Small Molecules News and Research

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New findings could benefit patients with triple-negative breast cancer

About 15 percent of breast cancers are classified as triple-negative, lacking receptors for estrogen, progesterone, and Her2.

12 Oct 2018

Using pulsed electric fields in cancer therapy

Pulsed electric fields are helping fight cancer, whether by inducing tumor cell death or by stimulating the immune system.

11 Oct 2018

How Does Amyloid Formation Impact Neurodegenerative Disease?

An interview with Dr Rosie Staniforth discussing her research into amyloid formation and its impact on neurodegenerative diseases.

From Postnova Analytics 11 Oct 2018

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Carnegie's Department of Embryology scientist Steven Farber and team have been awarded a 5-year $3.3-million NIH grant to identify novel pharmaceuticals for combatting a host of diseases associated with altered levels of lipoproteins like LDL ("bad cholesterol").

11 Oct 2018

Molecular mechanisms behind therapeutic action of ancient herbal medicine discovered

Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for a therapeutic action of an ancient herbal medicine used across Africa to treat various illnesses, including epilepsy.

10 Oct 2018

Brown researchers uncover new clues about ALS progression

Brown University researchers have uncovered new clues about the progression of Amyotrophic Lateral Sclerosis (ALS), a surprisingly common disease that causes the death of motor neurons that control voluntary muscles such as those involved in walking, talking, chewing or breathing.

10 Oct 2018

VRK1 protein may enable cancer cells to colonize new areas of the body during metastasis

Sometimes negative results can point researchers in the right direction. In results published in PLOS ONE on September 4, 2018, scientists at the Medical University of South Carolina examined a protein called vaccinia-related kinase 1 that they hypothesized was important for metastasis. They found that, rather than causing cancer cells to migrate and invade, VRK1 over-expression had the opposite effect.

26 Sep 2018

New research suggests power of zebrafish as tool for cancer drug discovery

The lab of Leonard Zon, MD, at Boston Children's Hospital has long been interested in making blood stem cells in quantity for therapeutic purposes.

24 Sep 2018

UNC scientists reveal new approach to prevent obesity and diabetes

Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet.

19 Sep 2018

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Cells need for reactions on environmental changes and a balanced system of signaling cascades within the cell. Proteins outside of the cell, on the cellular surface, inside the cellular membrane, and within the cell orchestrate many fine-tuned signaling pathways, which result in adequate reactions on the environmental conditions or changes in the organism itself.

19 Sep 2018

Study gives new insights into how cells leverage GPCRs to control inflammation

G-protein-coupled receptors are everywhere in our bodies. They are embedded in our cell membranes, where they act as signal transducers, allowing cells to respond to their external environments.

19 Sep 2018

New project aims to increase patient willingness to take life-saving oral drugs

A new collaboration grant to scientists from Discovery BioMed, Inc. and the Monell Center will support development of next-generation screening technologies to enable identification of bitter taste blockers.

14 Sep 2018

Scientists gain better understanding of tumor initiation and metastasis in colon cancer patients

Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth.

11 Sep 2018

Researchers reveal effect of high amounts of cholesterol on specific ion channel in heart

Using a computer model, researchers from North Carolina State University and the University of Illinois at Chicago have revealed the effect of increased amounts of cholesterol on a specific ion channel involved in regulating potassium levels in the heart.

11 Sep 2018

Autism biomarker may aid early diagnoses

A newly discovered group of blood metabolites could act as a biomarker to accelerate the diagnosis of autism spectrum disorder.

6 Sep 2018

Researchers make discovery about yeast metabolism that could help drug developers

Researchers at the Francis Crick Institute have developed machine learning algorithms that can predict the metabolism of yeast based on its protein content.

6 Sep 2018

Research team to investigate how blood flow influences formation of plaque

Atherosclerosis-;the narrowing of arteries due to plaque buildup-;is the underlying reason for the majority of strokes and heart attacks. When atherosclerosis occurs in the arteries that carry blood to the heart muscle, it is called coronary artery disease, the No. 1 killer of Americans.

30 Aug 2018

Study could open new therapeutic avenues to attack herpesviruses

Human cytomegalovirus is a leading cause of birth defects and transplant failures. As it's evolved over time, this virus from the herpes family has found a way to bypass the body's defense mechanisms that usually guards against viral infections. Until now, scientists couldn't understand how it manages to do so.

28 Aug 2018

Protein modifications that indicate disease

Researchers from the University of Zurich can, for the first time, precisely characterize the protein modification ADP-ribosylation for all proteins in a tissue sample.

28 Aug 2018

Study reveals how gene variant affects chronic pain outcomes after trauma

The gene FKBP5 is a critical regulator of the stress response and affects how we respond to environmental stimuli. Previous studies have shown that certain variants of this gene play a role in the development of neuropsychiatric disorders such as posttraumatic stress disorder, depression, suicide risk, and aggressive behavior.

28 Aug 2018

Small Molecules News and Research

New findings could benefit patients with triple-negative breast cancer

Using pulsed electric fields in cancer therapy

How Does Amyloid Formation Impact Neurodegenerative Disease?

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Molecular mechanisms behind therapeutic action of ancient herbal medicine discovered

Brown researchers uncover new clues about ALS progression

VRK1 protein may enable cancer cells to colonize new areas of the body during metastasis

New research suggests power of zebrafish as tool for cancer drug discovery

UNC scientists reveal new approach to prevent obesity and diabetes

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Study gives new insights into how cells leverage GPCRs to control inflammation

New project aims to increase patient willingness to take life-saving oral drugs

Scientists gain better understanding of tumor initiation and metastasis in colon cancer patients

Researchers reveal effect of high amounts of cholesterol on specific ion channel in heart

Autism biomarker may aid early diagnoses

Researchers make discovery about yeast metabolism that could help drug developers

Research team to investigate how blood flow influences formation of plaque

Study could open new therapeutic avenues to attack herpesviruses

Protein modifications that indicate disease

Study reveals how gene variant affects chronic pain outcomes after trauma

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