Brain Metastases News and Research

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Targeted drug shows promising activity in kidney cancer patients with brain metastases

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

21 Oct 2021

Novel combination therapy identified for the brain metastases of breast cancer

A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy.

18 Oct 2021

MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases

In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain.

13 Oct 2021

Location of brain metastasis is not random, study indicates

Brain metastasis occurs when cancer in one part of the body spreads to the brain. The lifetime incidence of such metastatic brain tumors in cancer patients is between 20%-45%, research shows.

23 Sep 2021

Research could lead to new treatment option for breast cancer patients with brain metastases

Breast cancer patients whose cancer spreads to the brain may soon have new treatment options, thanks to research led by CU Cancer Center member Diana Cittelly, PhD.

21 Sep 2021

Combination of chemotherapy and immune checkpoint inhibitors shows promise in NSCLC patients with untreated brain metastases

Treatment with atezolizumab plus carboplatin and pemetrexed was safe and yielded promising brain progression-free survival in patients with nonsquamous non-small cell lung cancer with untreated and asymptomatic brain metastases.

12 Sep 2021

Simple blood test enables early detection of immunotherapy-triggered encephalitis

Immunotherapy is very effective for many cancers, but the treatment can also cause autoimmune side effects. Encephalitis is one of the most serious and difficult-to-diagnose side effects of immunotherapy.

2 Sep 2021

Deep learning model can classify intracranial tumors using a single 3D MRI scan

A team of researchers at Washington University School of Medicine have developed a deep learning model that is capable of classifying a brain tumor as one of six common types using a single 3D MRI scan, according to a study published in Radiology: Artificial Intelligence.

11 Aug 2021

New recommendations for diagnosis and treatment of brain metastases from solid tumors

Brain metastases are a common and dangerous complication in cancer patients. Under the leadership of experts from MedUni Vienna, two of the largest international oncology societies have published new clinical guidelines for the diagnosis and treatment of brain metastases from solid tumors.

9 Aug 2021

Morphle manufactures its 101st slide scanner for NIH’s NCI

Morphle Labs makes its ceremonial 101st scanner for NIH’s National Cancer Institute. It customized the scanner to fit the research needs of NCI.

From Morphle Digital Pathology 3 Aug 2021

Lung cancer detected by LDCT screening linked to lower brain metastases risk

Patients with primary lung cancer detected using low-dose computed tomography screening are at reduced risk of developing brain metastases after diagnosis, according to a study published in the Journal of Thoracic Oncology.

24 Jun 2021

Study may offer an unexpected pathway for targeted treatment of brain tumors

In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody.

15 Jun 2021

PET imaging can enable accurate diagnosis of recurring brain metastases

For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments.

5 May 2021

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

The April 2021 issue of JNCCN-;Journal of the National Comprehensive Cancer Network publishes new research from Memorial Sloan Kettering Cancer Center (MSK) and Gustave Roussy Institute, which suggests that baseline brain imaging should be considered in most patients with metastatic kidney cancer.

13 Apr 2021

Phase 3 clinical trial tests new treatment for brain metastases from small-cell lung cancer

A new phase 3 randomized clinical trial overseen by CU Cancer Center member Chad Rusthoven, MD, and Vinai Gondi, MD, from Northwestern University, is testing whether a new treatment approach could result in improved outcomes for patients with small cell lung cancer (SCLC) that has spread to the brain.

8 Apr 2021

Immune cells in cerebrospinal fluid could be novel biomarkers of response to immune-based therapies

Results from a study led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor, show that immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies.

8 Mar 2021

Brain Metastases News and Research

Targeted drug shows promising activity in kidney cancer patients with brain metastases

Novel combination therapy identified for the brain metastases of breast cancer

MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases

Location of brain metastasis is not random, study indicates

Research could lead to new treatment option for breast cancer patients with brain metastases

Combination of chemotherapy and immune checkpoint inhibitors shows promise in NSCLC patients with untreated brain metastases

Simple blood test enables early detection of immunotherapy-triggered encephalitis

Deep learning model can classify intracranial tumors using a single 3D MRI scan

New recommendations for diagnosis and treatment of brain metastases from solid tumors

Morphle manufactures its 101st slide scanner for NIH’s NCI

Lung cancer detected by LDCT screening linked to lower brain metastases risk

Study may offer an unexpected pathway for targeted treatment of brain tumors

PET imaging can enable accurate diagnosis of recurring brain metastases

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

Phase 3 clinical trial tests new treatment for brain metastases from small-cell lung cancer

Immune cells in cerebrospinal fluid could be novel biomarkers of response to immune-based therapies

RENACER: New national hospital network aims to advance research on brain metastases

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

New guidelines and standards for the treatment of brain tumor complications

Study shows how YTHDF3 plays a significant role in cancer metastasis

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