Small Molecules News and Research

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Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

CENTOGENE today announced that Evotec AG and CENTOGENE AG entered into a global strategic collaboration agreement for joint drug discovery projects, developing compounds to treat rare genetic diseases.

27 Aug 2018

INRS professors develop innovative strategy to identify leishmanicidal molecules

Leishmania is a microorganism that enters the human body via a sandfly bite. Instead of fleeing the white blood cells deployed by the immune system to destroy it, the parasite allows itself to be swallowed up.

24 Aug 2018

Discovery could lead to new targeted treatment for people with lung cancer

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications.

22 Aug 2018

New tool fills gap in Small Molecules market

This news story covers the launch of SmallMolecules.com, an online tool for scientists looking to buy and compare molecules for their experiments.

From SmallMolecules.com 17 Aug 2018

Researchers discover new promising target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases.

15 Aug 2018

Scientists reveal role of 'junk DNA' in cancer dissemination

The more scientists explore so-called "junk" DNA, the less the label seems to fit.

14 Aug 2018

Researchers produce artificial placenta model that closely resembles natural organ

The placenta has an essential and highly complex task: it must ensure the exchange of important substances between the mother and her unborn child, whilst simultaneously blocking other substances from passing through.

14 Aug 2018

New strategy accelerates, automates process of prototype molecule optimization

The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology.

14 Aug 2018

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Nanoparticles show great promise as diagnostic tools and drug delivery agents. The tiny particles, which scientists can modify with drugs, dyes or targeting molecules, can travel in the circulation and squeeze through small spaces into cells and tissues.

9 Aug 2018

Scientists develop novel peptide drug that could potentially stop development of liver cancer

A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer.

2 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

New approach shows important role of microRNAs in papillomavirus life cycle

The discovery of microRNAs encoded by papillomaviruses supports the important role of these small molecules in persistent infection, according to a study published July 26 in the open-access journal PLOS Pathogens.

27 Jul 2018

New combination approach may help crush resistance to treatment in lung cancer patients

New-generation lung cancer drugs have been effective in a large number of patients, but within about a year, the patients tend to develop resistance to the therapy.

26 Jul 2018

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

New research gives insights into how the design of clinical trials can improve to address the "critically low" research pipeline and improve the chances of finding effective dementia therapies.

26 Jul 2018

PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides

PureTech Health plc, a clinical-stage biopharmaceutical company developing novel medicines focused on the Brain-Immune-Gut Axis, today announced that it has entered into a multiyear collaboration with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., to advance PureTech's milk-derived exosome platform technology for the oral administration of Roche's antisense oligonucleotide platform.

20 Jul 2018

Top AI companies join hands to discover novel drugs for DMD

Insilico Medicine a leader in artificial intelligence for drug discovery, biomarker development and aging research, announced a research collaboration agreement with A2A Pharmaceuticals, Inc. A2A is a biotechnology company headquartered in New York and focused on development of novel drugs for unmet needs in oncology, drug resistant bacterial infections, and other life threatening diseases.

20 Jul 2018

Scientists develop synthetic biology-inspired materials systems

Scientists from the University of Freiburg have developed materials systems that are composed of biological components and polymer materials and are capable of perceiving and processing information.

19 Jul 2018

Scientists identify hidden signals in RNAs that control protein synthesis

Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA-;A, U, C, and Gs-;form a blueprint for the protein-making machinery in cells. To make proteins, the machinery latches on RNA at one end and then scans along the RNA until it reaches an AUG string, which is the signal to start translating the genetic code into a protein.

17 Jul 2018

Research reveals why risks of complications in pregnancy vary based on baby's sex

The sex of a baby controls the level of small molecules known as metabolites in the pregnant mother's blood, which may explain why risks of some diseases in pregnancy vary depending whether the mother is carrying a boy or a girl, according to new research from the University of Cambridge.

12 Jul 2018

Small Molecules News and Research

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

INRS professors develop innovative strategy to identify leishmanicidal molecules

Discovery could lead to new targeted treatment for people with lung cancer

New tool fills gap in Small Molecules market

Researchers discover new promising target point for cancer and diabetes therapies

Scientists reveal role of 'junk DNA' in cancer dissemination

Researchers produce artificial placenta model that closely resembles natural organ

New strategy accelerates, automates process of prototype molecule optimization

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Scientists develop novel peptide drug that could potentially stop development of liver cancer

Researchers study how herpesviruses contribute to increased oral inflammation

New approach shows important role of microRNAs in papillomavirus life cycle

New combination approach may help crush resistance to treatment in lung cancer patients

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides

Top AI companies join hands to discover novel drugs for DMD

Scientists develop synthetic biology-inspired materials systems

Scientists identify hidden signals in RNAs that control protein synthesis

Research reveals why risks of complications in pregnancy vary based on baby's sex

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