the eyes focuses the light coming in. But its prominent position also puts it at risk for injury from an errant mascara wand or over-prodding finger or a car accident.

24 Jul 2017

Testing treatments using pig model may help minimize drug failure rates for chronic conditions

Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of researchers.

21 Jul 2017

Scientists reveal key role of TLK2 gene in placenta development, embryo viability in mice

The placenta, a transient organ that links the developing embryo to its mother, is responsible for nutrient, waste and gas exchange between the fetus and the mother.

17 Jul 2017

Researchers discover potential substitutes for BPA that lack adverse effects

Researchers at Baylor College of Medicine have identified a group of potential substitutes for bisphenol A (BPA) that lack the adverse effects typically associated with BPA.

14 Jul 2017

New marker may help diagnose late-stage lung cancer

Investigators have found a new marker that might be used for diagnosing a common form of lung cancer, especially at late stages.

10 Jul 2017

High-throughput screening technique reveals new brain cancer drug targets

Researchers from Case Western Reserve University School of Medicine and The Cleveland Clinic designed a way to screen brain tumor cells and identify potential drug targets missed by other methods.

5 Jul 2017

Novel micro-cubes can efficiently deliver hydrophobic anti-tumor drug to cancer cells

Many potent anti-cancer drugs have major drawbacks -- they fail to mix with water, which means they will have a limited solubility in blood, and they lack selectivity to cancer cells.

29 Jun 2017

Discovery of T cell exhaustion offers new pathway to more powerful immunotherapies

St. Jude Children's Research Hospital immunologists have discovered how immune cells called T cells become "exhausted" -- unable to do their jobs of attacking invaders such as cancer cells or viruses.

28 Jun 2017

Mouse brain models reveal insights into genetics of autism

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels of disability.

28 Jun 2017

Could the mTOR pathway be used to protect against cancer?

The mTOR pathway is probably the main pathway in humans and other animals that drives growth. That is, the accumulation of mass and adding mass to make an organism bigger by both making more cells, and making cells grow and become bigger.

22 Jun 2017

MIT biologists identify how the immune system eliminates genetically imbalanced cells

Most living cells have a defined number of chromosomes: Human cells, for example, have 23 pairs. As cells divide, they can make errors that lead to a gain or loss of chromosomes, which is usually very harmful.

20 Jun 2017

Scientists design bioactive nanomaterial that excels at stimulating bone regeneration

There hasn't been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.

19 Jun 2017

Researchers discover connection between processes that keep the heart from repairing itself

Heart muscle is one of the least renewable tissues in the body, which is one of the reasons that heart disease is the leading cause of death for both men and women in the United States, according to the Centers for Disease Control and Prevention.

5 Jun 2017

Cell Proliferation News and Research

Researchers identify gene variants linked to both type 2 diabetes and CHD risk

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Mayo Clinic researchers discover new cause of treatment resistance in prostate cancer

Study provides promising framework to anticipate drug resistance in cancer

Counteracting premature aging

Researchers demonstrate potential of new PET tracer for imaging prostate cancer

Low vitamin D may affect recovery of injured corneas

Testing treatments using pig model may help minimize drug failure rates for chronic conditions

Scientists reveal key role of TLK2 gene in placenta development, embryo viability in mice

Researchers discover potential substitutes for BPA that lack adverse effects

New marker may help diagnose late-stage lung cancer

High-throughput screening technique reveals new brain cancer drug targets

Novel micro-cubes can efficiently deliver hydrophobic anti-tumor drug to cancer cells

Discovery of T cell exhaustion offers new pathway to more powerful immunotherapies

Mouse brain models reveal insights into genetics of autism

Could the mTOR pathway be used to protect against cancer?

MIT biologists identify how the immune system eliminates genetically imbalanced cells

Scientists design bioactive nanomaterial that excels at stimulating bone regeneration

Researchers discover connection between processes that keep the heart from repairing itself

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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